Module 9 Flashcards
What are the functions of the skeletal system?
- support
- protection
- movement
- mineral homeostasis
- hematopoiesis
- fat (energy) storage
The _______ is a bone stem cell and is the precursor to other bone cell types.
osteogenic cell
_______ are dividing cells. They are responsible for laying down the components of bone; we can distinguish them from other cells which all start with “osteo-“ by remembering that they are Bone Building Blasts.
Osteoblasts
Within spaces inside of bone, _______ (“bone cells”) maintain bone integrity.
osteocytes
Bone-Chewing _______ constantly tunnel through bone, dissolving the bone matrix as they go.
osteoclasts
What are the 4 cell types found in bone?
osteogenic;
osteoblast;
osteosyte;
osteoclast
Osteoblast and osteoclast activity is regulated by ______.
hormones
What are the 2 components of bone?
inorganic and organic
The inorganic portion of bone is primarily a mineral called ________, a compound of calcium, phosphate and hydroxyl groups.
hydroxyapatite
Bone is a composite material. The inorganic portion is ______. The organic portion is _______.
inorganic = mineralized; organic = protein
If the bone has too much mineral, it becomes brittle and fractures easily. This happens in the disease _______, or “brittle bone disease”.
osteogenesis imperfecta
If the bone has too much collagen, bones are soft and pliable, as in children with ______ or adults with _____.
rickets;
osteamalacia
What are the 2 main TYPES of bone?
spongy and compact
______ is, as the name suggests, compact. This hard, dense tissue provides structural support. It accounts for 80% of the total bone mass.
Compact bone
The basic structural unit of compact bone is the _____.
osteon
Each osteon consists of a series of concentric rings called ______. In the center of this structure is a canal that runs the length of the bone, carrying blood and lymphatic vessels.
lamellae (latin: thin plate)
Small spaces between the lamellae contain the osteocytes. Small channels (________) join adjacent lacunae.
canaliculi (latin: small canals)
______ (Volkman canals) run radially in long bones to join adjacent central canals.
Perforating canals
______ is found in the marrow cavity of long bones like the femur and humerus.
Spongy bone
_____ bone marrow is where blood cells are made.
red
_____ bone marrow is where fat is stored as energy.
yellow
Spongy bone is made up of _______.
trabeculae (latin: “little roof beam”)
The skeletal system is not all compact bone or spongy bone. Much of the skeleton is made up of ______.
cartilage
_______ gets its name from its resemblance to glass, shiny and translucent. It has a great deal of ground substance with no apparent structure, and the living cells that lay down cartilage are found in little spaces, again called lacunae, here and there amongst the glassy ground substance.
Hyaline cartilage
______ is, of course, more fibrous in appearance and structure. The ground substance has collagen fibers running through it. This is found in the disks between vertebrae; in the pubic symphysis where 2 halves of the pelvis are joined; and in the menisci of joints.
Fibrocartilage
______ has elastin fibers in place of the collagen fibers found in fibrocartilage, but otherwise, it has a similar structure. It is found in the ear and epiglottis, 2 structures that need to be flexible and snap back into shape when moved and released.
Elastic cartilage
What are the 3 types of cartilage found in the skeletal system?
Hyaline cartilage;
Fibrocartilage;
Elastic cartilage
Dense regular connective tissue is represented in the skeletal system by ______, band-like structures that strap one bone to another.
ligaments
A very important dense irregular connective tissue in the skeletal system is the _______, a thin membrane that surrounds all bones.
periosteum
The _______ lines the medullary cavity.
endosteum
_____ bones are longer than they are wide.
Long
Either end of the long bone has an ______; these are the knobby ends of the bone and form joint surfaces.
epiphysis (epi- “on top of”, -physis “nature”)
In the middle of the long bone is the _____. This is the shaft of the long bone.
diaphysis (dia- “through”, -physis “nature”)
Between the epiphysis and diaphysis is a transition in the middle, or ______.
metaphysis
`The specialized region inside the epiphysis is the _________. This is the site of bone growth as these long bones grow during development.
epiphyseal plate
In adults, who are done growing in height, the remnant of the epiphyseal plate is seen as the _______. It is often possible to see this as a landmark in conventional x-rays.
epiphyseal line
The growth of long bones at the epiphyseal plate, and the growth of bones in many other places, occurs through _______. This uses a cartilage “model” to shape the bone; the cartilage is eventually replaced with compact or spongy bone.
endochondral bone formation
In fetuses and very young children, many of the future bones are completely cartilaginous. At some point, a _______ appears in the center of the forming bone, where the diaphysis will be.
primary ossification center
Later in life, a ________ will develop near the joint surface.
secondary ossification center
Endochondral bone formation is one strategy. The other strategy used to form bone is _________.
intramembranous bone formation
In the intramembranous bone formation strategy, instead of a primary and secondary ossification center in the middle and ends of the bone, there are multiple ______ that start as islands and then spread outward. As they spread, they form spongy bone.
ossification centers
________ make bone. They lay down the organic and inorganic extracellular matrix of the bone. They are bone Builders.
Osteoblasts
______ break bone into pieces. They are bone Chewers.
Osteoclasts
_______ is released from a set of small, pea-shaped glands next to the thyroid. This hormone increases osteoclastic activity.
Parathyroid Hormone (PTH)
______ is made by parafollicular cells (C cells) in the thyroid gland. It is released when calcium is high, and inhibits osteoclasts.
Calcitonin
______ is hormonally active Vitamin D. It is released from the kidneys when blood calcium is too low. It works in the digestive system to increase the absorption of calcium from foods.
Calcitriol
What are the 2 D vitamins?
Vitamin D2 (ergocalciferol); Vitamin D3 (cholecalciferol)
The elderly may have very low levels of hGH and tend to have problems with calcium absorption and homeostasis. This may result in the disease _____, which weakens bones.
osteoporosis
The ______ consists of those bones that are in the center of the body, from head to coccyx. That is - the skull, vertebrae, ribs and sternum.
axial skeleton
The _______ is bones that form the structure of the upper and lower extremities. Thus, the bones of the arm, forearm, wrist, and hand, but we include the scapula and clavicle because these stabilize the shoulder girdle. Also, the bones of the thigh, leg, ankle, and foot. The pelvis is part of the lower extremity, as well, because it stabilizes the lower extremity and forms the socket of the hip joint.
appendicular skeleton
_____ are about as long as they are wide. They are shaped like a wooden block or a lego. They include the carpal bones of the wrist and the tarsal bones of the ankle.
Short bones
______ are the bone equivalent of the squamous cells; they are wide and thin. The sternum is an example.
Flat bones
_____ are a garbage category for bones that don’t have any definable shape. An example would be the vertebrae.
Irregular bones
A _____ is a small, round, flat bone that can arise as the result of mechanical stress or trauma to muscle. The only example is the patella.
sesamoid bone
orbit of the eye
lacrimal bone
upper jawbone
maxilla
lower jawbone
mandible
cheekbones
zygomatic bones
interior upper ceiling of the nasal sinuses
ethmoid bone
a horseshoe-shaped, “floating” bone in the neck
hyoid bone
small bone that forms the bridge of the nose
nasal bone
forms the roof of the mouth (hard palate)
palatine bone
In order for blood vessels to pass in and out of the skull, it is necessary to have large and small holes in the skull. These holes are called _______. There are also shallow depressions called ________.
holes = foramina (latin: "hole"); depressions = fossae (latin: "ditch")
In the nasal sinuses, nerves carrying smell information pass through _____ in the sponge-like _______.
olfactory foramina;
cribiform plate
In the sphenoid bone, the ______ forms a hole for the optic nerve to pass from the eye to the brain.
optic foramen
The ______ forms a ditch that holds the pituitary gland (hypophysis).
hypophyseal fossa
An oval-shaped hole (______) allows the passage of several nerves and blood vessels.
foramen ovale
The _____ of the occipital bone, a huge hole allows the spinal cord to exit the skull.
foramen magnum