MSK Flashcards
polymyalgia rheumatica vs polymyositis
PR - stiff & pain, raised CPR
P - weakness, raised CK
risk of dermomyositis
cancer
what causes SLE
increased apoptosis -> defective clearance -> immune complex formation -> compliment activation
specific vs sensitive SLE antibodies
anti - DsDNA - specific
ANA - sensitive
antibody in mixed connective tissue disease
anti - RNP
treatment of raunads
Ca blockers
phosphodiesterase enzyme inhibitors
which arteries are effected in tayaski vasculitis?
the ones coming off the aortic arch
small vessel vasculitis
ANCA +
no gramulomas
microscopic polyangitis (pANCA)
ANCA - small vessel vasculitis’
IgA + - henoch purpura
serum cryoglobulin + - cryoglobineamia
treatment of AVN
no collapse = drilling decompression
collapse - joint replacement
what is osteochondritis (+ dissecans)
inflammation of bone and cartilage (bone and cartilage seperate)
osteochondroma vs enchroma
(both benign)
o - boney growth with cartilaginous cap
e - intramedullary metaphyseal cartilage tumour
giant cell tumour
benign
‘soap bubble’
painful
‘shepards crook’
fibrous dysplasia in femour
osteosarcoma vs chondrosarcoma
(both malignant)
o - worse @ night, kids, knee
c - older, pelvis
‘onion skin’ bone tumour
ewings - malignant
investigation into multiple myeloma
bone protein assay
osteoid osteoma
immature bone surrounded by slclerotic halo
releases prostiglandins
treat with NSAIDs