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Pharm Exams > Mod 9- Drugs affecting GI Secretions > Flashcards

Mod 9- Drugs affecting GI Secretions Flashcards

1
Q

Why can NSAIDs cause peptic ulcer disease?

A

they decrease the protective prostaglandins

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2
Q

These drugs block the release of hydrochloric acid in response to gastrin

A

Histamine- 2 (H2) antagonists

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3
Q

These drugs interact with acids at the chemical level to neutralize them

A

Antacids

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4
Q

These drugs suppress the secretion of hydrochloric acid in the lumen of the stomach

A

Proton Pump Inhibitors

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5
Q

These drugs coat any injured area in the stomach to prevent further injury from acid

A

GI Protectants

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6
Q

These drugs inhibit the secretion of gastrin and increase the secretion of mucous lining of the stomach providing a buffer

A

Prostaglandins

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7
Q

These H2 antagonists are approved for use in children (-idine)

A

famotidine

ranitidine

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8
Q

This PPI is successful in decreasing ulcer formation r/t drugs/ stress in children

A

Lansoprazole

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9
Q

This drug is an abortifacient and will cause abortion of a fetus

A

misoprostol

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10
Q

What is the best gastrointestinal drug class for older adults

A

Proton pump inhibitors

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11
Q

These types of drugs end in “-tidine”

A

Histamine -2 (H2) antagonists
cimetidine
ranitidine
famotidine

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12
Q

These are used for Treatment of pathological hypersecretory conditions such as Zollinger–Ellison syndrome

A

H2 Antagonists

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13
Q

T/F there are so many drug interactions with H2 Antagonists a drug guide should be consulted

A

TRUE

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14
Q

At what time of day would we give H2 Antagonists

A

Administer oral drug with or before meals and at bedtime

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15
Q

H2 Antagonists Prototype

A

Cimetidine

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16
Q

These inorganic chemicals neutralize stomach acid by direct chemical reaction

A

Antacids

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17
Q

These drugs end in “-carbonate”

A

Antacids
sodium bicarbonate
calcium bicarbonate

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18
Q

Name two antacid salts

A

Magnesium Salts

Aluminium salts

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19
Q

What is an ADE of antacids

A

Rebound acidity- stomach becomes alkaline then releases more acid

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20
Q

When would you take antacids in relation to other drugs and why?

A

It affects the absorption of many other drugs so it should be taken 1 hour before or 2 hours after other drugs

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21
Q

T/F Antacids should be swallowed whole without chewing or crushing

A

FALSE Chew tablets thoroughly and follow with water

22
Q

T/F Antacids can cause diarrhea and patients should be monitored for electrolyte imbalances

A

TRUE

23
Q

Antacid Prototype

A

sodium bicarbonate

24
Q

These drugs Act at specific secretory surface receptors to prevent the final step of acid production and thereby decrease the level of acid in the stomach

A

Proton Pump Inhibitors

25
Q

PPI End in what suffix

A 
“prazole”
Omeprazole 
Esomeprazole
Lansoprazole
Pantoprazole
Rabeprazole
26
Q

When are PPIs indicated?

A

Short-term treatment of active duodenal ulcers, GERD, erosive esophagitis, and benign active gastric disease
Long-term treatment of pathological hypersecretory conditions

27
Q

PPI can cause adverse effect on this system in the body

A

Upper respiratory tract- cough stuffy nose, hoarseness, epistaxis

28
Q

ADE of PPIs

A

CNS- HA dizziness, vertigo, insomnia apathy

GI- D, ab pain, tongue atrophy

29
Q

Drug/ drug interactions of PPIs

A

Benzodiazepines, phenytoin, warfarin- Increase toxicity of these meds
Ketoconazole, theophylline- Decreased levels of these medications
Sucralfate- PPIs not absorbed well
Clopidogrel- Increase CV effect

30
Q

T/F PPIs should be chewed thoroughly when they are administered before meals

A

FALSE- swallowed whole

31
Q

We should check these systems as we know they are affected by PPIs

A

Neurological- orientation, affect, reflexes

Respiratory status- rate/ rhythm

32
Q

PPI prototype

A

Omeprazole

33
Q

This drug is indicated for Ulcer healing because it protects site against acid, pepsin, and bile salts

A

GI protectant- Sucralfate

34
Q

This is a potential build up that can lead to renal failure caused by GI protectants

A

Aluminum build up

35
Q

Drug/ drug interactions of GI protectants

A

Aluminum salts

Phenytoin, fluoroquinolone, or penicillamine

36
Q

When would we administer GI protectants during the day?

A

Administer the drug on an empty stomach 1 hour before or 2 hours after meals and at bedtime

37
Q

We shouldn’t give antibiotics or antacids within ___ min. of a sucralfate dose

A

30 min.

38
Q

This is a prostaglandin used to prevent NASAID induced gastric ulcers and for tx of duodenal ulcers

A

Misoprostol

39
Q

These drugs work by inhibits gastric acid secretion and increases bicarbonate and mucous production in the stomach

A

Prostaglandins- misoprostol

40
Q

This drug causes “lady problems” + GI effects

A

Prostaglandins- Misoprostol

41
Q

We absolutely CANNOT give this drug to someone that is pregnant; we should arrange for serum pregnancy test on 3rd day of cycle

A

Prostaglandin- misoprostol

42
Q

What is the digestive enzyme pancrelipase used for?

A

Cystic fibrosis

43
Q

How does the digestive enzyme pancrelipase work?

A

Pancreatic enzymes are replacement enzymes that help the digestion and absorption of fats, proteins, and carbohydrates

44
Q

How does the digestive enzyme saliva substitute work?

A

Contains electrolytes and carboxymethylcellulose to act as a thickening agent in dry mouth conditions

45
Q

Why would we caution someone with CHF when taking a saliva substitue?

A

it can lead to abnormal absorption of electrolytes

46
Q

These electrolytes can increase as an ADE of saliva substitutes

A

magnesium, sodium, potassium

47
Q

Pancreatic enzymes can cause these ADE

A

GI irritation, nausea, abdominal cramps, and diarrhea

48
Q

These digestive enzymes can be given PRN

A

saliva substitutes

49
Q

These digestive enzymes should be given with meals and snacks

A

Pancreatic enzymes

50
Q

Digestive enzyme prototype

A

Pancrelipase

Pharm Exams (25 decks)

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