MRSA Drugs

Question 1

Vancomycin and lypoglycoprotiens both have a MOA that _______ _______ ______ synthesis

Answer 1

inhibits cell wall

Question 2

Vancomycin is bacterio____(except enteroccous which is concentration dependent) and is second line tx for _____. A common ADR is ____ _____ syndrome and it is pregnancy category _____

Answer 2

cidal, c. diff, Red Man’s, B

Question 3

Vancomycin is a renal drug so monitoring is really important as well as dosing. This means that weight (should/should not) be considered for dosing? Dosing should be effective when above ____ but does not need to reach _____

Answer 3

should, MIC, CMax

Question 4

Describe Red Many’s syndrome

Answer 4

Flushing of chest/ face, hypotension, pruitits

Question 5

Oxazolidinones include ______ and ____ which are synthetic drugs that inhibits protein synthesis by binding _____ _______ ______. They are also reversible, non selective inhibitors of _____ _____ which allows ______ to build up in the system

Answer 5

linezolid, tedizolid, 50s ribosomal subunit. monoamine oxidase, ccatecholamines

Question 6

Linezolid is poor against G- and anaerobes but great for drug resistant bacteria including (4)

Answer 6

MRSA, Vanco-resistant enterococcus, Vanco Resistant Staph Aureus, PCN resistant strep pneumo

Question 7

Linezolid is indicated for treatment of (3) and second line off label use for _____

Answer 7

Pneumonia (HAP/CAP), SSTI and vanco resistant enterococci…. Osteomyelitis

Question 8

What should you monitor for a pt on linezolid?

Answer 8

Tyramine consumption (no red wine, cheeses or processed meats

Question 9

Tedizolid is indicated for 3 bacteria what are they. It is also indicated for SSTI’s caused by

Answer 9

S. Aureus, Strep, enterococci….Staph aureus including MRSA

Question 10

Both oxazolidinones are associated with deficiencies in blood components as ADRs. Linezolid has ______ and tedizolid has ____ both also have headaches as ADRs as well

Answer 10

pancytopenia (deficient in RBC, WBC and platelets), neutropenia (low neutrophils). Headaches

Question 11

Lypoglycopeptides interferes with ____ ____ of _____ in bacterial cell walls and are indicated for use of ________

Answer 11

cross linking of peptidoglycan, ABSSI (Acute bacterial skin and skin structure infections = lesions >/= 75 cm)

Question 12

If you gave a patient oritavancin for her ABSSI, what two drugs should you not give her 24 hours and 48 hrs after doing so? Why?

Answer 12

Warfarin is an interaction–> prolongs INR 24 hrs after dose and Heparin, it will prolong PTT (partial thromboplastin time)

Question 13

What are the ADRs of lypoglycopeptides

Answer 13

Hypersensitivity, CDAD, N/V/D, Headache

Question 14

Mucipiron inhibits ____ ______ ____ and is indicated for ____ and _____

Answer 14

bacterial protein synthesis, impeteigo, intranasal MRSA conolization

Question 15

Quinupristin inhibits the _____ phase of protein synthesis while Dalfopristin inhibits the ______. they are used for (4 bacteria) and life threatening _____ and complicated _____

Answer 15

late , early
MRSA, VRE, resistant S. pneumo, S. epi
VRE, SSTI

Question 16

Common ADRs to Quinupristin-Dalfopristin include

Answer 16

myalgia/arthralgias, hyperbilirubinemia and CDAD (also a P40 inhibitor)

Question 17

Whats the name of the new C. Diff med? What are its ADRs?

Answer 17

Bezlotoxumab, increased mortality in HF pts, nausea, headache, infusion reactions

Question 18

Whats the last resort antibiotic? Why don’t we use it even though it covers pseudomonas?

Answer 18

Colistin, renal toxicity