Multiple endocrine neoplasia Flashcards

1
Q

define multiple endocrine neoplasia?

A

an autosomal dominant condition characterised by a predilection to develop tumours of endocrine glands.

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2
Q

what is the inheritance pattern of MEN?

A

• Autosomal dominant inheritance

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3
Q

which cancers are common with MEN type1?

A
- adrenal and thyroid 
3 Ps 
- parathyroid 
- pituitary 
- pancreas
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4
Q

which cancers are common with MEN type 2a?

A

2Ps
Parathyroid (60%)
Phaeochromocytoma

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5
Q

which cancers are common with MEN type 2b?

A

1P
Phaeochromocytoma
Marfanoid body habitus
Neuromas

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6
Q

what is a typical presentation of MEN type 1 ?

A

o Peptic ulceration
o Galactorrhoea
o Hypercalcaemia

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7
Q

which gene is associated with MEN type 1?

A

MEN1 gene

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8
Q

which gene is associated with MEN type II?

A

RET oncogene

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9
Q

how to investigate for Phaeochromocytoma ?

A

24 hr urine metanephrines

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10
Q

how to investigate for Medullary thyroid cancer ?

A

elevated calcitonin concentration

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11
Q

how to investigate for parathyroid tumours?

A

simultaneously elevated Ca2+ and PTH

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