Mod 6- Antianginal Agents Flashcards

1
Q

What type of angina subsides w/ rest and causes no damage to the heart?

A

Stable angina

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2
Q

What type of angina occurs with episodes of ischemia even at rest?

A

Unstable Angina

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3
Q

What type of angina is caused by the SPASMING not just narrowing of the vessels?

A

Prinzmeta’ls angina

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4
Q

What is the action of Antianginal Drugs

A

improve blood delivery to the heart by dilating the blood vessels- thus increasing supply of o2
improve blood delivery to heart muscle by decreasing work of the heart- decreases demand for o2

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5
Q

T/F Antianginal Drugs do not cross the placenta and enter breastmilk

A

FALSE- they do cross placenta and enter breast milk

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6
Q

How would you identify a Nitrate medication?

A

Has nitrate or Nitro in the name
isosorbide dinitrate
isosorbide mononitrate
Nitroglycerin- taken when chest pain

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7
Q

Action of Nitrates

A

Acts on smooth muscle to cause relaxation and depress muscle tone of blood vessels

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8
Q

When are nitrates indicated?

A

prevention & tx of attacks of angina pectoris

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9
Q

Contraindications of Nitrates

A

allergy, severe anemia- reduced o2 carrying capacity, vasodilation can cause hypotension, can complicate o2 delivery
head trauma/ cerebral hemorrhage- can cause more bleeding

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10
Q

Cautions for Nitrates

A

hepatic/ renal disease

hypotension, hypovolemia, conditions that limit cardiac output

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11
Q

Nitrate ADE

A

R/t vasodilation and decrease in blood flow
CNS- HA, dizziness, weakness
GI- N/V
*Hypotension- especially when changing positions
flushing, pallor, increase perspiration

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12
Q

Drug/ Drug interactions for Nitrates

A

Ergot derivatives- can cause vasoconstriction, causes decreased effects
Heparin
Sildenail, tadalafil, vardenafil- erectile dysfunction drugs

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13
Q

What is an important question to ask male patients if planning to administer a nitrate? Can impact life/ death

A

Have you taken any erectile dysfunction drugs in the last 24 hours? If given together, can cause CV collapse

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14
Q

Should a pt lay down or stand up prior to administering Nitrates?

A

Lay down bc hypotension

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15
Q

How often can you give a sublingual nitrate and how many times before reporting to the emergency room?

A

Give 3 doses 5 min apart

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16
Q

What is the suffix for Beta Blockers?

A
"-olol"
atenolol 
metoprolol 
propanolol 
nadolol
17
Q

Actions of beta blockers

A

Lowers blood volume and causes vasodilation; decreases release of renin

18
Q

When are beta blockers indicated?

A

Tx of stable angina pectoris and hypertension; prevents reinfarction in MI pts, treats stable CHF

19
Q

When would you not give a beta blocker?

A

Bradycardia, heart block, cardiogenic shock- b/c heart is already less functional, asthma COPD, pregnancy/ lactation

20
Q

Why should you be careful giving beta blockers to a diabetic?

A

It can mask symptoms of hypoglycemia

21
Q

ADE of Beta blockers

A

r/t blockage of SNS
CNS- dizziness, fatigue, emotional depression
GI- N/V, colitis
Respiratory- bronchospasm, dyspnea, cough

22
Q

Drug/ Drug interactions w/ Beta Blockers

A

Clonidine

NSAIDs

23
Q

T/F Beta Blockers can be stopped immediately

A

FALSE- must be tapered over 2 weeks to avoid rebound hypertension

24
Q

Beta Blocker Prototype

A

Metoprolol

25
Q

Calcium Channel Blocker Medications

A
most end in "-odpine" 
amlodipine 
diltiazem 
nicardipine 
nifedipine 
verapamil
26
Q

Action of Calcium Channel Blockers

A

inhibits the movement of calcium, altering the action potential and blocking the muscle cell contraction

27
Q

Indications for Calcium Channel blockers

A

Prinzemetal’s angina

28
Q

When are calcium channel blockers contraindicated?

A

allergy, heart block or sick sinus syndrome, renal/ hepatic dysfunction, pregnancy/ lactation

29
Q

ADE of Calcium Channel Blockers *

A

*hypotension
*cardiac arrhythmia
GI upset
skin reactions
H/A

30
Q

Drug/ Drug interactions of Calcium Channel Blockers

A

Cyclosporine

Dogoxin- can cause complete heart block and digoxin toxicity