Module 1 Flashcards
Stimulus
part of negative feedback; it is the deviation from the set point
Receptor
part of negative feedback; detects the stimulus and sends input to control centre (via hormones/nerve impulse)
Control Centre
part of negative feedback; brain; evaluates input from receptor and generates output ( in form of hormone, nerve impulse)
Effector
part of negative feedback; body structure that receives outputs and produces response to counteract stimulus
Homeostasis
state of relative internal stability; function at optimal level
positive feedback
produces response that reinforces initial stimulus; shut off by event outside of system
Disorder
abnormality of structure/function
Disease
illness characterized by set of symptoms
symptoms
subjective changes in body function not apparent to observers
signs
objective changes that are observable and measured
aging
decline in body’s ability to restore homeostasis
chemical
atoms and mlcs found in cell (C, H, N, O)
Tissues
groups of cells similar in structure and function
organs
composed of different kinds of tissues
organ system
groups of organs working together for common function
Cytosol
1/3 component of cytoplasm; fluid containing solutes; site of chemical reactions
Cytoskeleton
1/3 component of cytoplasm; provides support and aids in movement; contains microtubules, microfilaments and intermediate filaments
Ribosomes
factory for protein synthesis; attached to rough endoplasmic reticulum (Rough ER)
Endoplasmic Reticulum
network of fluid filled channels running through cytoplasm
Rough ER
studded with ribosomes
synthesis and modification of proteins
Smooth ER
extending from rough ER
synthesis of lipids and detoxification of harmful substances
Golgi Complex
sorts mlcs from rough and smooth ER and sends them to destination
modifies the protein by adding carbs to lipids and proteins
proteins enter/exit in vesicles
Lysosomes
packets of digestive enzymes; breakdown and recycle old organelles
Mitochondria
Energy factory; cellular respiration: break down sugars to produce ATP
Proteasomes
disposals for cytosolic proteins that are no longer functional
Nucleus
control centre; contains all genetic info and directs synthesis of proteins
Chromosomes
found within nucleoplasm; strands of DNA combined with proteins
make up all genes (46 in all human somatic cells)
Nucleolus
contains DNA from several chromosomes that code for synthesis of ribosomes
ribosomes are shipped out via nuclear pore
Plasma membrane
selectively permeable membrane composed of proteins and lipids
Phospholipids
within membrane are arranged with hydrophobic tails facing in, and hydrophilic heads facing extracellular fluid
the hydrophobic tails prevent large charged mlcs from entering cell
cholestrol
lipid found in membrane with hydrophilic and hydrophobic portions
determines flexibility of membrane (more=more flexible)
Integral membrane proteins
sit in middle of membrane bilayer; contains hydrophobic portions
hydrophilic pores provides route for charged mlcs to enter/exit
Peripheral proteins
only found at one side of bilayer; many functions such as enzymes
Glycoproteins/glycolipids
chains of carbs attached to either proteins or lipids on extracellular layer that act as identify markers (allowing cells to recognize each other)
Intracellular fluid (ICF)
fluid contained inside body cells (about 2/3)
Extracellular fluid (ECF)
fluid outside of cell
Interstitial fluid
extracellular fluid (ECF) in microscopic spaces btw cells and tissues
Plasma
ECF in blood vessels
Lymph
ECF in lymphatic vessels
Solute
any material dissolved in a fluid
Solvent
the fluid in which the material is dissolved in
Solution
variety of solutes are dissolved in a given solvent
Concentration
amount of solute in a solution
Concentration gradient
difference in concentration btw two different areas (ICF and ECF)
Passive Transport
transport without expenditure of energy (moves down concentration gradient (high-low)
Simple Diffusion
form of passive transport; lipid soluble substances diffuse through lipid bilayer (O2, CO2, N, fatty acids, steroids, fat soluble vitamins)
Facilitated Diffusion
transport of mlcs by specific protein transporters in membrane
Channels: ions move through ion channels formed by proteins (some are gated)
Osmosis
facilitated diffusion of water down concentration gradient
osmotic pressure
solutions containing solute mlcs that cant pass through membrane exert pressure on membrane (higher the concentration of solute= higher the pressure )
Isotonic Solution
solution in which cells maintain their normal shape and volume (concentration of solutes is same on each side)
Hypotonic Solution
areas with less solute concentration (higher water concentration); causes swelling and busting of cells (hemolysis)
Hypertonic Solution
higher concentration of solutes (less water); water leaves cell faster than it enters; causes cell to shrink (crenation)
Active Transport
requires energy (ATP); goes against concentration gradiet and requires use of carrier proteins ie. Na/K pump
Endocytosis
materials move into cell in a vesicle formed from plasma membrane
Phagocytosis
form of endocytosis where large solid particles (bacteria, dead cells) are taken in by cell; ONLY occurs in phagocytes (WBC macrophages)
Bulk Phase Endocytosis
cells take up tiny droplets of ECF; membrane forms vesicle containing droplet and enters cytosol
lysosome engulfs solutes; resulting in smaller mlc
Exocytosis
materials move OUT of cell by fusion of vesicle formed inside cell with plasma membrane; carried out by secretory cells (goblet cells)