heam

Question 1

hypersegmented neutrophils

Answer 1

megaloblastic anaemia

Question 2

treatment of thalassaemias

Answer 2

lifelong transfusions

Question 3

which bleeding disorders effect which clotting factors?

Answer 3

Heamophilia A - VIII
“ B - IX
von willibran - VII
vit K deficiency - II, VII, IX, X

Question 4

aPTT vs PT

Answer 4

aPTT - intrinsic clotting (heparin)
PT - extrinsic (warfarin)

Question 5

tear drop poikilocytes

Answer 5

myelofibrosis

Question 6

smudge cells

Answer 6

chronic lymphoblastic leukaemia

Question 7

richets transformation

Answer 7

CLL -> diffuse large B-cell lymphoma

Question 8

auer rods

Answer 8

acute myeloid leukaemia

Question 9

phildelphia chromosome

Answer 9

chronic myeloid leukeumia

Question 10

leukaemia in kids

Answer 10

acute lymphoblastic

Question 11

howell jolly bodies

Answer 11

hyposplenism (normally nuclear remnants removed by spleen)

Question 12

ring sideroblasts

Answer 12

myelodysplastic syndrome

Question 13

bronze skin

Answer 13

hereditary haemochromatosis??

Question 14

FBC thalassaemia

Answer 14

normal except decreased TIBC

Question 15

FBC anaemia of chronic disease

Answer 15

everything decreased except serum ferritin

Question 16

symptoms of lead poisoning

Answer 16

decreased transferrin
neurological symptoms

microcytic anaemia (TAILS)

Question 17

treatment of hyposplenism caused by sickle

Answer 17

proph penicillin

Question 18

treatment of sideroblastic anaemia

Answer 18

pyridoxine - B6

Question 19

pathology of ITP

Answer 19

antibodies against platelets

Question 20

mechanism of clopi

Answer 20

ADP antagonist

Question 21

complications of polycythemia vera

Answer 21

AML
myelofibrosis

Question 22

flava beans -> sick

Answer 22

G6PD deficiency

Question 23

what is factor V leidens mutation

Answer 23

activated protein C resistance

Question 24

investigation into multiple myeloma

Answer 24

whole body MRI

Question 25

INR calculation

Answer 25

(patients PTT/ normal PTT)ISI

Question 26

treatment of CML

Answer 26

imatinib

Question 27

what does CLL transform into

Answer 27

non-hodgkins

Question 28

treatment of ITP

Answer 28

oral steroids

Question 29

investigation into sickle

Answer 29

heamoglobin electrophoresis

Question 30

rate of RBC transfusion

Answer 30

not urgent - 2hrs

urgent - STAT

Question 31

how long before surgery should you stop warfarin?

Answer 31

5 days

Question 32

tumour lysis syndrome

Answer 32

increased K, phosphate & reduced Ca

treat with allopurinol & IV fluids

Question 33

treatment of hypercalceamia

Answer 33

saline

Question 34

plummer-vinson disease

Answer 34

dysphagia (oesophageal webs)
glossitits
iron deficient anaemia

Question 35

normocytic aneamia + low iron

Answer 35

anaemia of chronic disease

Question 36

pencil poikilocytes

Answer 36

iron deficient anaemia

Question 37

schistocytes

Answer 37

intravascular heamolysis - HUS

Question 38

spherocytes

Answer 38

autoimmune heamolytic anaemia

Question 39

basophilic stippling

Answer 39

thalassaemia
lead poisoning

Question 40

heinz bodies

Answer 40

g6pd deficiency
alpha thalassaemia

Question 41

Reed sternberg cells

Answer 41

hodgkins lymphoma

Question 42

burkitts lymphoma translocation

Answer 42

t(8;14)

Question 43

Waldenstorms macroglobinaemia

Answer 43

IgM paraprotein

Question 44

target cells

Answer 44

hyposplenism
Iron deficiency
sickle cell
thalassaemia

Question 45

heparin induced thrombocytopaemia

Answer 45

antibodies against heparin
hypercoaguable
5-10 days after treatment

Question 46

what causes a minor allergic reaction

Answer 46

forgein plasma proteins

Question 47

what causes bacterial infection in transfusion

Answer 47

platelets

Question 48

intermittent fever + travel

Answer 48

malaria

Question 49

treatment of non hodgkins lymphoma

Answer 49

rituximab
prednisilone

Question 50

shic