Mott Final Flashcards
Median Plane
Divides the body right in the middle into right and left
Sagittal Plane
Divides the body into left and right (anywhere)
Frontal (coronal) Plane
Divides the body into front and back
transverse Plane
Divides the body into upper and lower portions around the umbilical region
Bilateral
Both sides
Unilateral
One side
Ipsilateral
Same side
Contralateral
opposite side
Abduction
Away from the midline of the body
Adduction
Towards the midline of the body
Ventral Cavity consists of what cavities?
Thoracic, Abdominopelvic cavity
Dorsal Cavity consists of what cavities?
Cranial cavity, spinal cavity
What are cavities?
Large spaces that hold and protect organs
Tell me the 9 body regions from right upper to left lower
Right hypochondriac region,
Epigastric region,
Left hypochondriac region,
Right lumbar region,
Umbilical region,
Left lumbar region,
Right inguinal (iliac) region,
Hypogastric region,
Left inguinal (iliac) region
What organs are in the right upper quadrant?
Liver, Right Kidney, Gallbladder, some parts of the pancreas, Colon
What organs are in the left upper quadrant?
Stomach, Most parts of the pancreas, Spleen, Left kidney, Colon,
What organs are in the right lower quadrant?
Appendix, ureter, Colon, Small intestine, Major artery and vein to the right leg
What organs are in the left lower quadrant?
Colon, Small intestine, Major artery and vein to the left leg, Ureter
List the order from the smallest to biggest, (Cell –>)
Atom, molecule, macromolecule, organelle, cell, tissue, organ, organ system, organism (human)
What are the two types of cells?
Eukaryotic and Prokaryotic cells
What is the difference between Eukaryotic and Prokaryotic cells?
Eukaryotic cells have a distinct Nucleus and Prokaryotic have no clear nucleus. (Nuclear material is spread out)
Function of cell membrane
Keep the cell together
Give and maintain shape
separate from surrounding
responsible for allowing materials in and out of the cell (selective permeability)
What is the cell membrane made up of?
They are mostly made up of lipids
What is the cell membrane composed of?
Phospholipids, cholesterol, and proteins
What is special about the phospholipids of the cell membrane?
–It has a hydrophilic head where the phosphate group is negatively charged
–It has a hydrophobic tail where the lipid talks are uncharged
–Head is the outside and tail is inside.
What are transmembrane proteins? (Membrane proteins)
Protein that spans the membrane
What are receptors? (Membrane proteins)
Proteins found of extracellular surfaces
They selectively binds to specific molecules which translates to a specific reaction within the cell
What are channel proteins? (Membrane Proteins)
Allow select materials to pass in and out of the cell
What are glycoproteins? (Membrane proteins)
Proteins that have a carbohydrate molecule attached to it
What does the carbohydrate molecule do in the glycoprotein?
They work like a “name tag” for the cell,
It helps the cell “introduce itself” to other cells so they can recognize each other.
Carbohydrate molecule in the glycoprotein: It helps the cell “introduce itself” to other cells so they can recognize each other. Why is this important?
It is important for processes like the immune system to identify which cells belong in the body and which might be invaders.
What are two types of transport methods?
Active and Passive
What is Active transport
Requires energy, and it moves solutes from low to high concentration. (against the concentration gradient)
What is Passive transport?
Does not require energy and moves solutes from high to low concentration. (Down the concentration gradient)
Two types of Passive Transport
Diffusion and Osmosis
what is diffusion?
Solutes move from high to low concentration until they become equal.
Example of Diffusion
Moves oxygen from lungs to blood
CO2 from blood to lungs and eventually to outside air
What is Osmosis?
Movement of water from high to low concentration through a selective permeable
What does osmotic pressure do?
When there’s a difference in solute concentration on two sides of a membrane, water moves to “dilute the higher concentration.
Definition of Osmotic pressure
It is the pulling force created by the solutes to attract water to their side
What are the three types of Solutions?
Hypertonic
Hypotonic
Isotonic
What is hypertonic Solution?
Water rushes out of the cell, and the cell will shrink
More solute outside the cell
What is hypotonic Solution?
Water rushes into the cell, and the cell will burst
More solute inside the cell
What is Isotonic solution?
Equal amount of solute inside and outside the cell
What is filtration in passive transport?
Selective process, only solutes that can fit through the membrane will pass through
What is facilitated diffusion?
Diffusion in which a protein channel helps a substance move across the membrane.
What do the protein channels or carriers do in facilitated diffusion?
They act like doors to help larger or polar molecules across the membrane.
Diffusion is for»»
small, non-polar molecules across the cell membrane.
Facilitated diffusion is for»»
Large, polar molecules
What are two types of active transport?
Endocytosis and Exocytosis
What is Endocytosis?
In take of liquid and solid particles too large to cross the cell membrane
What is Exocytosis?
Transport out of the cell
How does Endocytosis bring in stuff into the cell?
Cell membrane will surround a small portion of the substance creating a vesicle
How does exocytosis transport stuff out of the cell?
Vesicle is moved towards the cell membrane to excel a substance
What is cytoplasm made of?
Water, salts and different organic molecules
Why do cells need cytoplasm?
Cells need cytoplasm for their internal environment for cell organelles to thrive and function
Function of Nucleus
Contains all of the cell’s chromosomes
Function of Nucleolus
To produce and assemble the cell’s ribosomes
Does Nucleolus have chromosomes?
No, because the nucleus has all the chromosomes
What is the other function of the Nucleolus? (Movement)
They shuttle ribosomes and ribosomal RNAs out of the nucleus and into the cytoplasm where protein synthesis occurs
Function of DNA
Carries genetic information for the development and function of an organism (human)
How is RNA different from DNA
DNA is double helix, but RNA is single strand
What does mRNA do?
Protein synthesis
What does rRNA do?
It is the structural components of the ribosome
Function of Rough ER
Responsible for protein synthesis and they are lined with ribosome (ribosomes are present)
Function of Smooth ER
Produces Lipids and steroids (no ribosomes present)
Which ER has ribosomes?
Rough ER
What is ribosomes made of?
RNA
Function of Ribosomes
Produce enzymes and proteins for cell repair and reproduction (make proteins)
What happens wehn Ribosome read the mRNA?
Ribosomes reads the mRNA sequence and It translates that genetic code into a specified string of amino acids, which grow into long chains that fold to form proteins.
What is the ribosome docking station for?
For tRNA that contains the amino acid that will then become part of the growing polypeptide chain, which eventually becomes the protein.
What do centrosomes contain?
Centrioles
What are centrioles involved in and what do they do?
Centrioles are involved in cell division and create the spindles used in cell division
Function of Mitochondria
Producer of ATP and is also involved in Apoptosis.
Cells that are more active will have more mitochondria.
How is the ATP produced?
Through Cellular respiration
Why can’t our body use the energy from the food we consume directly?
Because only food converted glucose can be used by cells.
What does glucose combine with, and where/what is it transformed t?
Glucose combines with oxygen and is transformed in the mitochondria into ATP.
During Cellular respiration, what is released when glucose is burned?
Glucose is burned in the presence of oxygen and makes water, Carbon Dioxide and lots of energy.
What happens when glucose is used up and energy is amde?
Carbon dioxide and water are made as waste products.
What do we need to make energy for the cells?
We must have glucose (from food) and abundant oxygen.
Why do we breathe? (related to cellular respiration)
Because we need to bring in oxygen to make energy and we need to exhale to get rid of the waste product CO2.
What is point of cellular respiration?
It is to make energy in the form of ATP
What is ATP made up of?
Base, sugar, and three phosphate groups
What is the function of the three phosphate groups?
They are held together by high-energy bonds and when a bond is broken, a high level of energy is realeased.
What happens to ATP when a bond is used up?
ATP becomes ADP which only has two phosphate groups`
What does ADP do after becoming ADP from ATP?
It can pick up another phosphate and form a high-energy bond so energy is stored and the process can begin again.
What happens during Glycolysis?
It partially breaks down a 6-carbon glucose molecule into 2, 3 carbon molecules of pyruvate and 2 net ATP
Where does Glycolysis occur?
In the cytoplasm
Does glycolysis need oxygen?
No
What does Transition Reaction do?
Transition Reaction connects glycolysis to the Krebs cycle
Where do the pyruvates enter and why does it have to?
The pyruvates must first enter mitochondria because the transition reaction and Krebs cycle happen in the matrix of mitochondria
What does the Krebs cycle do?
It completes the oxidation of glucose by taking pyruvates from glycolysis.
It breaks down the pyruvates into Carbon dioxide molecules and water molecules and generates additional ATP.
Where does krebs cycle occur?
Matrix of mitochondria
What is Anaerobic Respiration?
Breakdown sugars and produce energy without oxygen
Where does Anaerobic Respiration occur?
In the cytoplasm
Difference between Anaerobic and Aerobic Respiration
Anaerobic produce less energy, without oxygen.
Aerobic produces more energy, with oxygen.
Example of Anaerobic Respiration
Excercise really hard and muscles run out of oxygen
What is Aerobic Respiration?
Breakdown sugars and produce energy with oxygen
Where does Aerobic respiration happen?
Mitochondria
Example of Aerobic respiration
Normal breathing
Function of Golgi Apparatus
Packages and transport proteins
Where does Golgi Apparatus receive proteins from?
From the ER
Receives proteins from the ER –> Surrounds with a vesicle and secretes the protein (exocytosis)
Function of Lysosomes
Garbage disposal of the cell
Cleans up intracellular debris and waste through hydrolytic enzymes
What are the four macromolecules?
Carbs
Lipids
Protein
Nucleic acid
Types of Carbs (sugar)
Monosaccharides (simple sugars) Glucose
Disaccharides
Polysaccharides
What are simple carbs?
One or more sugars (monosaccharides or disaccharides) combined in a simple structure.
When are simple carbs used?
These are easily used for energy, causing a rapid rise in blood sugar and insulin secretion from the pancreas.
Examples of simple carbs
Candy, carbonated beverages,
corn syrup, fruit juice, honey, table sugar
What are complex carbs?
Three or more sugars bonded together in a more complex chemical structure.
Effects of Complex carbs
Complex carbs take longer to digest and, therefore, have a more gradual effect on the increase in blood sugar.
Examples of Complex carbs
Apples, broccoli, lentils, spinach, unrefined whole grains, brown rice
Two types of complex carbs
Starches and Fiber
What are starches (Polysaccharides)?
Starches are complex carbs that contain a large number of glucose molecules
What produces Starches (Polysaccharides) (examples)
Potatoes, chickpeas, pasta, and wheat
What are Fibers?
They are non-digestible complex carbs that encourage healthy bacterial growth in the colon and act as a bulking agent, easing defecation.
Two types of Fibers
Insoluble and soluble
Function of Insoluble Fibers
Absorbs water in the intestines and softening and bulking stool.
What are the benefits of Insoluble fibers?
Regularity of bowel movements and a decreased risk of diverticulosis
Function of Soluble Fibers
It helps decrease blood cholesterol and LDL levels (bad cholesterol), reduces straining with defecation
Examples of Soluble Fibers
Fleshy fruit, oats, broccoli, and dried beans
What do all carbs have?
1 carbon
2 hydrogen
1 oxygen
Function of Lipids
Energy storage, communication, and protection
What are lipids mainly made out of?
Carbon and hydrogen
Why are lipids hydrophobic?
Because they don’t have oxygen
What are saturated lipids at room temp?
They are solid at room temp
What are unsaturated lipids at room temp?
Typically liquid at room temp
What are steroids?
Cholesterol, a major precursor to many hormones
What are proteins made of?
Made of long chain of amino acids
Biochemical functions of Proteins
Enzymes and proteins accelerate a reaction as a catalyst to produce or breakdown biological molecules.
Structural Functions of proteins
Proteins serve as the structural elements of cells and tissues
Nucleic Acids
RNA and DNA
What do nucleic acids do?
Controls the activities of the cells
What do nucleic acids contain?
They contain our genetic code
What is metabolism?
All of the chemical operations going on within our bodies that provide the body with energy
What does metabolism need to function?
Nutrients (fuel)
What does metabolism produce?
Waste products
What are two types of Metabolism?
Anabolism and Catabolism
What is anabolism
Simpler compounds are built up and used to make materials for growth, repair, and reproduction.
(Building phase of metabolism) (water is removed)
What is Catabolism
Complex substances are broken down into simpler substances.
(Breaking down of substances) (water is added)
Carbs Metabolism (what is king)
Glucose is King
Carbs metabolism: They are stored in the body as what?
As glycogen until glucose is needed
What is glucose metabolized by?
Glycolysis
What is carbs metabolism regulated by?
Insulin
What are lipid Metabolism stored as in the body?
lipoproteins
What are lipid metabolism regulated by?
Insulin
What is “Forwards cholesterol metabolism” in lipid metabolism?
Cholesterol into the tissues
-LDL
What is “Reverse cholesterol metabolism” in lipid metabolism?
Cholesterol away from peripheral tissue back to the liver
Where does essential amino acids obtained from?
Must be obtained from diet since our body cannot produce it.
What is amino acid metabolism regulated by?
Cortisol and thyroid hormone
What is Cellular reproduction?
Process of making new cells
What must be copied before cell division?
All chromosomes
Where Eukaryotic cells found?
In the human body
What does Eukaryotic cells contain?
nucleus and chromosomes
How does Eukaryotic cells reproduce?
It uses mitosis to reproduce asexually
What is asexual reproduction?
Cells make identical copies of themselves without other cells
What does the cell cycle consist of?
Interphase and Mitotic phase
What phase does the cell spent the most time in?
Interphase
What happens in interphase?
Performs normal function
prepares for division by copying DNA, making organelles.
What is Mitotic phase consist of?
Mitosis and Cytokinesis
What is cytokinesis?
Division of the cytoplasm
What happens in transcription?
Info is moved from DNA to mRNA
What happens in translation?
mRNA is read to produce proteins
Why does transcription happen, or why does DNA create mRNA?
DNA holds the instructions for making proteins but dna can’t leave the nucleus.
So the cell makes a working copy of the instructions called mRNA which can leave the nucleus
Is mRNA an exact copy of the DNA?
Nope
Why is Transcription important?
Because the mRNA is a recipe or blue print for maing proteins
What is transcription in conclusion?
Transcription makes mRNA from DNA so the instruction can leave the nucleus and be used to make proteins in the cell.
Where does Translation occur?
Ribosome
What does mRNA do in the translation?
It carries the instructions from the DNA, a recipe that tells the ribosome how to build a protein.
How are proteins created?
By putting amino acids in the correct order.
What are codons in Translation?
The mRNA instruction are in “words” called codons, which are groups of three letters.
What does the codon represent in Translation?
Each codon represents specific amino acid
What is translation in conclusion?
It is like following a recipe in the ribosome factory, where mRNA tells the ribosome which amino acids to link together to build a protein.
Where are chromosomes located?
Inside the nucleus of animal and plant cells
What are chromosomes made of?
Protein and a single molecule of DNA
What are gametes?
They are the only human cells that do now contain pairs. (Reproductive cells)
How many chromosomes do humans hace?
23 pairs, 46
What is only inherited from the egg cell?
Mitochondrial DNA
What are centromeres?
Middle part of the chromosome that helps to keep the chromosome properly aligned in preparation for reproduction
What is the attachment site for the sister chromatids?
Centromere
What are Telomeres?
They are repetitive stretches of DNA located at the ends of the chromosomes
What do telomeres lose a bit of during every division?
DNA
What is Mitosis?
It is the process of sorting chromosomes
What happens in Prophase?
The nucleus disappears, the chromosomes become visible and spindle fibers form.
Centrosomes move towards opposite ends of cell.
What happens in Metaphase?
The chromosomes line up in the center of the cells.
What happens in Anaphase?
The chromosomes split and the spindle fibers pull them apart.
Sister chromatids break apart and begin moving toward opposite sides.
What happens in Telophase?
The chromosomes go to the far ends of the cell, the spindle fibers disappear, and the nuclei reappear.
Formation of 2 daughter nuclei
What happens after cytokinesis?
It forms two new identical daughter cells identical to the original mother cell.
G1
Cell growth
S phase
Cell replicates its genetic material in preparation for mitosis
G2
Cell checks duplicated chromosomes
What is the shortest stage in Mitosis?
Anaphase
Cytokinesis
Division of the cytoplasm
Cleavage furrow pinches cell in two
Mitosis regulation
Checkpoints that stops mitosis if certain conditions are not met
G1/S checkpoint
Restriction Checkpoint: Cell size, cell nutrition, DNA damage
G2/M checkpoint
DNA replication checkpoint: improper replication or damage
Metaphase/Anaphase checkpoint
Spindle Apparatus checkpoint: Attachment of mitotic spindle to all chromosomes
Two types of Tumors
Benign and malignant
Benign tumor
slow growing, non-life threatening, stays in the same place
Malignant tumor
Rapid growing, life-threatening, likely to spread to other tissues or metastasize (spread to other location)
Labile Cells
Constantly proliferating
Stable/Quiescent Cells
Typically in non-dividing state but can enter cell cycle under specific stimulus
Permanent Cells
Unable to proliferate, non-dividing
Ex: Cardiac and skeletal muscle
Homeostatsis
Maintenance of internal balance despite changes in the external environment
What happens when a person has impaired homeostatsis?
It underlies most disease processes
What is diabetes?
Disease of inadequate control of blood sugar (glucose levels in blood)
What is Type 1 Diabetes?
Destruction of cells that produce insulin
What is Type 2 Diabetes?
Insulin resistance (less responsive to insulin), attributed (causes) to excesses fatty acids
What causes the release of mitochondrial proteins into the cell which lead to apoptosis?
Cellular stress (from lack of exercise or increased calories)
What causes impairment of the electron transport chain and damage which cell organelle?
Excess calories
Damage to mitochondria
Metastasis
Spread of cancer cells from one location to another
Why does chemotherapy work on cancer cells?
Because cancer cells lack the ability to repair DNA whereas normal cells can
What cells do chemotherapy target?
Both healthy and cancerous cells.
Bone is a hard form of what?
Connective tissue
What are bones covered by?
Periosteum
What does the Periosteum do to the bone?
Nourish the external portion of skeletal tissue
Provide attachment site for ligaments and tendons
Two types of bone
Compact and Spongy bone
What is compact bone?
Dense, hard, tightly packed tissue
Where is compact found?
Found in shafts of long bones called diaphysis and outer layer of other bones
What does compact bone contain? (units)
Osteons (haversian systems)
-Mature bone cells (osteocytes) that form concentric circles around a central (Haversian) canal, containing blood vessels.
How are spongy bones arranged?
Arranged in bars and plates called trabecular.
What makes the spongy bone lighter?
Irregular holes between trabeculae and provide space for red bone marrow, which produces red blood cells.
Function of bone
Support
protection
movement
Storage
Blood supply production
When does ossification start and finish?
in the embryonic period (8 weeks) and finishes around age 20
What are the 4 types of bones?
long
flat
irregular
sesamoid
Does the bone have a high level of vascularization and where does blood enter?
Yes, it does.
Blood enters through the nutrient foramina to supply the bone marrow, spongy bone, and deep portions of compact bone.
Which part of the bone can sense pain signals and why?
Periosteum, because it is supplied by fibers that carry pain signals.
Why can’t inside of the bone sense pain?
Because the inside of a bone has limited amount of fibers that can detect pain.
What fibers regulate blood flow through the bone marrow?
Vasomotor fibers
What are the two main parts of the skeleton?
Axial and appendicular skeleton
What is axial skeleton consist of?
Head, neck, ribs, vertebral column
What is appendicular skeleton consist of?
arms, legs, hips, and shoulders
Nitrogen goes with which macromolecule?
Proteins
What bones live on tendons?
Sesamoid bone
How many vertebral regions do we have?
7 cervical, 12 thoracic, 5 lumbar, 5 sacral, 3-5 coccygeal
How many true ribs and false ribs do we have?
7 true ribs, 5 false ribs, 2 floating ribs
When does the spinal curvature change?
As infant learns to hold its head up and begin to walk, curving in the opposite direction.
How are both arms and legs attached to the axial skeleton?
They are attached via the pectoral and pelvic girdles
(Pectoral girdle: clavicle and scapula)
(Pelvic girdle: Pelvic bones)
What is Cartilage made of?
Dense connective tissue
What is a Joint?
articulation between bones
What is a ligament?
connects bone to bone
What can cartilage do?
It is a special form of dense connective tissue that can withstand a fair amount of flexing, tension, and pressure
Ex: Flexible parts of the nose and ears.
What does cartilage act as between bones?
it can act as a cushion between bones.
What does articular cartilage on ends of bone acts as?
It acts as a shock absorber, preventing the ends from grinding together.
What are three types of joints?
Synovial Joints
Fibrous Joints
Cartilaginous Joints
What are Synovial Joints?
Surrounded by a joint capsule and line with synovial fluid
What are fibrous Joints?
Where bones are connected by a dense, tough connective tissue.
What type of movement does Fibrous joints provide?
Limited amount of movement
What does Cartilaginous joints do?
Give shock absorption as well as flexibility.
What are the six types of Synovial Joints?
Plane
Hinge
Saddle
Condyloid
Ball and socket
Pivot
What movement do plane joints provide?
Gliding or sliding (Carpal and Tarsal joints)
Gun shooting motion
What movement do Hinge joints provide?
Only flexion and Extension movement
Ex: Elbow, knee
What movement do saddle joints provide?
Allows movement in 2 planes, opposition movement
Ex: touching your thumb with other digits
What movement do Condyloid joints provide?
Flexion and extension, aDDuction and ABduction, circumduction
Ex: Elbow, knuckle joint
What movement do Ball and Socket Joints provide?
Movement in all planes
Ex: Shoulder and hip joint
What movement do Pivot joints provide?
Rotation
Ex: Rotating your palm forward/backwards, Rotating the neck
What is Joint (articulation) necessary for?
Movement
Where is the joint located?
It is where two or more bones join together
What do ligaments do?
Permit joints to move
What are fibrous joints held together by?
Short connective tissue strands
Are fibrous joints movable?
They are either immobile or slightly movable
Example of Fibrous joint
Sutures in the skull
What are cartilaginous joints held together by?
Cartilage
Are cartilaginous joints movable?
Either immobile or slightly movable
Examples of Cartilaginous joints
Pubic symphysis and joints between the ribs and sternum
Are synovial joints movable?
They are freely movable
Where is Epiphysis located?
End of a long bone