Multiple endocrine neoplasia Flashcards
define multiple endocrine neoplasia?
an autosomal dominant condition characterised by a predilection to develop tumours of endocrine glands.
what is the inheritance pattern of MEN?
• Autosomal dominant inheritance
which cancers are common with MEN type1?
- adrenal and thyroid 3 Ps - parathyroid - pituitary - pancreas
which cancers are common with MEN type 2a?
2Ps
Parathyroid (60%)
Phaeochromocytoma
which cancers are common with MEN type 2b?
1P
Phaeochromocytoma
Marfanoid body habitus
Neuromas
what is a typical presentation of MEN type 1 ?
o Peptic ulceration
o Galactorrhoea
o Hypercalcaemia
which gene is associated with MEN type 1?
MEN1 gene
which gene is associated with MEN type II?
RET oncogene
how to investigate for Phaeochromocytoma ?
24 hr urine metanephrines
how to investigate for Medullary thyroid cancer ?
elevated calcitonin concentration
how to investigate for parathyroid tumours?
simultaneously elevated Ca2+ and PTH