Mononucleosis Session 93

Question 1

Hallmark of EBV infection

Answer 1

polyclonal B cell proliferation

Question 2

Incidence of MONO is greatest…

Answer 2

2nd decade exposure to EBV

Question 3

Process of IM

Answer 3

incubation 1-2 months
lymporeticular dissemination
Prodromal 2-5 days
symmetrical lymphadenopathy
Palatal exanthem

Question 4

What immune cell increases and cause smptoms

Answer 4

B and T cells proliferate
T cells ar eatypical Downey bodies
T cell response causes disease

Question 5

IM Agent Structure

Answer 5

Gamma Herpevirus
Envelope Ds Stranded DNA genome
Latenc in B cells
EBV 1 EBV 2

Question 6

EBV Epidemiology

Answer 6

Person 2 Person
Replicated in B cells, shed into SALIVA
1 month or life
KISSING Disease
Low contagious

Question 7

Peak age of incidence HBV

Answer 7

17-25

Question 8

EBV Latency

Answer 8

10 genes are expressed during latency ( differnt than HSV)

Question 9

EBV Diagnosis

Answer 9

Presence atypical lymphocytes
Heterophile antibodies present in IM
IgM heterophile, paul-bunnell on rbc
MONOSPOT
serology tests useful for infants and small children
IgG are permanent

Question 10

IM Treatment

Answer 10

symptomatic relief

Question 11

IM complications

Answer 11

rash w/ amox

Splenic rupture, NOT COMMON

Question 12

Post transplatn Lymphoproliferative disease

Answer 12

immune suppressed,

virus exposure or latency reactivation

Question 13

Burkitt Lymphoma

Answer 13

dysregulation of c-MYC, EBV is co-contributory

Question 14

Non hogkins lymphoma

Answer 14

HIV and transplant receivein cyclosporin A

Question 15

Hodgkins Disease

Answer 15

EBV role in pathogenesis

Question 16

CMV affects what population the most

Answer 16

Infants,

Also transplant and HIV

Question 17

Family of virus is CMV

Answer 17

betaherpes virus

Question 18

CMV Epidemiology

Answer 18

Very young or elderly
Endemic
No seasonal
Person to Person
Adult contact with Children( DAYCARE )

Question 19

CMV Clinical Manifestations

Answer 19

Disseminate via lymphocytes

Question 20

Adult CMV Manifestions

Answer 20

Antibody heterophile NEGATIVE

Atypical Lymphocyte positive

Question 21

Transplacental CMV Manifestations

Answer 21

Primary or reactivate of Mother

Question 22

Transfusion/Transplant CMV manifestation

Answer 22

Reactivation of virus in host

Question 23

HIV pateient CMV manifestation

Answer 23

Retinitis
GI
CNS diesease
Pneumonias

Question 24

CMV Diagnosis

Answer 24

TORCH
Serology
Viral Culture
Viral Antigen

Question 25

When do you suspect CMV?

Answer 25

Symptoms of IM, negative for heterophile, and EBV specific antigens Signs of hepatitis but neg for A B C

Question 26

CMV Treatment

Answer 26

Gancicyclovir Foscarnet Formivirisen

Question 27

MUMPS

Answer 27

Paramyxovirus Linear ssRNA - sense Enveloped Virus has spikes

Question 28

Mumps Clinical Manifestations

Answer 28

``` Acute infection salivary glands w/ fever RAPID onset Can be asymptomatic Spread to other organs i.e. CNS Can develop Orchitis ```

Question 29

MUMPS Diagnosis

Answer 29

febrile w/ bilateral parotitis | HA assay with infected tissue sample

Question 30

MUMPS Epidemiology

Answer 30

Only natural host is HUMAN HIGHLY COMMUNICABLE use to be endemic

Question 31

Mumps Complications

Answer 31

Deafness Orchitis oophoritus mastitis

Question 32

Mumps Treatment

Answer 32

Not antvirals | symptomatic relief

Question 33

Mumps Prevention

Answer 33

MMR Jeryl Lynn Attenuated virus Not for egg or neomycin sensitive