Musculoskeletal System Flashcards
Red fibers (slow-twitch)
High myoglobin content, aeorbic with many mitochondria
White fibers (fast-twitch)
Low myoglobin, less iron
Muscles that contract slowly but sustain activity
Red fibers
Muscles that contract rapidly but fatigue quickly
White fibers
Smooth muscle
Involuntary action, single nucleus, striations not visible
Skeletal muscle
Voluntary action, multinucleus, striated
Red fibers and white fibers are types of
Skeletal muscle
Myogenic activity
Muscle contracts without nervous system input
Myogenic activity is found in
Smooth and cardiac muscle
Cardiac muscle
Primary uninucleus but may contain two nuclei, involuntary, striated
Cardiac and smooth muscle are innervated by
Autonomic nervous system
Thick filaments are made of
Myosin
Thin filaments are made of
Actin, troponin, tropomyosin
Z-line
End of the sarcomere
M-line
Middle of myosin filaments
I-band
Thin filaments only
H-zone
Thick filaments only
A-band
All thick filaments
What band’s size remains constant during contraction
A-band
Sarcoplasmic reticulum
Modified endoplasmic reticulum with high [Ca2+]
Sarcolemma
Cell membrane of muscle cell, can propagate action potential
Muscle fiber vs myofibril
Muscle fiber consists of many myofibrils
Myofibril
Consists of many sarcomeres in series
T-tubules
Connected to sarcolemma, distributes action potential across muscle
Tetanus
Muscle contractions too frequent -> stronger, prolonged contraction of muscle
Osteoblast
Build bone
Osteoclast
Chew (resorb) bone
Hormone that promotes resorption of bone
PTH
Hormone that promotes bone formation
Calcitonin
Chondrocytes
Form cartilage
Spongy (cancellous bone)
Site of marrow production
Bones are attached to muscle by
Tendon
Bones are attached to each other at joints by
Ligament
Axial skeleton
Midline structures e.g. skull, vetebral column, ribcage, hyoid
Appendicular skeleton
Limbs, pelvis, pectoral girdle
Immovable joint
Bones that are fused together to form sutures
Movable joins
Strengthened by ligament, contain synovial capsule
Synovial fluid
Lubricates the joint
Lamellae
Circular rings of bone
Canaliculi
Channels that allow for exchange of nutrients and waste
Haversian and Volkmann’s canals
Contain blood vessels, nerves, and lymph vessels in bone
Lacunae
Osteocyte location
Epiphysis
End part of long bone
Metaphysis
Neck part where long bone flares
Diaphysis
Middle part of long bone
What provides the powerstroke
Release of ADP and Pi from myosin
Muscle contraction initiation
Release of acetylcholine from motor neuron -> activation of acetylcholine receptors in sarcolemma -> depolarization of sarcolemma -> T-tubules spread signal -> Ca2+ released from SR ->Ca2+ binds to troponin -> conformational shift in tropomyosin -> myosin binds to actin
ATP binding role in actin-myosin cross-bridge cycle
Allows myosin to detach from actin
Sliding filament model
Repetitive binding and sliding of myosin heads on actin allows thin filament to slide along thick filament, which leads to contraction