Bacterial Zoonotic

Question 1

Cause of Tularemia

Answer 1

Franciscella Tularensis

Question 2

Franciscella Epidemiology

Answer 2

Northern Hemishpere
Summer (Ticks)
Winter (rabbitts)
Vectors: Ticks and deer flies

Question 3

Characteristics of Tularemia

Answer 3

Fastidious, aerobe 
COCCOBACILLUS
Facult Intracellular 
Like Macrophages
Extended life in mud and carcasses

Question 4

Method of Transmission Tularemia

Answer 4

Arthropod bite
Direct animal contact
Aerosol
Incontaminated Water
Undercooked meat
Small Mammal Bite
NO PERSON TO PERSON

Question 5

Alinical of arthropod

Answer 5

Ulceroglandular

Question 6

Inhalation

Answer 6

Pneumonic

Question 7

INgestion of meat

Answer 7

Oropharyngeal

Question 8

Systemic Spread

Answer 8

Typhoidal

Question 9

Autoinoculation

Answer 9

Oculoglandular

Question 10

Ulceroglandular Tularemia

Answer 10

Most Common, Rarely fatal
Through Skin,
Inhibits lysosome phagosome fusion; macrophages
2-5 days painful papule
Lymphadenopathy
Abrupt Onset
Spread

Question 11

Pneumonic Tularemia

Answer 11

High Mortality
Inhaled, multiple necrotizing granulomas
Broncho pneumonia, Bronchitis, Tracheitis
Lobar Pneumonia
Bacteremia

Question 12

Oropharyngeal Tularemia

Answer 12

Bacteria Ingested
Bloodstream
Endotoxemia
Fever sore throat
splenomegaly

Question 13

Oculoglandar

Answer 13

Rare form
Bacteria ioculated in eye
Conjuctival sac
Photophobia
mucopurulent discharge

Question 14

Typhoidal

Answer 14

Mortality is HIGH
Systemic bloodstream
Sepsis
Pneumonia

Question 15

Diagnosis of Tularemia

Answer 15

Culture aspirate lymph node
Special AGAR
4x increase in IgG
Antibodies cross react w/ brucella

Question 16

Tularemia Treatment

Answer 16

Streptomycin

Doxyclcline–> relapse

Question 17

Tularemia Prevention

Answer 17

Avoid Reservoirs and vecotrs
process in biohazard hood
live vaccine not great but reduces severity

Question 18

Brucellosis subtypes

Answer 18

Abortus—-cattle

Melitensis— goats and sheep

Question 19

Brucella Characteristics

Answer 19

gra neg aerobic
facultative intracellular
Range of presentation
Cure to abscess

Question 20

Brucella Epidemiology

Answer 20

Control in animal = control in humans

Unpasteurized milk

Question 21

Brucella disease presentation

Answer 21

Patient HIstory
Ingestion or animal contact
Spread via lymphatic, multiplies macrophages, becomes systemic
UNDULATING FEVER

Question 22

Burcella Disease

Answer 22

Fever Back Pain Fatigue
Abscesses and Granulomas
Arthritis Respiratory Cardiovacular

Question 23

Burcella Diagnosis

Answer 23

Lab notification
Culture various tissues
Serological tests
MIsdiagnose as mylaria or Flu

Question 24

Burcella Characteristics

Answer 24

Obligate aerobe,
gram neg
coccobacillus
weak Lps
no motitliy
cat, ox and urease positive
Prefers Macrophages
Survival in milk, fetuses aborted,  soil, or paper

Question 25

Burcella Treatment

Answer 25

Doxycicline w/ rifampin | 6+ weeks

Question 26

Burcella Prevention

Answer 26

Immunization of animals | Avoid unpasteurized

Question 27

Batonella Bacilliformis

Answer 27

bartonellosis, oroya fever

Question 28

Bartonella quintana

Answer 28

trench fever, angiomatosis

Question 29

Bartonella Henselae

Answer 29

Cat Scratch

Question 30

Bartonella elizabethae

Answer 30

endocarditis

Question 31

Bartonella Characteristics

Answer 31

gram neg aerobic bacillus Facult intracellular of blood and RES Motility vaires

Question 32

Bartonella Epidemiology

Answer 32

Bacilliformis--- s america only Henselae---- cat host, others are human hosted Bite by arthropod Bite or scratch by Cat

Question 33

Vector Bacilliformis

Answer 33

sandfly

Question 34

vector henselae

Answer 34

cat flea

Question 35

vector quintana

Answer 35

Body Louse

Question 36

Bacilliformis

Answer 36

``` biphasic Oroya fever (Acute) Verruga (Chronic) Sandfly Bloodstream multipilcation Oroya fever by removal RBC by REC\ Fever Malaise, Myalgia, Headache ANEMIA ```

Question 37

Presentation of Verruga

Answer 37

Red purple skin lesions | Recurrence

Question 38

Quintana

Answer 38

``` Trench Fever, Body Louse transmission Multiply in RES sever headache abrupt presentation 5 day recurrence ```

Question 39

Henselae

Answer 39

Marcophages and lymphnodes Bacteremia septicemia occur in immunocompromised Chronic regional lymphadenopathy

Question 40

Angiomatosis

Answer 40

Quintana or Henselae | immunocompromised

Question 41

Diagnosis

Answer 41

History | serology DFA IFA

Question 42

Bartonella Treatment

Answer 42

Azithromycin Doxycycline Macrolides Doxycycline

Question 43

Cat Scrach Tx

Answer 43

Azithro

Question 44

Bartonellosis

Answer 44

Doxycycline or Chloraphenicol

Question 45

Angiomatosis Tx

Answer 45

Macrolides

Question 46

Trench Fever Tx

Answer 46

Doxycycline