Tetracyclines

Question 1

Tetracyclines as a class have a bacterio____ effect

Answer 1

static

Question 2

Name some bacteria tetracylines as a class cover (11)

Answer 2

N. gonorrhea, H. ducreyi, H. flu, Yersinia pestis, francisella tularensis, Vibrio cholera, Baronella bacilliformis, Brucella species, chlamydia, mycoplasma, rickettsiae

Question 3

Tetracyclines as a class are pregnancy category ___. Knowing this, is it ok to still use doxycycline to treat RMSF in pregnant woman and in children?

Answer 3

D. Yes but only for RMSF

Question 4

One serious adverse effect of tetracyclines as a class is the Jarisch Herxheimer reaction. What is this?

Answer 4

Reaction that is often seen after tx for syphillis with PNC but can be seen with lyme disease, leptospirosis, brucellosis and relapsing fever with tetracyclines that includes mild fever, chills, headache, malaise which can progress to a seizure. It occurs due to inflammation after a large number of organisms die

Question 5

Doxycycline is first line for (3) and can also be used for ____

Answer 5

lyme disease, RMSF, vibrio; MRSA

Question 6

Aside from Jarisch Herxheimer rxn, what are general ADR’s of tetracyclines?

Answer 6

N/V/D, hepatic problems, candida, discoloration of teeth

Question 7

Black tongue is an additional ADR associated with ____

Answer 7

doxycycline

Question 8

Demeclocycline has a specific indication which is for patients who have _____ and its MOA is _____

Answer 8

SIADH, decreasing collecting ducts tubule response to ADH so that more water can be excreted

Question 9

Minocycline is similar to doxycycline except that it is more ______ and causes skin _______ with long term use

Answer 9

lipid soluble, hyperpigmentation (grey)

Question 10

Food and milk decreases tetracyclines ability to absorb by _____%. They as a class are also know to interact with vitamins and antacids by _____

Answer 10

50, chelation with certain ions (Al, Mg, Ca, Fe)