MSK Flashcards
What are kinins?
Polypeptides which work to increase migration of WBCs during the inflammatory process
- Attract phagocytes
- Promote vasodilation
- Increase permeability of blood vessels
Which structure is affected in a pulled elbow?
Annular ligament
What is the most common form of JIA?
Persistent oligoarthritis
Which HLA is associated with Bechets disease?
HLA-B5
Which HLA is associated with reactive arthritis?
HLA-B27
Which antibody in SLE is associated most with severe systemic involvement?
anti-dsDNA
Which antibody is typically associated with microscopic polyangiitis?
p-ANCA
What are the early X-rays signs of ankylosing spondylitis?
Blurring of the upper and/or lower vertebral rims at the thoracolumbar junction
What are the signs associated with polyarteritis nodosa
Chronic renal failure
Hypertension
Thrombosis
Infarction
Aneurysms
Necrotising arteritis
What does polyarteritis often show on renal biopsy?
Necrotising proliferative GN with crescentic formation
What is the test most likely to lead to a diagnosis of SMA?
Array CGH
How is SMA inherited?
AR
Which gene is implicated in SMA?
SMN1
What is Trethowan’s sign?
Klein line (line drawn across superior edge of the neck of the femur) does not transect the lateral capital epiphysis - indicating SUFE
