Amoebiasis Flashcards
What is leishmaniasis?
a parasitic disease in the tropics/subtropics and South France found in sand flies
What medication can be used to treat leishmaniasis?
Miltefosine
Miltefosine (can/cannot) be used in pregnant patients
cannot
ADRs of Miltefosine include
NVD, HA, abd pain, elevated LFTs, decreased appetite
Amoebiasis medications include
Paromomycin, Tinidazole, Metronidazole
Amoebiasis medications are used to treat sx such as ___, commonly associated with places of poor sanitation such as ___
bloody diarrhea; Africa, Asia, Latin America, and US overseas travelers
Metronidazole is considered 1st line treatment for ___, but can also be taken for ___, ___, and ___.
C Diff; rosacea; bacterial vaginosis; trichomonas
Metronidazole is a (bactericidal/bacteristatic) prodrug
bactericidal
Metronidazole crossed the BBB and is considered a pregnancy category ___ drug
B
Since Metronidazole crosses the BBB, patients should be warned that they may encounter CNS effects while taking this medication, such as …
sz, encephalopathy, neuropathy, aseptic meningitis
ADRs of Metronidazole can include
black hairy tongue, candidiasis, dysgeusia, HA, NVD, abd pain
Metronidazole can interact with ___ to cause hepatotoxicity and cardiotoxicity, and with ___ which can cause psychotic reactions.
Alcohol; disulfam
Tinidazole is a lot like what other medication?
Flagyl
Tinidazole is indicated for ___, ___, ___, and ___. It can be used off label for ___, but is not first line.
trichomoniasis, bacterial vaginosis, amebiasis, giardiasis; H. pylori eradication
Potential ADRs of Tinidazole include
Neuropathy, sz, metallic taste, weakness and fatigue
