Muscle Tissue Flashcards

1
Q

What are skeletal muscles called?

A

myocytes or muscle fibers

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2
Q

What does groups of muscle fibers form?

A

fascicles

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3
Q

What are muscle fibers separated by?

A

endomysium

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4
Q

What are fascicles separated by?

A

perimysium

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5
Q

what surrounds the entire muscle?

A

epimysium

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6
Q

What is the cytoplasm of myofibers primarily occupied with?

A

myofibrils

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7
Q

Where is the nuclei located in skeletal muscle?

A

In the periphery

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8
Q

What are myofibrils composed of?

A

thin (actin) and thick (myosin) filaments

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9
Q

What is the basic functional unit of a myofibril?

A

sarcomere

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10
Q

What is the group of myofibrils surrounded by?

A

sarcolemma

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11
Q

What are the invaginations of the sarcolemma?

A

transverse(t)-tubules

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12
Q

What are the dilated ends of the sarcoplasmic reticulum that release Ca2+

A

terminal cisternae

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13
Q

anchor site for actin (thin) microfilaments?

A

Z-line

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14
Q

Anchor site for thick myosin filaments?

A

M-line

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15
Q

only contains actin thin filaments?

A

I-band

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16
Q

only contains myosin thick filaments?

A

H-zone

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17
Q

overlap of thick and thin filaments plus the H-zone?

A

A-band

18
Q

When a muscle cell contracts what occurs with the filaments?

A

the thin filaments slide past the thick filaments toward the center of the sarcomere bringing Z-lines closer together

19
Q

What are the regulatory proteins found in thin filaments?

A

tropomyosin and troponin

20
Q

Runs in groove formed by F-actin strands

A

tropmyosin

21
Q

what does tropomyosin bind to?

A

to the troponin complex

22
Q

Troponin is a complex composed of what?

A

3 proteins, troponin I, troponin C, and troponin T

23
Q

What is the role of troponin T?

A

it binds tropomyosin to the complex

24
Q

What is the role of troponin I?

A

it inhibits the binding of myosin to actin

25
Q

what is the role of troponin C?

A

it binds Ca2+ and is only found in striated muscle

26
Q

What is the regulatory protein that permits cross-bridge formation when it binds Ca2+

A

troponin

27
Q

What carries the depolarization from the sarcolemmal membrane to the cell interior

A

T-tubules

28
Q

What is the site of Ca2+ storage and release for excitation-contraction coupling?

A

sarcoplasmic reticulum

29
Q

What does depolarization of of the T tubules cause?

A

a conformational change in its dihydropyridine receptor (DHPR)

30
Q

what does a conformation change in the DHPR cause?

A

opens Ca2+ release channels in the nearby sarcoplasmic reticulum

31
Q

What happens when Ca2+ binds to troponin C on the thin filaments?

A

it causes a conformational change in troponin that moves tropomyosin out of the way

32
Q

When does the cross-bridge cycle begin?

A

once calcium binds to troponin c and moves tropomyosin out of the way

33
Q

What happens when ATP binds to myosin?

A

it produces a conformational change in myosin that causes myosin to be released from actin

34
Q

What causes myosin to be displaced toward the plus end of actin?

A

hydrolysis of ATP to ADP and inorganic phosphate

35
Q

sites of special cell adhesions and low electrical resistance

A

intercalated discs

36
Q

ribbon- like adhesions found at the ends of terminal sarcomeres and anchored to actin filaments

A

fascia adherens

37
Q

spot-like adhesions between cells anchored to intermediate filaments of the cell

A

desmosome

38
Q

small channel-like connections between cells allowing excitation/contraction wave to pass from one cell to the next connected cell

A

gap junctions

39
Q

How does cardiac muscle contract?

A

rhythmically without innervation

40
Q

What is the most predominant junction in cardiac muscle?

A

fascia adherens

41
Q

Which junction transmits contractile forces between cells in cardiac muscle?

A

fascia adherens

42
Q

What are dense bodies of smooth muscle comprised of?

A

desmin and vimentin intermediate filaments