Module 0 Flashcards

(122 cards)

1
Q

During the history what symptoms would indicate radiculopathy? Select all that apply.

A. Muscle weakness in a peripheral nerve pattern
B. Parenthesis in a cutaneous pattern
C. Pain that is unrelieved by rest
D. Parenthesis in a dermatomal pattern

A

C and D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the significance of the endoceurium in the context of positive atonal repair>? Endometrium acts:

A. As a guide conduit for the sprouting axons
B. As a source of nerve growth factors
C. In creation of scar tissue

A

A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Define Wallerian Degeneration. Choose all that apply

A. A process at the distal stump of a damaged axon, preparing the way for axonal sprouting
B. A process organized by Schwann cells following a lesion of an axon
C. A process only occurring in CNS axonal damage
D. A process involving the breakdown of the proximal stump of a damaged axon

A

A, B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Define transneuronal degeneration

A

When one neuron is lost, the neuron ahead or behind in the synaptic chain may also be lost

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Define axonotmesis

A

Axonal disruption of some of the axons in a nerve, without displacement of the endoneurium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

The axon reaction refers to:

A. The process of degeneration occurring at the distal stump of the disrupted axon
B. The reaction of the axon to the loss of connection with its cell body
C. The total effect on the cell body due to the loss of its axon
D. Depersal of the nucleolus, only

A

C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Describe the process of chromatolysis. Choose TWO.

A. Displacement of the nucleus
B. Dispersal of the Nissl Substance
C. Dispersal of the rER
D. Dispersal of the nucleolus

A

B, C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Axonal sprouting of PNS axons occurs due to growth factors released from:

A. Oligodendrocytes
B. Mast cells
C. Schwann cells
D. Endothelial cells

A

C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is a neuroma? Choose all that apply.

A. Enlarged knot of axonal sprouts and scar tissue
B. Malignant tumor of neurons
C. Tissues created in a nerve affected by neurotmesis
D. Incomplete sprouting of axons unable to enter the endoneurial tube

A

A, C, D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Describe the process of recovery following axonal damage in the CNS. Choose the best single answer.

A. Wallerian regeneration
B. Neuronal mitosis
C. Axonal sprouting
D. Neuroplasticity

A

D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which one of these describes the Dermatome affected most by an L5-S1 disc herniation

A. L4
B. S1
C. L5

A

B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

The Achilles reflex would be lost in an __ nerve root lesion.

A. S1
B. L4
C. L5

A

A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Desires entrapment at the intervertebral disc by disc herniation, what other structure may be responsible for the pain syndrome called sciatica?

A. Entrapment by the gastrocnemius muscle
B. Entrapment by the piriformis muscle
C. Entrapment by the gluteus Maximus muscle

A

B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

There is an orthopedic test that is well-known to be specific to diagnosis of spinal root involvement and disc herniation. What is it:

A. Provacative test called Babinski’s test
B. Stretch test called Gaenslen’s Test
C. Tension test called the Straight Leg Raise (SLR)

A

C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

T or F
Disc herniation always require surgery to reduce them

A

F

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the four cardinal sings of inflammation ?

A

Pain, heat, swelling, redness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What helps to differentiate involvement of MSK damage versus NM system damage?

A

Pain progression
Pattern of pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Does lumbar sprain strain while causing soft tissue damage typically affect spinal nerves?

A

No

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is a common cause of Spinal nerve injury?

A

Intervertebral disk injury

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Symptoms of spinal nerve entrapment:

A

Pain not affected by rest
Pain progression
Pain pattern includes areas not directly impacted by mechanism of injury

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Signs of spinal nerve entrapment:

A

Antalgic posture
Weakness
Reflex changes
Sensory changes
Positive orthopaedic testing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What is shooting pain called?

A

Radicular pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What is radiculopathy?

A

Injury or irritation of a nerve with pain that radiates from the injured area in a recongnizable pattern

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What was the type of onset for Mrs. Cornwell?

A

Acute, stopped her from finishing her job

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
What are some sprain/strain findings?
Pain on movement, rest relieves pain Pain only in area of injury No radiating pain Improves with time
26
Is pain subjective or objective?
Subjective
27
What contributes to and complicates both the presentation and the healing of physical trauma?
Emotional trauma and stress
28
What makes up the CNS? What makes up the PNS?
Brain and spinal cord Cranial and spinal nerves
29
How many spinal nerves are there and where do they originate?
31, spinal cord, part of PNS
30
Composition of peripheral nerves
Sensory, motor, autonomic fibers
31
Radic/o, radicul/o, rhiz/o
Nerve root
32
Path/o
Disease
33
Myel/o
Spinal cord
34
Encephal/o
Brain
35
Praxi/o
Action or movement
36
Cept/o
To receive or detect
37
Noci-
To harm or injure
38
-tmesis
To cut
39
-paresis
Weakness
40
What is the first thing to relieve a stimulus?
Primary Afferent axon’s receptor
41
What are some of the least specific receptive end organs?
Receptors for tissue damage typically affect
42
What type of receptor receives all types of damaging stimuli?
Polymodal C-fiber free nerve ending
43
What does the receptor on the primary afferent axon receive?
Stimulus
44
Where does perception occur?
Cortex of cerebrum
45
Define receptive fields
Area innervated by C-fiber axon further refined at level of cord and cortex
46
What are bundles of axons in the periphery?
Nerves
47
What are bundles in the CNS?
Tracts
48
Axons of C-fibers are myelinated or unmyelinated?
Unmyelinated
49
The areas that have smaller receptive fields do what?
Project more strongly to the cerebral cortex
50
T or F Pain localization is more accurate in the face than low back
T
51
Does nervous tissue itself exhibit receptive field patterns?
No
52
Spinal nerve irritation results in what type of pain pattern?
Dermatomal
53
Peripheral nerve irritation results in what type of pain pattern?
Cutaneous
54
Does irritation of the CNS result in conscious awareness? Why?
No, there are no sensory receptors on the brain
55
What are the receptive fields of the spinal nerve afferent axons?
Dermatomes
56
In what dermatome was Mrs. Cornwell having pain?
S1
57
What direction to lumbar discs typically herniate?
Dorsolaterally
58
What disc was affected with Mrs, Cornwell?
L5-S1 S1 NR affected
59
Where did Mrs. Cornwell describe her pain to be?
Shooting down her leg pain in lateral calf, lateral foot, little toe
60
How is the integrity of the spinal nerves evaluated?
MSRs
61
L4 muscle indicator
Tibialis anterior
62
L4 reflex indicator
Patellar
63
Medial leg, foot, great toe, anterior knee
L4 dermatome pattern
64
L5 muscle indicator
Extensor hallicus longus
65
L5 reflex indicator
Medial hamstring
66
L5 Dermatome pattern
Dorsum of the foot, heel
67
S1 muscle indicator
Fibularis longus/brevis
68
S1 reflex indicator
Achilles
69
S1 dermatome pattern
Lateral leg, foot, little toe
70
What nerve root is affected if the patient cannot extend their big toe?
L5
71
What nerve root is affected if the patient cannot do eversion?
S1
72
Surrounds all the fascicles of the nerve
Epineurium
73
Surrounds each nerve fasicle
Perineurium
74
Surrounds individual axons
Endoneurium
75
What is the majority of endoneurium made of?
Non-living product of fibroblasts (matrix)
76
What type of connective tissue is endoneurium?
Loose connective tissue
77
What type of connective tissue is Epineurium and Perineurium?
Dense irregular
78
What is the part of the axon that always degenerates if a nerve is severely damaged?
Part distal to the injury
79
Process of nerve repair.
Proximal stump sprouts into the uninterrupted endoneurial tube
80
PNS or CNS Always has connective tissue investments What are connective tissue investments important?
PNS Provides nutrients blood supply, waste transport ion to axon protects axon.
81
How can lesions occur?
As compressions or entrapments
82
If the axon is disrupted in the PNS…
The distal stump degenerates
83
If there is damage to the axon in the CNS….
The neuron will likely die
84
Explain retrograde transeuronal degeneration
Neuron before the lesion might undergo degeneration
85
Explain orthography transneuronal degeneration
Neuron after the lesion might also undergo degeneration
86
What is neuronal irritation or damage from compression, mild injury, resulting in a non-severed axon?
Neuropraxia
87
What is said about recovery for neuropraxia?
Full recovery can be achieved
88
What is moderate to severe compression, where the distal stump begins to undergo Wallarian degeneration but the endoneurium is not displaced?
Axonotmesis
89
What is said about recovery for Axonotmesis?
Regeneration of proximal stump can occur 1-2 mm per day
90
What is transection of an axon where the whole nerve is severed and the 2 ends of the endoneurium are displaced so the axon sprouts cannot find their way back?
Neurotmesis
91
What is said about the recovery for neurotemesis?
Surgery might be required, won’t heal on its own
92
What can cause a neuroma?
Neurotemesis
93
What is the axon reaction?
Reaction of the cell body to the loss of its axon
94
What is a complex ball of axon sprouts a scar tissue on a damage nerve axon?
Neuroma
95
What nerve is irritated in Morton’s neuroma? Where is the nerve irritated?
Medial plantar nerve Between 3rd and 4th toes
96
Important features of the axon reaction
Chromatolysis Neuronal cell body swelling displacement of nucleus Dispersal of nucleolus
97
What is the first thing that happens after an axon is damaged?
Swelling of the proximal and distal stumps
98
What is the axon reaction also called?
Retrograde reaction
99
T or F Neurons recover in the PNS
T
100
T or F Neurons will die in the CNS
T Likely die
101
What causes swelling of the cell body?
Dispersal of ribonucleic acid acid attracts water into cell body swelling displacement
102
What directs the recovery of axonal sprouts?
Endoneurial tube
103
Define hypoxia
Deficiency of oxygen in the tissues
104
Damage to axons in the CNS can occur by
Hypoxia from stroke or TBI
105
What do fMRIs show?
Level of brain engagement or activity
106
During history, what symptoms would indicate radiculopathy?
Pain unrelieved by rest parenthesis in dermatomal pattern
107
What organizes wallerian degeneration?
Schwann cells
108
Define transneuronal degeneration
When one neuron is lost, the neuron ahead or behind in the synaptic chain may also be lost
109
What is axonal disruption of some of the axons in a nerve without displacement of the endoneurium?
Axonotmesis
110
Describe the process of chromatolysis
Dispersal of the Nissl substance dispersal of the rER
111
What type of nerve entrapment involves cutaneous patterns of sensory loss?
Peripheral
112
What type of nerve entrapment involves more muscles being affected?
Peripheral
113
What type of nerve entrapment involves motor loss linked to nerve and muscles innervated by nerve?
Peripheral
114
What segments are more vulnerable to spinal nerve entrapments?
After L2 when the spinal cord ends
115
Where is the nucleus found during swelling in the cell body of the axon reaction ?
Periphery
116
Why is there dispersal of the nucleolus of the cell during the axon reaction?
Ribosomal RNA is made by the nucleolus and it is no longer needed
117
How is learning and memory constantly happening in the brain?
Neuronal plasticity
118
Ways to make sure that nerve recovery is effective?
Brain getting all nutrients
119
Describe the process of recovery following axonal damage in the CNS
Neuroplasticity
120
Neuroapraxia
(Irritation) = peripheral nerve gets “dinged”
121
Axonotmesis
(moderate to severe compression) = gets interruption, can recover by 2mm a day, endoneural tube is fine
122
Neurotemsis
(Transection) = real problem - (can only be reconnected though possible surgery) injury/degeneration/neuroma formation (Endoneuronal tubes do not line up anymore - neuroma forms)