Dermatology Flashcards
Which organism most often causes bullous impetigo?
Staph aureus
How is bullous impetigo treated?
Systemic abx - flucloxacillin
What are the ocular signs of albinism?
Failure to develop a fixation reflex
Pendular nystagmus
Photophobia causing frowning
Is the AD or AR form of epidermolysis bullosa more severe?
AR form
When does infantile seborrhoeic dermatitis present?
First 3 months life
How is mild seborrhoeic dermatitis treated?
Emollients
How is more persistent or severe seborrhoeic dermatitis treated?
Sulphur and salicylic acid ointment for scaling
Mild corticosteroid +/- antibacterial and antifungal agents
What 2 commonest pathogenic organisms can cause secondary infection in atopic eczema?
Staph aureus
HSV
What percentage of children with atopic eczema has settled by age 16?
75%
What percentage of children with atopic eczema has settled by age 12?
50%
How are viral warts on hands or feet typically treated?
Salicyclic acid and lactic acid paint or glutaldehyde 10% lotion
Cryotherapy in older children
What does the typical lesion in molluscum contageosum look like?
small, skin-coloured pearly papules with central umbilication
How does tinea capitis usually present?
Scaling and patchy alopecia with broken hairs
Woods light may reveal bright green/yellow fluorescence
Where do scabies lesions typically occur in older children?
Finger and toe webs, flexor aspects of wrists, belt line, around nipples, penis and buttocks
Where do scabies lesions typically occur in younger children?
Palms and soles
What is the treatment of scabies?
Permethrin cream 5% below the neck, left on for 8-12hours then washed off
Face and scalp included in infants
OR
Benzyl benzoate 25% left on for 12hours then washed off#
OR
Malathion lotion 0.5% left on for 12hours
How is head lice treated?
Dimeticone 4% or malathion 0.5% applied into scalp and left overnight, then hair shampooed following morning
Repeated 1 week later
Wet combing every 2-3days for 2 weeks
What does guttate psoriasis appear as?
raindrop like lesions which are scaly and on trunk and upper limbs
In which condition does a ‘Christmas tree’ rash occur?
Pityriasis Rosea
What is pediculosis capitis?
Headlice
At what age does the embryonic epidermis begin to stratify?
8 weeks
In which condition does a herald patch occur?
Pityriasis Rosea
Which condition has exclamation mark hairs?
Alopecia
What type of collagen is affected in Ehlers-Danlos syndrome?
Type V collagen
Which gene mutations are associated with classical Ehlers-Danlos syndrome?
COL5A1 and COL5A2
What is type I collagen used for?
Bone construction
What does type 2 collagen do?
Main component of cartiledge
What condition is associated with defects in collagen I?
Osteogenesis imperfecta
What conditions are associated with defects in type II collagen?
Achondroplasia and Stickler syndrome
What conditions are associated with defects in type III collagen?
Vascular type EDS
What does type IV collagen normally do?
Forms basal lamina
What conditions are associated with defects in type IV collagen?
Alport syndrome
Goodpasture syndrome
Keloid scars are associated with and excess of what type of cell?
Fibroblasts
At what age does keratinisation occur in the fetus?
19 weeks
How does a fixed drug eruption typically present?
Well demarcated, round or oval, hyperpigmented macules or plaques that recur around the same site upon re-exposure to a drug
What is the mechanism of action of cyproterone acetate?
Inhibition of 17-alpha-hydroxylase thus reducing androgen production
How does Gianotti-Crosti syndrome typically present?
Characteristic pattern of rash on thighs, buttocks, upper arm and cheeks following a URTI.
Rash typically erythematous and papular in nature
What is the typical rash associated with neonatal SLE?
Erythematous, papulosquamous rash with fine scales and central clearing
What are the typical features of Bloom syndrome?
Growth retardation
Photosensitivity
Pigment abnormalities
Telangiectasia
How is Bloom syndrome inherited?
AR pattern
Which cancers does Bloom syndrome predispose to?
Leukaemia and Lymphoma
What does tumour-supression gene TSC1 encode?
Hamartin
What infections can lead to SJS most commonly?
HSV
Mycoplasma pneumoniae
Which layer of the skin does vitiligo affect?
Epidermis
Which enzyme is affected in Sjogren-Larsson syndrome?
Fatty aldehyde dehydrogenase
Which drugs are known to predispose to SJS?
Penicillins
Barbiturates
Phenytoin
OCP
Which immunoglobulin is most typically seen on immunofluorescence in bullous pemphigoid?
IgG4