Module 7 Wk 2 Flashcards
what produces the matix in cartlidge?
chrondroblasts
what maintains matrix in cartilidge?
chrondrocytes
what does ECM consist of in cartilidge?
fibres for rigidty
ground substances for resiliencyw
what does the fibre depends on within cartilidge?
what type of cartilidge
what does avascular mean?
no blood supply
what are the 3 types of cartilidge
- hyaline
- fibrocartilidge
-elastic cartilidge
what is the most commen type of cartilidge?
hyaline
what does hyaline cartilidge form?
temp skeleton in embryo which is gradually replaced by bone (long bones)
what is hyaline cartilidge made from?
u- abundent ground substance plus a few type 2 collogen fibres
where would you find hyaline cartilidge in adults?
articulating surface of moveable joints, walls of resp passages , costal cartilidge
T/F hyaline cartilidge goes underboth appositional and interstitial growth
True
what is elasatic cartilidge characterised by?
The precence of abundanct elastic fibres and is quite cellular
Where other than the ear pinna is elastic cartilidge found?
epiglottis
What is Fibro-cartilidge distinguished by?
It’s high content and orderly arrangement of type 1 collagen fibers.
Where is Fibro-cartilage typically found?
Regions where tendons attach to bones, the invertrbral discs and the symphysis between certain bones.
T/F there is lots of ground substance in Fibro-cartilage?
False - Limited
How are the cells arranaged in Fibro cartilage?
Chondricytes and Chondroblasts arranged in colums between bundles of collagen fibres.
What 2 types of cartlidge have appositional growth?
- hyaline
- elastic
Describe appositional growth?
New cartilidge forms at the edges
- Fibroblasts differentiate to chondroblasts and synthesise artilidge ECM
- Chondrocytes maintain the ECM
Describe Intersitial growth?
Growth within existing cartilage
- Chondrocytes become reactivated to blast form
- Then undergo cellular division to form isogenous groups that produce additional ECM
What is the function of synovial fluid apart from nurtrition?
Lubrication - provides film on cartilidge seeping in via mechanical action. Once seeped in it can go into spongey bit where it will dampen the effect of imapction
What is a sign using synovail fluid that there is problem in or around the joint?
- cloudy fluid
- blood in it
In cartilage, what is the main cell type involved in the formation of the extracellular matrix?
Chondro blasts
In cartilage which type of growth gives rise to the formation of isogenous groups?
Intersitail growth
Which type of cartilage is present at articulating bony surfaces?
Hyaline
Where would you expect to find perichondrium and what is its functional role?
surface of cartilage
What is Bone?
Cells and fibres embedded in a hard unbending calcified matrix
What are 2 functions of bone
Rigid and hard support (cf. cartilage)
Protects vital organs
Contains the bone marrow (hematopoiesis) origens of blood cells
Reservoir for calcium, phosphate and other ions released when needed
Transforms forces of skeletal muscle contraction into bodily movements
Why is bone a dynamic tissue?
capable of remodelling and repairing itself
What type of bone forms outer wall?
compact bone
What type of bone stenthens bone internally?
trabecular
What is the diaphysis?
hollow cylinder consisting of compact bone
What is the metaphysis?
where Growth plate originates - border between epi and diaphysis
Whats the difference in fibers when comparing lamellar and woven bone?
Lamellar bone has specific orientation of collagen fibres and woven bone has a randome one.
T/F woven bone is replaved by lamellar bone
True
what is the function of an osteoblast?
To form the osteoid
What is the function of the osteocyte?
maintan the bony matrix
how do the osteocytes communicate with one another?
via specail cellular extentions called canaliculi
What is the function of osteoclasts?
enzymatic digestion of ECM
Where are osteoclasts located?
On the external and internal surfaces of bony surfaces
What do osteoprogenitors cells become?
Osteoblasts and produce osteoid
What does osteoprogenitors cells give rise too?
Outer and inner circumferentail lamellae of bone
Describe volkman and haversian canals
- volkman canals come in at right angles to the parallel surface to the bone
- from volksman canals there are internal perpendicular canal called haversian
where does haversain systems develop?
Around the central vanacls which run parallel to the long axis of the bone
Describe the features you see at the haversian system
Cement line (CL)
Lacuna (L)
Osteocyte
Osteo-pogenitor cell (OP)
Osteoblast (OS)
When you see things in middle whihc dont have cental canal histologically what will it be?
Remodelling bone
what bone is there no haversian systems in?
Spongy, Trabecular, Cancellous Bone
what does Spongy, Trabecular, Cancellous Bones consist of?
Consists of Bony spicules/trabeculae covered with endosteum
Where does intra-membranous ossification occur?
in restricted areas only and spoontanously
what does intra-membranous ossification form from?
directly from ostogenic CT
What does it intra-membranous ossification form?
the flat bones of skull, mandible and maxilla
What is the more common ossification?
endochondral ossicication
T/F endochondral ossification starts with cartilidge model that then is replaced by bone?
Trueeee
What is endochondral ossification responsible for?
Growth of long bones
Describe the stages of formation of primary centre of ossification
- Cartilidge will be growing all the time from outside (appositional growth) and swell from withing (intersitial growth)
- Pericondulum will become vascularised chnaging the cells osteoprogenitor cells that then go onto fom the periosteal collar
- At the centre there will be prolifercation of chondrocytes followed by their hyptrophy initaiating the primary ossidication centre in the middle of the shaft
- they secrete vascular endothelial growth factor that induces the sprouting of blood vessels
- then chondrocytes will die off
- the cells that come in this blood supply will disolove in matrix and replace with bone.
what is cacified cartilidge matrix replaced by?
osteoid produced by osteoblasts that come in the blood stream
How does growth of long bones continue?
Via endochondral ossifiction at the epiphyseal growth plate
Describe what happens at the formation of the growth plates, growth and closure of the growth plate
- initail blood vessels (periosteal collar) extends up and down the shaft (diaphysis) where the cartiage has been replaced by bone
- secondary ossicification site starts at one of the epiphysis
- This process starts at other epiphysis
- The Epiphysis growth plates over time close up to form the epiphysis line
With respect to cellular events taking place at the epiphyseal growth plate put the following terms in order (ANS)
- resting zone
- zone of prolificating chondrocytes away from the ossification front which increases the length of the cartlidge
- zone of hypertrophy
- zone of cell death ( osteoclasts do this as chasing them)
- zone of vascular invasion
What type of bones is radius ulna?
both long bones
Out of radius and ulna which is weigth bearing and which provides leverage?
Radius is weight bearing and ulna provides leverage
Where on ulna is the olecranon process?
Large projection proximal to articular surface
Where is the anconeal process located on the ulna?
Fits into olecanon fossa of humerus
What articular surface is the trochlear notch on?
Of elbow joint
What does the radius sit between?
between the medial and lateral coronoid processes of the ulna
what is the site of attachment of the collateral ligaments of carpus
Medial & lateral styloid processes palpable
how many sites of ossification do radius?
3
how many sites of ossification do ulna have?
4
What are the components of the elbow joint?
- Trochlea of humerus at sistal end – subchondral bone goes the way from cranial to caudal - felxibility
- Head of radius +
- Trochlear notch of ulna
T/F does elbow joint have all typical synovail joint features?
yes including all collateral ligaments
what gives elbow joint stability?
- Collateral ligaments – joint stability
- Anconeal process (ulna) - also stability - engaged within, olecranon / ulnar fossa (humerus)
What movement is the elbow joint limited too?
Flexion and extention
what are the conditions that combined caiuse elbow dysplasia?
Osteochondrosis
Ununited anconeal process
Fragmented medial coronoid process
Elbow incongruity
what is the osteochondosis the erosions of?
erosion of articular cartlidge and subcondral bone
what is the origin of the deltoideus muscle?
spine of the scapula
where does the deltoideus muscle insert?
- lateral aspect of humerus
- intrinsic muscle
where is the deltoidues muscle loacted?
caudallateral aspect of limb
what is the function of the deltoidues muscle?
crosses caudal to shoulder joint - shoulder flexor
wwhat is the origin point of the Teres Major muscle?
caudal border of scapula
what is the insertion point of Teres Major muscle?
medial humerus
What is the loaction of Teres Major muscle?
caudomedial aspect of limb
what is the function of the Teres Major muscle?
crosses caudal to the shoulder joint and is a shoulder flexor
how many heads does the triceps brachii muscle have?
4
where does the long head originate from?
The caudal border of the scapula
where is the other heads origin?
shaft of the humerus
where do all the heads of the trachi brachii muscle insert?
olecron process of the ulna
Functions of the triceps brachii muscle?
Crosses caudal to shoulder- Shoulder FLEXOR
Crosses caudal to elbow- Elbow EXTENSOR
where is the origin of the biceps Brachii muscle?
supraglenoid tubercle
what is the insert point of the biceps brachii muscle?
proximal radius intrinsic muscles
what are the functions of the biceps brachii muscle?
Crosses cranial to shoulder - Shoulder EXTENSOR
Crosses cranial to elbow - Elbow FLEXOR
nerve supply that supplies biceps brachii is?
the Musculocutaneous nerve
where is the tendon origin of the biceps brachii muscle?
Intertubular groove of humerus
what is the biceps brachii tendon held in by?
transverse liagments
Whats is the lacertus fibrosis in the horse?
Fiberous extention that inserts into metacarpal 3 and acts as a carpal extensor?