MSK Flashcards

1
Q

What haem condition can predispose to pseudogout

A

hemochromatosis

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2
Q

allopurinol MOA

A

xanthine oxidase inhibitor

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3
Q

Main SE of colchicine

A

diarrhoea

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4
Q

treatment of septic arthritis

A

flucloxacillin/clindamycin for staph aureus 4-6 weeks
Cipro if gonorrhoea

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5
Q

Rheumatoid arthritis monitoring

A

DAS28 + CRP

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6
Q

most common extra-articular manifestation of RA

A

keratoconjunctivitis sicca

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7
Q

how to differentiate reactive and septic

A

in reactive, organism cannot be recovered from joint

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8
Q

specific eye conditions associated with reactive arthritis

A

conjunctivitis and anterior uveitis

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9
Q

psoriasis management

A

First line
1. potent corticosteroid + vitamin d analogue

Second line
1. Phototherapy (can cause SCC)
2. Oral methotrexate

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10
Q

Long term management of antiphospholipid syndrome

A

low dose aspirin (warfarin lifelong if had thrombotic event)

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11
Q

What can cause polymyositis and dermatomyositis

A

paraneoplastic syndrome
viral infection e.g. cosackie virus/HIV

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12
Q

Critical test for myositis

A

CK

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13
Q

What tests are done for ACL

A

Anterior drawer tests (ACl moves)
Lachmans (ACL moves)

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14
Q

Bakers cyst important differential

A

DVT

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15
Q

serious complication of baker cyst

A

compartment syndrome

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16
Q

Why do you not use steroid injections in foot

A

rupture of plantar fascia or fat pad atrophy

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17
Q

What is bechets disease

A

oral ulcers
genital ulcers
anterior uveitis

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18
Q

Why do you get AKI with compartment syndrome

A

accumulation fo myoglobin in kidneys

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19
Q

Which clinical sign points towards compartment syndrome

A

pain on passive stretch

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20
Q

How does ostechondritis dissicens present

A

pain after exercise
intermittent locking and swelling of joint

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21
Q

most common cause of death is systemic sclerosis

A

respiratory involvement: interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH)

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22
Q

Antibodies associated with systemic sclerosis

A

CREST: anti-centromere
Diffuse: Anti-SCL70

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23
Q

CREST syndrome

A

Calcinosis
Raynauds
oesophageal motility
sclerodactyly
telangtascia

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24
Q

What antibiotic should you not co-prescribe with methotrexate

A

trimethoprim
severe bone marrow suppression and pancocytopenia

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25
Q

What medication can cause drug induced lupus

A

isonazid

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26
Q

diagnostic investigation for osteomyelitis

A

MRI

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27
Q

RA x-ray findings

A

loss of joint space
juxta-articular osteoporosis
soft-tissue swelling
periarticular erosions
subluxation

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28
Q

ottawa ankle rules

A

Inability to walk four steps
Bony tenderness at the medial malleolar zone (tip of medial malleolus to lower 6cm of posterior border of tibia)
Bony tenderness at the lateral malleolar zone (tip of lateral malleolus to lower 6cm of posterior border of fibula).

29
Q

Pain on the radial side of the wrist/tenderness over the radial styloid process ?

A

De Quervain’s tenosynovitis

30
Q

bisphosphonate alternative?

A

denosumab if egfr <30

31
Q

pre-op imaging in someone with RA

A

Anteroposterior and lateral cervical spine radiographs
- Atlantoaxial subluxation can lead to cervical cord compression.

32
Q

L3 nerve root

A

Sensory loss over anterior thigh
Weak hip flexion, knee extension and hip adduction
Reduced knee reflex
Positive femoral stretch test

33
Q

L4 nerve root

A

Sensory loss anterior aspect of knee and medial malleolus
Weak knee extension and hip adduction
Reduced knee reflex
Positive femoral stretch test

34
Q

L5 nerve root

A

Sensory loss dorsum of foot
Weakness in foot and big toe dorsiflexion
Reflexes intact
Positive sciatic nerve stretch test

35
Q

S1 nerve root

A

Sensory loss posterolateral aspect of leg and lateral aspect of foot
Weakness in plantar flexion of foot
Reduced ankle reflex
Positive sciatic nerve stretch test

36
Q

who is more likely to get osteonecrosis of the jaw with bisphosphonates

A

cancer patients

37
Q

extra articular signs of psoriatic arthritis

A

tenosynovitis and soft tissue inflammation resulting in:
- enthesitis: inflammation at the site of tendon and ligament insertion e.g. Achilles tendonitis, plantar fascitis
- tenosynovitis: typically of the flexor tendons of the hands
- dactylitis: diffuse swelling of a finger or toe
- nail changes
pitting
onycholysis

38
Q

x-ray findings with psoriatic arthritis

A

‘Plantar spur’ and ‘pencil and cup’

39
Q

how to differentiate psoas abscess and osteomyelitis

A

psoas has pain on hip extension

40
Q

most common cause of psoas abscess

A

Staphylococcus aureus: most common
crohns

41
Q

what should be checked before starting azathioprine/mercaptopurine

A

thiopurine methyltransferase deficiency (TPMT)

42
Q

colles fracture complications

A
  • median nerve injury
  • compartment syndrome
  • vascular compromise
  • osteoarthritis
  • complex regional pain syndrome
43
Q

colles fracture

A

dorsally displaced distal radius -> dinner fork deformity

44
Q

4 features of scaphoid fracture

A
  1. pain on longitudinal compression of thumb
  2. tenderness in anatomical snuffbox
  3. pain along the radial aspect of the wrist, at the base of the thumb
  4. loss of pincer grip strength
45
Q

ulnar paradox

A

proximal lesions of the ulnar nerve produce a less prominent deformity than distal lesions

46
Q

ulnar nerve damage features

A
  • weak finger abduction and adduction with reduced sensation over the ulnar border of his hand
  • clawing of 4th and 5th digits
47
Q

CK in PMR

A

normal but raised ESR

48
Q

osteomyelitis cause

A

Staph. aureus is the most common cause except in patients with sickle-cell anaemia where Salmonella species predominate

49
Q

what drug reduces risk of renal crisis in systemic sclerosis

A

ace-inhibitors

50
Q

AS x ray

A

subchondral erosions, sclerosis
and squaring of lumbar vertebrae

51
Q

routine monitoring with methotrexate

A

LFTs

52
Q

methotrexate toxicity treatment

A

Folinic acid

53
Q

complications of pagets

A

deafness (cranial nerve entrapment)
bone sarcoma (1% if affected for > 10 years)
fractures
skull thickening
high-output cardiac failure

54
Q

adverse effects of methotrexate

A

mucositis
myelosuppression
pneumonitis
pulmonary fibrosis
liver fibrosis

55
Q

most common type of intracapsular hip fracture

A

subcapital fracture

56
Q

what nerve meralgia paresthetica

A

lateral cutaneous nerve of thigh compression

57
Q

psoas abscess investigation

A

CT abdomen

58
Q

features of de quervain’s tenosynovitis

A
  • pain on the radial side of the wrist
  • tenderness over the radial styloid process
  • abduction of the thumb against resistance is painful
  • Finkelstein’s test: the examiner pulls the thumb of the patient in ulnar deviation and longitudinal traction. In a patient with tenosynovitis this action causes pain over the radial styloid process and along the length of extensor pollisis brevis and abductor pollicis longus
59
Q

most common cause of discitis

A

staph aureus

60
Q

How to differentiate bullous pemphigoid and pemphigoid vulgaris

A

no mucosal involvement (in exams at least*): bullous pemphigoid
mucosal involvement: pemphigus vulgaris

61
Q

what is mcmurrys test for

A

meniscal tears
ACL: drawer test

62
Q

posterior hip dislocation nerve

A

sciatic (leads to foot drop as common peroneal is a branch)

63
Q

nerve conduction in carpal tunnel

A

Action potential prolongation in both sensory and motor axons

64
Q

myeloma biochemical features

A

high calcium, normal/high phosphate and normal alkaline phosphate

65
Q

what should never be prescribed with allopurinol

A

azathioprine -> bone marrow suppression

66
Q

psoriatic arthritis complications

A

CVD

67
Q

charcot joint

A

diabetes and described as gammy

68
Q

what antibiotic increases risk of achilles tendon rupture

A

cipro