Modern infectious diseases II Flashcards
Role of ACE (angiotensin converting enzyme)?
Converts AngI into AngII
Role of ACE2?
Concerts AngII into Ang 1-7
What can Ang1-7 do?
Bind to Mas GPCR
What can the Ang 1-7 interaction with Mas cause?
Vasodilation
Effect of SARS-CoV-2 binding to ACE2?
Overactivation of the renin angiotensin system
Why does covid infection often begin in the nose/throat?
Most common most of transmission is inhalation
Where was ebola first discovered?
Near the ebola river
Effect of covid on cells lining blood vessels?
Promotes thrombosis (clotting) and leads to cardiac inflammation/heart attack
Why did ebola initially spread rapidly?
Traditional burial practises that involved touching the body with bare hands
Effect of renin angiotensin system overactivation?
Increased lung damage, oedema
Result of covid infection lungs?
Destruction of alveoli–> less O2 absorbed per breath
Where does a covid infection go after the nose/throat if not dealt with?
Respiratory tract and lungs
Cause of ebola?
Ebola virus
What type of virus is ebola virus?
filamentous virus in the Filoviridae family
Ebola transmission?
fruit bats (blood), human-human (blood and other bodily fluids)
Ebola incubation?
2-21 days
Initial ebola symptoms?
Fever, fatigue, muscle pain, headache, sore throat
Latter ebola symptoms?
V high fever, bloody vomiting & diarrhoea, internal bleeding, seizures, loss of consciousness death
What organs can the latter ebola symptoms affect?
Impaired kidney/liver function, brain damage
Supportive care ebola treatment?
Hydrated
Monoclonal antibodies used to treat ebola?
Inmazeb, ebanga
How do the monoclonal antibody treatments for covid work?
Bind to glycoprotein spikes on the viral surface, preventing it from enterins host cells
Why are the ebola vaccines not distributed much?
Ebola is v rare, and cost benefit analysis said no
How is ebola vaccination usually done?
Focused ring vaccines are done instead vaccinate people who know the infected
