Aminoglycosides

Question 1

Name 5 aminoglycosides

Answer 1

gentamicin, tobramicin, amikacin, streptomycin, neomycin

Question 2

Aminoglycocides are bacterio___ and bind to ribosomal subunit ____

Answer 2

cidal, 30s

Question 3

Aminoglycosides are indicated for _____

Answer 3

severe G- infections including : pyelonephritis, severe UTI, HAP with MDR organisms with combination b-lactam, meningitis, peritonitis, bacterial endocarditis, sepsis with pseudomonas and ophthalmic/otic infections

Question 4

Aminoglycosides cause ______, ______ and ______ as ADR’s

Answer 4

Vestibular, auditory (ototoxicity) and nephrotoxicity

Question 5

Vertigo and ataxia are more common with _____

Answer 5

strepmycin and gentamicin

Question 6

______ has the greatest risk for nephrotoxicity while _____ has the least risk

Answer 6

neomycin, streptomycin

Question 7

T/F: weight base dosing is not important in aminoglycosides

Answer 7

F, need weight base dosing due to the fact they do not distribute well into adipose tissue

Question 8

What is the difference between traditional and extended dosing for aminoglycosides?

Answer 8

Traditional: 2-3 doses/ day measuring peak and trough levels
Extended: one higher dose daily monitor by a single random level at 6-14 hrs

Question 9

What type of pts require a higher dose of aminoglycosides?

Answer 9

cystic fibrosis and burn pts