Antihelminths Flashcards
What medication is considered THE worm drug?
Mebendazole
Mebendazole works by inhibiting ___ formation by preventing uptake of glucose necessary for drastic metabolism
worm tubule
Mebendazole is indicated for small worms, such as ___, ___, ___, and ___. It may be useful against ___.
hookworms, pinworms, roundworms, and whipworms; tapeworms
Mebendazole is a pregnancy category ___ medication
C
Taking mebendazole may cause ADRs such as
ABD pain, diarrhea, rash, urticaria
While taking Mebendazole, a patient’s ___ function and ___ should be monitored
liver function; CBC
Mebendazole absorption is improved when taking with ___ foods
fatty
Albendazole is indicated for big worms, such as ___. It can be used off label for ___.
tapeworms; hookworms
Albendazole is a pregnancy category ___ medication
C
Potential adverse drug reactions of Albendazole include
Abd pain, NV, HA, dizziness, vertigo, elevated LFTs
Before prescribing a patient Albendazole, we must perform an exam of their ___, to r/o worm involvement
eye (ew!)
Death of parasites (secondary to Albendazole–or not) in the ___ may cause infalmmatory reactions, and so we should consider pretreatment with ___ and ___.
brain; steroids and anticonvulsants
Absorption of Albendazole is not great systematically, but is improved with which type of food?
fatty
Which antehelminth medication is metabolized in the liver as a CYP 3A4 P450 medication?
Pyraziquantel
Pyraziquantel is a pregnancy category ___ medication
B
