Module 7 Wk 3 Flashcards
what is rigor mortis?
sustained muscle contraction after death caused by the absence of adequate ATP production
what is the motor unit?
myofibers innervated by a single axon
what kind of movement does small motor units?
fine movement
what kind of movement does large motor units produce?
generation of force
how would you examine muscle in vivo?
clinical pathology
- CK, ALT, AST count
- myoglobin
Electrophysiology
- electromyography - needle straight to muscle
- electroneougraphy - stimulate nerve to see what is going on eith the muscle
how would you examine muscle ex vivo?
Gross examination
- size
- texture
- colour
histological examination
what are the different responses muscles give in response to insults?
- hypertrophy
- atrophy
- degeneration and necrosis
- regeneration
- chronic myopathic change
why is it only a possibli;ity and not super commen for muscle to regenerate?
As muscles are post mitotic tissue so stable.
what happens to the size of the myofibers during atrophy of muscle?
reduced
What is the earliest stage of degeneration seen?
hypercontraction
what can be seen at hyaline degeneration?
homogenously eosinophillica fibres and loss of straitions
T/F you dont see mineralisation with acute necrossi of muscle
false see it with all necrosis
What is segmental degeneration and necrosis classified based upon?
- distribution and time line
what does regeneration of muscle depend on?
intact staellite cells and extent of damgae to basal lamina
If basal lamina is intact what happens?
- macrophages enter and remove debris
- satillite cells become myoblasts
- myoblasts fuse to form myotubes
- essentail structures reformed
- nuclei move to perfiferal position
= regeneration
what might you see with a vascular response in muscles?
Ischemia which is where blood flow is resricted or reduced
what are the potentail causes of ischemia?
- occlusion of large blood vessel
- external pressue on a muscle
- internal oressue on a muscle
- vasculitis - inflamation of the blood cells
what sensitive cells would you see during ischemia?
- myofibers
- satallite cells
- fibroblasts
What is the action of bacteria that causes inflammation in the muscle?
- penetrates wounds
- spread from adjacent site
- heamatogenous
what does nespora canium cause in muscle?
Causes cysts with bradyziotes in the tissue
What muscles does trichinella spiralis effect?
toungue, masticatory muscles, resp muscles and muscles of the eye
What types of injuries cause traumatic pathology of muscles?
- crushing injuries
- lacerations
- tearing or ruptures
What muscle is most likely to rupture?
diaphram
Name 4 congenital conditions that effect muscles
- x linked muscle dystrophy
- labrador centronuclear mypopathy
- hyperkalemic periodic paralysis
- euine polysaccharide storage myopathy
What is oxidative injury of muscle due too?
loss of antioxidant defense mechanism
what can toxins cause in muscles?
multifocal and monophasis/polyphasis necrosis
whats the basic structure of a tendon?
collegen bundles arranged around a central elongated collection of tenocytes and capilarries
Describe a tenocyte?
- longitudinal rows alongside the collagen fibrils
- respond to mechanical signals
- synthesize and degrade all of the collagenous and non collagenous matrix
- repair the tendon matrix
Describe the accute phase of injury in tendons?
- inflammation
- lasts for several days
- inflam cells and pro-inflam mediators and cytokines
Describe the subacute phase of injury in tendons?
- Proliferation
- 3-6 weeks post injury
- inflammatory cells replaced by fibroblast cells and small blood vessels
- fibroblast migrate into the tendon from two sites - sheath and epitenon
describe the chronix phase of injury in tendons
- more than 3 months post injury
- features like scar tissue, disorganised collagen fibrils, increased numbers of fibroblasts and enlarged endotenon
- months to years
what are three problems in tendon healing?
- no regeneration - fasicles stuck together and destroyed by scar tissue
- ruptures may occur at margins of normal scar tissue
- persistance of inflammatory cells in endotenon
Describe an SDFT injury
- usually mid-metacarpal region
- risk of injury increases with age and intensity of excersise
- often preceded by a period of microdamage
How does excersise accelarate the level of microdamage?
via
- mechanical overload
- hyperthermia
- hypoxia
Describe how there is mechanical overload in the SDFT
- SDFT converts both potential and kenetic energy into elastic energy
- reduces muscle energy expenditure so increases the efficiency of locomotion
- there is a low meachnical safety margin though meaning that high levels of force break the collagen fibrils and alter the microscopic stucture of the tendon
How can there be hyperthermia in the tendon?
- not all elastic energy is returned during recoil of the tendon
- some is lossed as heat as there innefficient dissipation of heat within the tendon core due to poor vascular supply
what are features of advanced microdamage in the SDFT?
- red core lesion
- no clinical signs
- no swelling
- visible on ultasound
- when looking histologically there is more type 3 collagen
Describe parasitic diseases of tendons?
Onchocerca spp
- adult worm in tendon, tendon sheath, CT of brisket or abdominal wall
- microfilariae migrate to skin, picked up by blood sucking parasite
- passed on
Describe degenerative diseases of tendons?
suspensory desmitis - is changes in proteoglycan decomposition
What limbs are more prone to being lamb in horses?
forelimb
When investigating lameness in horses what patient information should you gather?
- breed
- age
- sex
- duration of ownership
- prior to purchase examination?
- current management
When taking a horse history from client what should you be interested in?
- the owners description of lamness - how long and nature of onset
- Any external trauma
- Any localising signs
- Horses respons to therapy
- Any prevoius lameness
What are the natures of onset that can be seen in horse lameness?
- sudden onset - acute traumatic injuries which often improve with rest
- rapid onset - severe lameness, freuently with wound
- gradual onset - slowly progressive, low grade lameness
when your genrally inspecting horse for lamness what should you look for?
- posture
- asymmetry
- BCS
- foot and limb conformation
What would you do on a detailed examination of the limb?
- close inspection
- palpation - heat, swelling, pain and digital pulse strength
- maniculation - reduced range of movement
- compare L and R
When should you not do a gait analysis in a horse?
When a fracture is suspected
What is gait evaulation good for identifying?
bilateral lameness
What are the aims of a flexion test?
- To exacerbate mild lameness/ provoke lameness
- To localise teh lesion causing the lamness
What are the two techniques used when performing diagnostic local analgesia?
- perineural - nerve block
- intrasynovial - joint/tendon sheath/ bursa block
what are the 2 nerve blocks you can do?
- abaxial sesamoid nerve block
- palmar digital nerve block
when looking at the limb conformation in the horse what is ideal?
The foot should be positioned symmetrucally beneath the limb and the foot contact the ground close to level
What should we see in lateral view of the forelimbs?
- refrence line = perpendicular from tuberosity at midpoint of scapular spine all the way doen to the ground level with heel bulbs
when looking at forelimbs crainally what should toes be doing?
toes of feet point straight ahead - abnormal if out or in
What is carpal valgus in horses?
outward roataion of limbs
what can happen if the carpal valgus is severe?
altered loading of carpys so joint disease
Qhat is carpal varus?
- inwards roatation
What is the lateral vie of hindlimbs of horse?
Perpendicular from tubera ischium meets ground 7.5-10cm plantar to foot
What is sickle hocks?
Excessive angulation of the hock so horse stands under from hock distally
Whats is sickle hocks due too?
Probably due to overload of dorsal apsect of sistal hock joints
What is excessive staight behind in Horse limbs?
Reduced angulation of hock, increased angulation of stifle and fetlock
What is dorsopalmber foot imblanace in horses?
increasment of load on the heels, DDFT and the navicular bone
How should you go about managing dorsopalmer foot imbalance?
- remedial
- farrier
- aim is to have more upright foot conformation, straight hoof- pattern axis
What could a equine foot that is broken backwards be caused by?
A result of a long toe, low heel foot conformation
What could a equine foot that is broken forwards be caused by?
A result of increased heel height relative to dorsal wall or a reduction in pastern slope
What is increased heel height seen in broken forward feet associated with?
Recession of frog and reduction in shock absorbtion resulting in increased loading of pedal bone at impact
What in horses is the movement of the hindlimbs realative to trunk determined by?
hip joint
T/F horses hindlimbs are mainly for perpulsion
True
What does the sacro-iliac joint allow?
- it is first fuberous joint of hindlimb between the pelvis and vertrbrae column that allows trabsfer of forces from hindlimb onto vet colomn
what are the 4 compartments of the pelvis?
- ilium - most cranial
- ischium - most caudal
- pubis - more cranail than ischium
- acetabular bone - all bones meet here
T/F the pelvic symphsis becomes bones over time
true
describe the ilium of the pelvis
There is the wing and body
What orientation is the wing of ilium in the cat and dog?
vertically - tall and narrow
What orientation is the wing of ilium in the Horses and ruminants?
Horizonatally
What projections are there in horses and ruminants?
- medial projection - tuber sacrale
- lateral projection - tuber coxae
What is the name of the formen present in the ischium and what runs through this?
obturator foreman where the obturator nerve runs through
What is the feature of the ischium that is the muscle attachment for the reproductive organs?
The ischiatic arch
What is the tuber ischium and whats different about them in the cow?
They are arge round protrusions at the inferoposterior aspect of the ischium - in cows they are triangle shaped
What forms the cranial aspect of the pelvic floor?
Pubis
What forms the arch where the pre-pubic tendon attaches too? and what else attaches here?
- Pubis
- the rectus abdominis muscle
What is the shape of the acetabulum and what is it for?
- cup shaped and boundary for other bones
What are the 3 components of the acetabulum?
Lunate surface
- cresent shaped
- articular surface of hip joint
- covered in hyaline cartilage
acetabular notch
- ventral deficit
- filled by tranverse ligament
acetabular fossa
- central non-articular area (depression)
- attachment of ligament of head of femur
Name the centres of ossification in the pelvis
Main
- illium bone - fuse together to form two halves
- acetabular fuses before born and pelvis symphysis last
Secondary
- dorsal wings of illium
- tuber ischium
- ischiatic arch
Where and what type of joint is the sacro-iliac joint of the pelvis?
- sacrum - wing of the illium
- fibrous joint = fused
What is the function of the sacro-iliac joint?
Transmits forces from hindlimb during locomotion so not much movement
Whats the difference between dog and horse/cow sacrums?
Dogs have 3 fused sacral vert and horses/cows have 5 fused vert
Describe the sacrotuberous/sacrosiatic ligament in large species
- A broad fiberous sheet
- runs from sacrum and inserts on the ilium and ischium
- gaps for nerbes to pass through
- relaxes at parturition
Describe the sacrotuberous/sacrosiatic ligament in the dog
- Caudal edges remain fiberous whihc provides anchorage for sutures during mucle repair surgery