Fluoroquinolone

Question 1

Fluoroquinolones are bacterio____ and inhibit DNA synthesis by inhibiting DNA ____ and ______ which causes rapid cell death

Answer 1

cidal, gyrase, topsimerase IV

Question 2

FQ’s work best in:

Answer 2

Kidney, lung, bile, stool, neutrophil/macrophages and prostate tissue

Question 3

The two FQ’s used for respiratory dzs are

Answer 3

levofloxacin and moxifloxacin

Question 4

FQ’s are not recommended for pts under ____ y/o due to risk of bone and cartilage injury. It is also a renal drug that causes _____ & _____

Answer 4

16, C. Diff, long Q-T

Question 5

Infectious diseases society of America suggests FQ’s are first line for _____ and ______

Answer 5

inpatient CAP, outpatient CAP in pts with comorbidities

Question 6

ISDA also sats that in a pt with pseudomonas pneumonia we would want to give our pt a ____ + _____ + ____

Answer 6

FQ, b-lactam, aminoglycoside

Question 7

ISDA states FQ are also first line for ____ (not pneumonia related) and second line _____

Answer 7

Pyelonephritis, acute uncomplicated UTI

Question 8

Ciprofloxacin is second line for ____.

Answer 8

TB

Question 9

Ofloxacin/levofloxacin and Moxifloxacin are both strongly indicated for _____ but Moxifloxacin is better for ____ pathogens

Answer 9

chronic bronchitis, enteric

Question 10

Both ______ and ____ cover pseudomonas in the FQ class

Answer 10

Cirpofloxacin, levofloxacin

Question 11

Gatifloxacin is indicated for_____

Answer 11

bacterial conjunctivitis in pts >1 y/o