Module 4 Flashcards
The ____ is the basic unit of all living things.
cell
_______ _____ are complex cells with a membrane bound nucleus and subcellular structures (organelles).
Eukaryotic cells
All fungi, plant, and animals are ______.
eukaryotes
_______ ______ are simple cells and most are unicellular.
Prokaryotic cells
_____ includes bacteria and don’t have a true nucleus.
Prokaryotes
The _____ _____ is a covering that regulates what comes into or leaves form the cell.
plasma membrane
The _____ is a mixture of water, salts, proteins, and organelles.
cytoplasm
The ____ is the control center of the cell. DNA and RNA are made here.
nucleus
What are the 3 main parts of eukaryotic cells?
- plasma membrane
- cytoplasm
- nucleus
The _____ _____ is also called “membrane” or “plasmslemma”.
plasma membrane
The ______ is a gelatin-like substance, plus structural fibers and organelles (but not the nucleus)
cytoplasm
The ____ contains the genetic library for the cell.
nucleus
The _____ _____ covers and protects the cell, controls what goes in and comes out, links to other cells, tells other cells who it is (flies a flag).
plasma membrane
The _______ gives it’s cell shape, contains structural (cytoskeletal) proteins, comprised of organelles (except nucleus) and cytosol.
cytoplasm
The ______ is where the genetic information is stored (the library with cookbooks entitled “How to Make a New Cell”, “How to Make the Proteins You Need”, etc…
nucleus
_____ is the genetic material that must be reproduced and read without error, and is generally never altered or destroyed.
DNA
_____ is made in the nucleus and exported into the cytoplasm, where it carries out its work: making proteins.
RNA
The new model for the cell membrane, which cam to be called the ______-_______ ______ features a lipid “sea” with protein “icebergs” floating in it and proteins which are integral or peripheral.
fluid-mosaic model
The lipids in the plasma membrane consist of ______ or ______ heads and ______ or ________ tails.
polar / hydrophillic heads;
non-polar / hydrophobic tails
_____ means embedded in bilayer, go from one side to the other.
Integral
_____ means it is associated with the inside or outside of the cell.
Peripheral
If the peripheral is _____ the cell, it links the cytoskeleton to the membrane.
inside
If the peripheral is ______ the cell, it links the cell to connective tissue or to other cells.
outside
_____ _____ ______ are loosely associated with the cell membrane and lie either completely on the outside or completely on the inside of the cell.
Peripheral membrane proteins
______ (________) ______ span the cell membrane from outside to inside the cell.
Integral (transmembrane) proteins
_______ tells us how easily a substance can cross the plasma membrane.
Permeability
______ ______ is what defines a cell
Differential permeability
What is the rule of thumb regarding selectively permeable?
small, neutrally charged, lipid-soluble substance can pass without assistance.
What are the 6 functional classes of membrane proteins?
- ion channels
- carriers
- receptors
- enzymes
- linkers
- cell identity markers
____ _____ are integral and forms a pore through which a specific ion can flow to get across the membrane.
Ion channels
____ are integral and transports a specific substance across the membrane by undergoing a change in shape. These are also known as transporters.
Carriers
_____ are integral and recognizes specific ligand and alters cell’s function in some way.
Receptors
_____ are integral and peripheral and catalyzes a reaction inside or outside the cell (depending on which direction the active site faces).
Enzymes
_____ are integral and peripheral and anchors filaments inside and outside the plasma membrane, providing structural stability and shape for the cell.
Linkers
___ ____ _____ are glycoprotein and distinguishes your cells from anyone else’s (unless you are an identical twin). An important class of such markers are the major histocompatibility (MHC) proteins.
Cell identity markers
The non-polar tails of lipid molecules prevent charged molecules, like ions, from crossing the cell membrane. ____ ____ allow ions to pass DOWN their concentration gradient (high to low). Some are open all the time, others are gated (open and close on demand).
Ion channels
Protein _____ can be transporters or pumps. Many molecules that cannot cross the cell membrane are “ferried”. This can occur up or down the concentration gradient. If it occurs against the gradient, energy is required. Energy comes from ATP and other molecules that run down their concentration gradient.
carriers
The signaling molecule that binds to the receptor is called a ______.
ligand
The process by which a signal outside the cell is transformed into a charge inside the cell is called _____ ______.
signal transduction
_______ signals outside the cell can affect activities inside the cell. The cell uses these to detect an extracellular signal and transduce it to an intracellular signal.
Receptors
Enzymes can’t and don’t change the energy profile of the reaction, but instead lower the ______ ______.
activation energy
_______ are proteins that catalyze (speed up) chemical reactions. The ones on the cell surface catalyze chemical reactions there.
Enzymes
______ link intracellular and extracellular structures. The internal structure of the cell must be connected to the connective tissues outside the cell. They join proteins inside and outside the cell.
Linkers
Most cell markers consist of a complex, branched sugar polymer attached to a transmembrane protein. This combination is called a _______.
glycoprotein
____ _____ are a way to identify cells that belong to you, and what organ they belong to. Sugars connected to proteins are commonly used as “flags”.
Cell markers
______ transport moves substance “downhill” or “with” a gradient (high to low) and does not require energy.
Passive
_____ diffusion and _____ diffusion is the movement of solutes.
Simple and facilitated
_____ is the movement of solvent.
osmosis
When both solutes and solvents are being moved, it is referred to as _______.
filtration
Molecules in a liquid or gaseous medium tend to spread themselves out evenly throughout the volume of the container. We call this _______.
diffusion
______ diffusion is used to move substances such as glucose and various ions DOWN their concentration gradients.
Facilitated
_____ diffusion allows molecules in a gas or liquid to move around. The warmer the temperature, the more movement. The smaller the molecule, the more movement. Over time, the concentration of the substance will become equal in all parts of the system. It is the random motion of small particles in a solution (Brownian motion).
Simple
Facilitated diffusion uses protein ____ or ____ in the cell membrane to facilitate the diffusion.
carriers or channels
When we combine diffusion of water with a semi-permeable membrane, we get _____.
osmosis
Osmosis is the term that describes the diffusion of solvents across a _____-________ membrane.
semi-permeable
The ______ _______ is the pressure required to nullify the movement of water through the membrane.
osmotic pressure
______ describes the concentration of solutes and is a measure of the effective osmotic pressure.
Tonicity
A _______ solution = high salt concentration = low water concentration.
Hypertonic
A ______ solution = low salt concentration = high water concentration.
hypotonic
An _____ solution = no net movement of water. The water concentration is the same inside and outside the cell.
isotonic
In ____ solutions, the concentration of solutes is lower outside the cell than inside.
hypotonic
In ______ solutions, the concentration of solutes is higher outside the cell than inside.
hypertonic
When red blood cells shrink in a hypertonic solution, we say they _____: they take on a spiny shape, which is not good if the RBC needs to slide easily through blood vessels.
crenate
The medium - pure water - has fewer solutes than the inside of cells. Therefore, the medium is _______ to the cells and the cells swell and burst.
hypotonic
The medium - 0.85% salt water - has the same number of particles in the solution as the inside of the cells. Therefore, the medium is _______ to the cells. They neither shrink nor burst.
isotonic
The medium - 3% salt water - has more particles in the solution than inside the cells. Therefore, the medium is _______ to the cells and the cells lose water and shrink.
hypertonic
______ is another type of passive transport. Solutes and colloids pass through a barrier based on size.
Filtration
Each filtration medium (for example, filter paper in a coffee maker) has a “_____ _____”.
pore size
_____ sorts particles based on size.
Filtration
_____ transport moves substances “uphill” or “against” its concentration gradient (low to high), requires energy from ATP (directly or indirectly). It’s energy sources are ATP or pre-existing storage of energy in a concentration gradient (potential energy).
Active
_____ ______ transport is when molecules are moved against their concentration gradient (low to high), energy is required, ATP or existing ionic gradient are energy sources.
Primary Active
The sodium / potassium pump is _____, since 3 positive charges are pumped out for every 2 allowed in.
electrogenic
______ ______ transport involves two types of carrier proteins, symporters and antiporters.
Secondary active
In an ______ system, two ions move in opposite directions.
antiport
In a ______ system, a molecule and an ion move in the same direction.
symport
In ______ active transport, we use the energy stored in the sodium concentration gradient established by primary active transport to move other solutes against their gradient.
secondary
Active transport uses _______ and _______ to take in and discard things needed or not needed by the cell.
endocytosis; exocytosis
During ______, the cell surface proteins (receptors) can bind molecules the cell wants to take in. After the material binds to the receptor, it is taken into the cell. This is a type of vesicluar transport.
endocytosis
In _____-_____ _____, cell surface proteins (receptor proteins) bind a substance of interest, and then signal the cell to begin the process of pinching off a vesicle.
receptor-mediated endocytosis
_____ and _____ are a type of endocytosis.
phagocytosis and pinocytosis
______ is an important defense of the body against invaders. When invaders are detected, specialized white blood cells surround and kill the invading cells.
Phagocytosis
_______ is the cell’s way of eating things. It is a specific form of endocytosis.
Phagocytosis
______ is akin to phagocytosis, but is used to bring liquids into the cell.
Pinocytosis
Pinocytosis is also called ____-____ _____.
bulk-phase endocytosis
In _______, the cell makes a pit, then seals it. In the process, a vesicleful of liquid is incorporated into the cell.
pinocytosis
_______ is like phagocytosis, but for liquids instead of solids. The cell forms a pit, then seals it, “swallowing” a tiny ball of liquid. It is non-specific.
Pinocytosis
______ is used to send materials out of the cell in bulk.
Exocytosis
______ is an active process which requires ATP for energy. It is a type of vesicular transport. It’s like endocytosis but in reverse.
Exocytosis
Recall that cells “fly a flag” with cell surface markers. These markers are placed on the cell membrane by ______.
exocytosis
Think of the _____ as a fruitcake because it is comprised of a soluble part (cytosol) plus large, semi-independent parts (organelles).
cytoplasm
_____ is made up of water, solutes, suspended particles, lipid droplets and glycogen granules.
Cytosol
_______is the solvent (water) and solutes (salts and dissolved proteins) that make up the soluble part of the cytoplasm (it’s the cake part of a fruitcake).
Cytosol
Cytoplasm is the cytosol plus ______. The ______ are the fruits and nuts in the fruitcake.
organelles (for both)
The business of the cell is carried out by the _______.
organelles
Just like the skeleton gives the body a shape and structural stability, the _______ gives the cell shape and structural ability.
cytoskeleton
What are the 5 main divisions of organelle function?
- structural integrity
- motility
- synthesis
- storage and digestion
- energy production
______ are specialized structures with characteristic shapes. Each one has specific functions.
Organelles
_______ is a network of three types of protein filaments: microfilaments, intermediate filaments, and microtubules. It maintains the shape and general organization of cellular contents; responsible for cellular movements.
Cytoskeleton
______ is a pair of centrioles plus pericentriolar material. The pericentriolar material contains tubulins, which are used for growth of the mitotic spindle and microtubule formation.
Centrosome
____ and _____ are the motile cell surface projections that contain 20 microtubules and a basal body.
Cilia and flagella
_____ move fluids over a cell’s surface.
Cilia
_____ move an entire cell.
Flagella
______ is composed of two subunits containing ribosomal RNA and proteins; may be free in cytosol or attached to rough ER. Protein synthesis.
Ribosome
_____ _____ (___) is a membranous network of flattened sacs or tubules.
Endoplasmic reticulum (ER)
_____ ____ is covered by ribosomes and is attached to the nuclear envelope. It synthesizes glycoproteins and phospholipids that are transferred to cellular organelles, inserted into the plasma membrane, or secreted during exocytosis.
Rough ER
_____ _____ lacks ribosomes. It synthesizes fatty acids and steroids; inactivates or detoxifies drugs; removes phosphate group from glucose-6-phosphate; and stores and releases calcium ions in muscle cells.
Smooth ER
_____ _____ consists of 3 - 20 flattened membraneous sacs called cisternae; structurally and functionally divided into entry (cis) face, medial cisternae, and exit (trans) face. Entry (cis) face accepts proteins from rough ER; medial cisternae form glycoproteins, glycolipids, and lipoproteins; exit (trans) face modifies the molecules further, then sorts and packages them for transport to their destinations.
Golgi apparatus
______ is a vesicle formed from Golgi complex; contains digestive enzymes. Fuses with and digests contents of endosomes, pinocytic vesicles, and phagosomes and transports final products of digestion into cytosol; digests worn-out organelles (autophagy), entire cells (autolysis), and extracellular materials.
Lysosome
_______ is a vesicle containing oxidases (oxidative enzymes) and catalase (decomposes hydrogen peroxide); new ones bud from preexisting ones. Oxidizes amino acids and fatty acids; detoxifies harmful substances, such as alcohol; produces hydrogen peroxide.
Peroxisome
_______ is a tiny barrel-shaped structure that contains proteases (proteolytic enzymes). Degrades unneeded, damaged, or faulty proteins by cutting them into small peptides.
Proteasome
_______ consists of an outer and an inner mitochondirla membrane, cristae and matrix; new mitochondria form from preexisting ones. Site of aerobic cellular respiration reactions that produce most of a cell’s ATP.
Mitochondrion
The ______ is to the cell as the human skeleton is to the body.
cytoskeleton
The cytoskeleton is made up of a number of different proteins that form thread- or tube-like structures. They are classified by size (smallest to largest), as ________, ________, _________.
microfilaments
intermediate filaments
microtubules
Microfilaments are made of the protein ______.
actin
________ are made of the protein actin.
Microfilaments
________ are involved with muscle contraction, cell division and cell locomotion.
Microfilaments
______ ______ are made from proteins such as keratin, vimentin, neurofilaments protein, lamins, and several others.
Intermediate filaments
_______ ______ help with mechanical stress and help attach cells to other cells or fibers.
Intermediate filaments
________ are made up of tubulin along with MAPs.
Microtubules
Microtubules are made up of _____ along with microtubule-associated proteins (MAPs).
tubulin
Microtubules are made up of tubulin along with _________ (____).
microtubule-associated proteins (MAPs)
_______ are 8nm in diameter and made of globular actin protein assembled into two strands.
Microfilaments
_______ are 25nm in diameter and is a hollow tube made of two different forms of tubulin protein.
Microtubules
______ are 10nm in diameter and many different proteins can make these.
Intermediate filaments
In cells that have an absorptive function, as in the intestin, a call can increase its surface area with little shaggy hairs, or _______.
microvilli
______-______ ______ are cell locations where microtubules are built, so they represent the origin of microtubules.
Microtubule-organizing center (MTOC)
In cell division (mitosis), centrosomes give rise to microtubules which in turn form the ____ ____ (____ _____), a rigid structure which lines up, and then divides chromosomes.
spindle apparatus (mitotic spindle)
In cell division (mitosis), centrosomes give rise to microtubules which in turn form the spindle apparatus (mitotic spindle), a rigid structure which lines up, and then divides _________.
chromosomes
_______ are the packed genetic material that must be evenly split between the two daughter cells.
Chromosomes
Centrosomes are comprised of _______ ______ and a _______.
pericentriolar material and centriole
______ are the “root” from which microtubule spirals grow.
Centrosomes
A _____ is a hair-like extension on the cell surface. It is usually on the inside of a tube-like structure and it moves material across the surface of the cell.
cilium (pl. cilia)
A _______ is a whip-like extension on the cell surface. In humans, it is only found on the sperm cell. It moves the cell through material.
flagellum (pl. flagella)
The most notable example of cilia in the human body is in the lower respiratory tract, where they drive something called the ______ _______.
mucociliary escalator
In a cilium, the motion is akin to rowing a boat: there is a _____ _____ as the cilium presents its full length and maximum resistance to the overlying material; and a _____ ______ as the cilium folds to present as little resistance as possible to the overlying material.
power stroke; return stroke
______ are the site of protein synthesis and it’s job is to make proteins.
Ribosomes
Ribosomes are a combination of a particular shape of RNA, called _______ ______ _____, plus proteins.
ribosomal ribonucleic acid (rRNA)
Ribosomes are found either as ____ ____ or associated with membranes to make up the _____ ______ ______
free ribosomes;
rough endoplasmic reticulum
_______ are made up of a large subunit (60S) and a small subunit (40S) which come together to form this completely.
Ribosomes
_____ _____ synthesize proteins in the cytosol.
Free ribosomes
The _______ is a collection of membrane bags with ribosomes arranged all along the outside.
RER (Rough endoplasmic reticulum)
Ribosomes use another type of RNA, called ______ ______ as the instruction sheet.
messenger RNA (mRNA)
Ribosomse use another type of RNA, called ______ ______ as the carrier for the raw materials of proteins (amino acids).
transfer RNA (tRNA)
What are the 2 types of endoplasmic reticulum?
Rough and smooth
The _____ is actually several different organelles with similar appearance, so that they cannot be distinguished in electron micrographs.
SER (smooth ER)
What are the functions of the smooth endoplasmic reticulum?
synthesis;
storage;
digestion
The _____ _____ receives unprocessed proteins from the rough ER and modifies them into their final form.
Golgi complex or Golgi apparatus
The ____ packages the proteins and “tags” them for export to their final destination.
Golgi
The Golgi is curved, and its functions are not distributed symmetrically. Rather, the _____ face or ___ face receives transported material from the RER while the _____ face or _____ face gives rise to secretory vesicles.
entry or cis;
exit or trans
The following are the steps in ______ _____:
- proteins are synthesized in the RER.
- Transport vesicles carry “raw”, unprocessed proteins to the Golgi.
- Transport vesicles fuse with the entry (cis) face of the Golgi.
- As proteins are processed, they are moved fro one Golgi stack to the next by transfer vesicles. In the Golgi stacks, the unused part of proteins are removed by one set of enzymes and, if a glycoprotein is being produced, the branched sugar groups are added here.
- The last transfer vesicle fuses with the exit (trans) face of the Golgi.
- The processed, completed protein is packaged into a vesicle and the vesicle is shed from the exit face of the Golgi.
protein processing
If the vesicle contains a ______ protein, it is packaged into a vesicle and released from the cell by exocytosis.
secretory
If the vesicle contains a _____ protein (or ______), it is packaged into a membrane vesicle which fuses with the cell membrane and becomes part of the cell surface.
membrane or glycoprotein
If the vesicle contains proteins which are ____ or ___ _____, then it is packaged into a vesicle which is directed to the lysosome for breakdown and recycling.
defective or not needed
_______ are the cell’s recycling bin.
Lysosomes
If cell components are malformed, or worn down by age, or no longer needed, they are packaged into a vesicle that fuses with a ______. There, the carbohydrates, lipids and proteins are broken into monomers and reused.
lysosome
_______ are formed at the Golgi complex. If the cell is sick or dying, the entire cell is dumped into the garbage can by releasing enzymes from this.
lysosomes
Lysosomes pH is about ____.
5.0
Enzymes (_____ _______) found in the lysosome are “tuned” to prefer the acid pH.
acid hydrolases
______ are named this because they make hydrogen peroxide.
Peroxisomes
Normally, hydrogen peroxide is kept sequestered in the peroxisome. If it escapes, it must be inactivated by the enzyme ______.
catalase
Peroxisomes are found in the ____ and _____, where they help carry out the detoxification functions of these organs.
liver and kidney
Peroxisomes are, also, used to break down fatty acids through a reaction called _____ _____.
beta oxidation
The beta oxidation is used to break down fats to obtain ______.
energy
Misfolded or malformed proteins are degraded in an organelle called the _______.
proteasome
A regular protein called ______ tags the proteins so the proteasome knows which is the offending protein.
ubiquitin
In the US, the Bureau of Engraving and Printing makes currency. In cells, the ____ makes ATP.
mitochondrion (pl. mitochondria)
_________ is the site of energy production for the cell and known as the ATP factories.
Mitochondria
Which cell types have large numbers of mitochondria?
- skin or muscle?
- bone or nerve?
- RBC or WBC?
muscle,
nerve,
WBC
______ have 2 phospholipid bilayers and their own DNA.
Mitochondria (ATP factories)
The inner membrane of mitochondria is extensively ____ to increase surface area.
folded
____ are pumped into the space between inner and outer membrans to “run” ATP synthesis.
Protons
What are the 2 components for the process of metabolism?
anabolism and catabolism
______ is the buildup of smaller molecules into large ones.
Anabolism
Energy is stored in bonds; this is ______.
endergonic
_____ reactions consume ATP and release waste energy as heat.
Anabolic
______ is the breakdown of large molecules into smaller ones.
Catabolism
Energy is released from bonds; this is _____.
exergonic
____ reactions create ATP and also release waste energy as heat.
Catabolic
______ reaction requires energy.
Endergonic
______ reaction releases energy.
Exergonic
Metabolism is a controlled burning process (_____ in chemical terms).
oxidation
_____ system absorbs nutrients from food.
Digestive
____ system brings O2 in, blows CO2 out.
Respiratory
______ system brings nutrients and O2 to cells, carries waste & CO2 away.
Circulatory
______ system rids the body of waste.
Excretory
The starting material for cellular energy production is ______.
glucose
The ultimate product of catabolism is ____, the energy currecny of the cell.
ATP
_______ is a three-carbon molecule that is an important intermediate in metabolism.
Pyruvic acid or Pyruvate
______ also has three carbons, but represents a metabolic “dead end”.
Lactic acid or Lactate
A molecule called ______ is like a “bucket” or “shovel” for two-carbon molecules.
coenzyme A (CoA)
The 2 carbon molecule that is carried by CoA is an ______ group.
acetyl
When CoA is carrying an acetyl group, it is called _______.
acetyl-CoA
Protons produced by the ____ _____ are carried by FADH and NAD+.
Krebs cycle
Protons produced by the Krebs cycle are carried by ____ and ____.
FADH and NAD+
There are alos electron “buckets” which are part of the _____ _____ _____ of mitochondria.
electron transport chain
Two major players in metabolism are ____ and _____.
pyruvic acid (pyruvate) and lactic acid (lactate)
______ is a sulfur-containing molecule that acts as a carbon carrier. Think of this a “shovel” that can only hold 2 carbon “lumps of coal”.
Coenzyme A (CoA)
Only 2 carbon units can fit into the _____ ____ “furnace”.
Krebs cycle
These 2 cofactors are not consumed in metabolic reactions. Rather, they serve as “hydrogen buckets” carrying hydrogen atoms (H) to where they are needed.
Flavin adenine dinucleotide (FAD) and
Nicotinamide adenine dinucleotide (NAD+)
Cells of the human body generally prefer ____ as a carbon source.
glucose
The energy between carbon atoms in glucose is converted into high-energy ______ ______ of ATP.
phosphate bonds
If oxygen is absent or in short supply, then cellular respiration is _______.
anaerobic
Anaerobic metabolism of glucose is called ______.
glycolysis
Glycolysis occurs in the _____ and does not need mitochondria.
cytoplasm
In glycolysis, one glucose molecule is converted into 2 molecules of _____.
pyruvic acid (pyruvate)
If oxygen is plentiful, then ____ respiration can take place.
aerobic
Aerobic respiration yields _____ net ATP molecules per glucose molecule.
36-38
______ O2: anaerobic pathway only, lactic acid is formed as a by-product.
without
____ O2: pyruvic acid (3 carbons) is tranferred to the mitochondrion for further processing.
with
If oxygen is present, then the _____ is fed into the aerobic respiratory pathway.
pyruvate (with 3 carbons)
If oxygen is absent, then pyruvate is converted to ____, a metabolic dead end.
lactic acid
When lactic acid builds us as a results of anaerobic metabolism, the cell becomes more acidic and the cell’s metabolism is rendered even less effective, a condition called ____ _____.
lactic acidosis
_____ buildup can interfere with muscle strenght during exercise.
lactic acid
If oxygen is absent, then the hexose (6-carbon) glucose is converted to ___ lactates and ___ carbons each.
2 lactates;
3 carbons
If oxygen is present, then the hexose (6-carbon) glucose is converted to __ pyruvates and ___ carbons each.
2 pyruvates;
3 carbons
_____ has 3 carbons.
Pyruvate
The steps in aerobic metabolism can only utilize 2 carbon units which, like lumps of coal, are “shoveled” into the pathway using a carrier called _____. The coal is consumed, the shovel is not.
coenzyme A (CoA)
The combination of a 2 carbon acetyl group and the coenzyme A “shovel” is called ______ or ____ for short.
acetyl-coenzyme A or acetyl-CoA
Before entering the Krebs cycle, _____ loses one carbon in the form of CO2. The resulting 2 carbon molecule is attached to a carrier, making acetyl CoA.
pyruvic acid
As the two-carbon molecule enters the Krebs cycle, the ____ is lost and a 6 carbon molecule is formed.
CoA
During the Krebs cycle, the 2 carbons are lost as CO2 and the equivalent of one ATP is formed from ____ and ____. Also, hydrogens are transferred to 3 molecules of NAD+ and one molecule of FAD, making 3 NADHs and one FADH2.
ADP and phosphate
The 2 carbon acetate units are fed into the ____ ____, also called the _____ _____ ____ or ____ ____ (___).
Krebs cycle;
citric acid cycle;
tricarboxylic acid (TCA)
As the name implies, the Krebs cycle operates in a ______ fashion, adding and subtracting carbons and giving off electrons as a side-product.
circular
The electrons in the Krebs cycle are carried by cofactors called FADH2 and NADH so they may be used in the ____ _____ _____.
electron transport chain
In the Krebs cycle and in the electron transport chain, _____ such as NAD+ and FAD are used to shift electrons around.
cofactors
Oxygen is the ____ and _____ acceptor at the end ogf the electron transport chain.
proton and electron
During cellular respiration, ______ (doesn’t use oxygen) gives 2 net ATP.
Glycolysis
During cellular respiration, _____ is fed into the system.
glucose
During cellular respiration, one glucose molecule makes two ____ _____ (carried by CoA) and 2CO2.
acetyl groups
During cellular respiration, acetyle-CoA feeds _____ _____ and makes CO2 ad cofactors.
Krebs cycle
During cellular respiration, _______ feed electron transport chain, “wheel” driven by H- “stream” water and APT produced.
cofactors
______ energy is stored energy, like a coiled spring of the energy between bonds in gunpowder.
Potential
______ energy is moving energy, like the jack-in-the-box that pops up or the bullet moving towards a target.
Kinetic
Excess glucose that is not needed for cellular metabolism is converted to glycogen and stored in the _____ and ______.
liver and muscle
If glucose in blood exceeds metabolic needs, then glucose is stored in a readily-available form called _____.
glycogen
Breakdown of proteins in skeletal muscles and other tissues releases large amounts of amino acids, The 2 carbon backbone of these amino acids can be used for production of glucose, although this is a highly inefficient process. The process is called _____ and occurs in the liver.
gluconeogenesis (“making new glucose”)
Some amino acid 2 carbon backbones can be fed directly into the Krebs cycle. This leaves the amino group, which ends up as ____, a major component of urine.
urea
Some amino acids (called _____ _____ _____) cannot be made in any case and must be part of the human diet.
essential amino acids
_______ are glycerol + 3 fatty acid chains.
Triglycerides
_____ ____ is a chain of carbons.
fatty acid
In the disease called _____ _____, the cells cannot metabolize glucose. Instead they turn to fat stores as an energy source.
diabetes mellitus
Fat (lipid) is metabolized by beta oxidation. This produces ____ as a by-product so ____ is a sign of uncontrolled diabetes mellitus.
ketones;
ketosis
What are the 3 types of ketones?
bets-hydroxybuteric acid;
acetoacetic acid;
acetone
What are the functions of the centrosome in the cell?
organizing microtubules;
forms a mitotic spindle;
forms cilia and flagella
What are the functions of the cilium in the cell?
moves fluids along the cell’s surface
What are the functions of the cytoskeleton in the cell?
provides intracellular framework
What are the functions of the cytosol in the cell?
transport of dissolved substances;
provides intracellular environment
What are the functions of the Golgi complex in the cell?
modifies chemicals received from the RER;
forms secretory vesicles;
forms lysosomes and peroxisomes
What are the functions of the lysosomes in the cell?
digests substances
What are the functions of the nucleus in the cell?
protects gene (DNA); copies information from gene to RNA
What are the functions of the mitochondrion in the cell?
generate ATP
What are the functions of the peroxisome in the cell?
synthesizes polypeptides
What are the functions of the plasma membrane in the cell?
used to identify cells; provides means for enzymatic reactions; regulates transportation of molecules; carries impulses for communication; forms cell junctions
What are the functions of the ribosome in the cell?
synthesizes polypeptides
What are the functions of the rough ER in the cell?
binds up ribosomes;
synthesizes phospholipids for membranes
What are the functions of the secretory vesicle in the cell?
discharges proteins via exocytosis
What are the functions of the smooth ER in the cell?
synthesizes fats and steroids
What chemicals are transported through diffusion through bilayer?
oxygen;
carbon dioxide;
steroid hormone
What chemicals are transported through diffusion through pores / channels?
potassuim ion;
sodium ion
What chemicals are transported through facilitated diffusion?
glucose
What chemicals are transported through osmosis?
water
What chemicals are transported through primary active transport?
potassium ion;
sodium ion
What chemicals are transported through secondary active transport?
glucose;
amino acids
What chemicals are transported through endocytosis?
bacteria
What chemicals are transported through exocytosis?
digestive enzymes;
neurotransmitters
The electron transport chain occurs in what organelle?
mitochondrion
Linker proteins may join the plasma membrane to ________.
microtubules
The glucose concentration in blood and extracellular fluid is much higher than the glucose concentration inside the cell. Therefore, in order to move glucose into the cell, we need __________________________________.
protein carriers that mediate facilitated diffusion
In this process, protein carriers move a substance across the cell membrane down its concentration gradient and no energy source is needed.
facilitated diffusion
