MOD1 - Biological Foundations of BHD Flashcards
What is the frontal and prefrontal cortex’s purpose
abstract thought, planning and decision making
higher cerebral functions
what happens to the size of the hippocampus in depression
smaller
what happens to the activity in the amygdala in depression
higher activity
what does amygdala do
recalls and responds to traumatic events
what 3 things does the hypothalamus do
regulates motivated behaviour
triggers stress response
controls pituitary gland
what mental illness is the thalamus associated with
bipolar disorder
what is the stress response system
Hypothalamus -CRH-> pituitary -ACTH-> adrenal gland -cortisol-> immune system
serotonin increases/decreases with depression and suicide
decreases
dopamine is associated with which two illnesses
substance abuse and psychosis
Norepinephrine is related with which two conditions
stress
triggers anxiety
what does acetylcholine do
memory and recall
what condition is glutamate associated with and is it excitatory or inhibitory
associated with BPD and lithium impact
excitatory
is GABA inhibitory or excitatory and what effect does it have on anxiety
inhibitory
reduces anxiety
which 2 neurotransmitters are altered by decreased eostrogen
serotonin and norepinephrine
experience have what effect on brain development
develops neuronal connections
toxic stress has what effect on the stress system
prolonged activation of the stress system
prolonged toxic stress has what effect on cortisol levels and neural systems
prolonged cortisol elevation
less neural connections
what are the 2 stress hormones
adrenaline
cortisol
what 2 things does adrenaline do in stress
mobilise energy store and alter blood flow
what 2 things does cortisol do in stress
mobilise energy store and inhibit immune system
sustained cortisol damages which part of the brain
hippocampus
what are the two branches of the nervous sytem
CNS and PNS
what are the 2 branches of the PNS
somatic and autonomic
what are the 2 branches of the ANS
sympathetic and parasympathetic
what neurotransmitter is associated with sleep, aggression, eating, sexual behaviours and mood
serotonin
what neurotransmitter is in control of reward and pleasure
dopamine
circadian rhythms are disrupted by which 3 factors
increased level of stress hormone cortisol
decreased level of eostrogen (alters NE and Epinephrine) and testosterone (after 50yo)
what is the order of the 3 catergories of brain development
language, sensory and higher cognition
sensory pathway first
language
higher cognition function last
what are the differences in the effects of occassional inattention and chronic under-stimulation
occasional = growth promoting in supportive environments
understim = developmental delays
what is the difference between severe neglect in family context and institutional setting
family = absence of 1 on 1 interaction, fail to provide basic needs
institutional = many children and few caregivers and no individuallised adult-child relationship
What are teratogens
chemicals or factors that damage fetus development
what happens if the tertogen timing or dose is less than threshold
some exposure results in small risk of causing malformation
what is FASD
permanent birth defect with maternal alcohol use during pregnancy
what does Chronic high cortisol levels do to the nervous system
in this case is the stress threshold high or low
overactivation of the nervous system
low threshold
what trimester is the most important period of time for organ development
1st trimester
first 3 months
what are the 3 symptoms of Fetal Alcohol spectrum disorder
growth deficiency
facial abnormalities
organic brain damage
what are the sentinel facial features of FASD
nose and upper lip
what effects does brain development and stress have on the brain and cognitive
impairs learning
reduce hippocampus growth and impacts memory
What is sensation
Detection of physical energy by sense organ that sends info to brain
what is the stimuli and the sense organ/receptor of sight
stimuli = light
sense organ/receptor = eyes