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MICRO Exam 7 > HTLV HIV 91-92 > Flashcards

HTLV HIV 91-92 Flashcards

1
Q

HTLV

A

Enveloped
diploid
+ ssRNA
Icosahedral

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2
Q

HIV

A

Enveleoped
Diploid
+ssRNA
Helical

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3
Q

HIV HTLV Mechanism

A

Reverse Transcriptase RNA –> DNA

Integrase–> into host genome

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4
Q

Two genera of viruses that infect humans

A

Lentiviruses

Oncoviruses

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5
Q

What links to HTLV 1

A

T cell leukemia

HAM/TSP

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6
Q

What links to HTLV 2

A

Milder neurologic

Pulmonary disorders

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7
Q

HIV Structure

A 
Membrane proteins gp 120 and gp 41
Helical
Core matrix/ Proteins
Enzymes; protease, integrase, transcriptase
RNA diploid
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8
Q

HIV genomes

A

gag
pol
env

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9
Q

Gag of HIV codes for

A

capsid, core and matrix proteins

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10
Q

Pol of HIV codes for

A

Three viral enzymes

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11
Q

ENV of HIV codes for

A

Two envelope glycoproteins

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12
Q

Receptors used for entry in HIV

A

CD4
CXC R4
CCR5

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13
Q

Host Cells that HIV gain access

A

T Lymphocytes
Monocytes
Dendritic Cells

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14
Q

HIV binds what receptor in Dendritic?

A

DC SIGN– high affinity for ICAM-3

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15
Q

7 steps of HIV life cycle

A
  1. Fusion
  2. Nucleoscapsid
  3. RNA converted to DNA
  4. v dNA into nucleus
    5 activation, transcription into genome
  5. Assembly and budding new virion
  6. Maturation into infectious virion
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16
Q

4 stages from infection to AIDS

A
  1. ACUTE HIV INFECTION
  2. Clinical Latency
  3. Early symptomatic HIV INFECTION
  4. AIDS
17
Q

ACUTE HIV INFECTION

A

Infection of mononuclear cells

Mimic Infleunza

18
Q

ClINICAL LATENCY IN HIV

A

asymptomatic
continure preogression and replication HIV in cells
Gradual Decline in T cells

19
Q

Early Symptomatic HIV infection

A 
CHRONIC SYMPTOMS/INFECTIONS
hairy leukoplakia
Gingivitis
p neuropathy
lymphadenopathy
DECREASE CD4 & Increase viral load
Infections not AIDS definig
20
Q

Which two infections are not AIDS defining?

A

Oral candidiasis

SHINGLES

21
Q

AID of HIV

A

HIV + AND
AIDS defining illness OR
CD4 count < 14%

22
Q

What three illnesses are indicative of AIDS

A

Kaposi
Pneumocyti Jirovecci
Cryptococcus

23
Q

Neurologic manifestations

A

HIV encephalopathy
P Neuropathies
AIDS dementia complex

24
Q

HIV transmission

A 
Blood Semen
vaginal 
breast milk
SEXUAL CONTACT
IVDU
25
Q

Three Categories of Clinical Diagnosis of HIV

A

A: Acute and Latency
B:Infections early stages
C: AIDS defining illnesses

26
Q

LAB DIANOSIS

A

Detection of anti-HIV

  • Rapid Test
  • ELISA
27
Q

Assess Viral Load vis what?

A

NATs (effective treatment)

28
Q

Monitor Drug progression

A

TCD4 : TCD8 ration 1:1 - 6:1

If CD8 ? CD 4

29
Q

What is PCR good for HIV

A
  1. Viral Load
  2. Diagnosis
  3. drug effectiveness
30
Q

Classes of Treatment of HIV

A
  1. two classes of RT
  2. protease inhibitors
  3. integrase inhibitors
  4. fusion/entry inhibitor
31
Q

HTLV Structure

A

HTLV-1 w/ human infections

Not cytolytic and persist long times

32
Q

HTLV Genome

A

Same as HIV +2 genes

  1. tax
  2. HBZ
33
Q

What do HTLV genes tax and HBZ do?

A

growth and proliferation

34
Q

HTLV Clinical Manifestations

A
  1. Adult T Cell Leukemia
  2. HAM/TSP
  3. Uveitis
35
Q

HTLV pathogenesis

A

CD 4 T cells

Tax leads to clonal ploriferation immortalization

36
Q

Function of Tax gene HTLV

A
  1. secrete cytokine growth factors (IL 2 proliferat T cells)
  2. disrupts normal progression of cell cycle
37
Q

Function of HBZ HTLV

A

If cell loses tax,they evade immunity

HBZ maintains oncogenesis in tax absent genes

38
Q

HTLV Mode of transmission

A

IVDU
Blood
Sexual Transmission

39
Q

HTLV Diagnosis

A

detection of ag or ab ELISA
Atypical Lymphocytes
Elevated WBC
Patient History

MICRO Exam 7 (14 decks)

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