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Pharm Exams > Mod 9- Drugs Affecting GI Motility > Flashcards

Mod 9- Drugs Affecting GI Motility Flashcards

1
Q

T/F children can have more severe electrolyte imbalances if given antidiarrheal agents

A

TRUE- monitor more closely

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2
Q

What is cathartic dependence?

A

When you rely on an outside stimulation to poop

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3
Q

These laxatives Chemically irritate the lining of the GI tract

A

Chemical stimulants

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4
Q

These laxatives Cause the fecal matter to increase in bulk

A

bulk stimulants

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5
Q

These laxatives Help the intestinal contents move more smoothly

A

lubricants

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6
Q

These are examples of chemical stimulants

A

Bisacodyl
Castor Oil
Senna

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7
Q

These laxatives work by irritating the nerve plexus

A

Chemical stimulants
Bisacodyl
Castor Oil
Senna

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8
Q

These laxatives can precipitate early labor for someone who is pregnant

A

chemical stimulants

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9
Q

This is an ADE of the chemical stimulant castor oil

A

blocks absorption of fats and fat-soluble vitamins- nutritional deficiency

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10
Q

These are examples of bulk stimulants

A

Methylcellulose
Polycarbophil
Psyllium- best choice for older adults

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11
Q

These can cause pre-term labor

A

bulk stimulants

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12
Q

When should we give bulk stimulants in relation to other drugs

A

30 min. apart at least depending on medication

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13
Q

How do osmotic laxatives work?

A

Draw more water into GI tract and stimulate increased GI motility

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14
Q 
Magnesium
Lactulose 
Polyethylene glycol
Sodium picosulfate with magnesium oxide
Are examples of what type of laxatives
A

Osmotic laxatives

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15
Q

Contraindications of osmotic laxative- lactulose

A

appendicitis, acute surgical abdomen, fecal impaction, intestinal obstruction- pulling fluid won’t clear impaction

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16
Q

Lactulose, osmotic laxatives, should be used in caution for people with

A

diabetes

17
Q

Magnesium, an osmotic laxative, should be used in caution for people with

A

Renal insufficiency- can have build up of magnesium

18
Q

Polyethylene glycol, an osmotic laxative, should be used with caution for a pt with

A

seizures

19
Q

Prototype for osmotic laxatives

A

Magnesium citrate

20
Q

These are examples of lubricant laxatives

A

Docusate- Has a detergent action on the surface of the intestinal bolus, making a softer stool
Glycerin- Hyperosmolar laxative used to gently evacuate the rectum without systemic effects higher in the GI tract- suppository for children & young infant
Mineral Oil- Forms a slippery coat on the contents of the intestinal tract

21
Q

Use caution for these people if giving them lubricant laxatives

A

Heart block, CAD, debilitation

Pregnancy and lactation

22
Q

Almost all laxatives cause these ADE

A

CNS: dizziness, headache, weakness

Sweating, palpitations, flushing, fainting

23
Q

The lubricant, mineral oil, can have this drug/ drug interaction

A

Frequent use of mineral oil can interfere with absorption of the fat-soluble vitamins A, D, E, and K

24
Q

T/F Laxatives should NOT be chewed and swallowed with a full glass of water

A

TRUE

25
Q

Why wouldn’t we give a laxative to someone with acute abdominal pain, nausea or vomiting

A

We need to find out first what is the underlying cause

26
Q

This drug is a gastrointestinal stimulant

A

metoclopramide

27
Q

How do gastrointestinal stimulants work?

A

Stimulate parasympathetic activity within the GI tract

Increase GI secretions and motility

28
Q

When would a gastrointestinal stimulant be indicated?

A

Rapid movement of GI contents is desirable

Diabetic gastroparesis- delayed digestion

29
Q

Why are gastrointestinal stimulants contraindicated for a GI obstruction?

A

Something is obstructing the bowels and impacting more against it will make it worse

30
Q

What effect do gastrointestinal stimulants have on the CV system?

A

decreased blood pressure and heart rate

Weakness and fatigue

31
Q

Drug/ Drug interactions of GI Stimulants

A

Digoxin
Cyclosporine
Alcohol

32
Q

When would we administer GI Stimulants

A

Administer at least 15 minutes before each meal and at bedtime

33
Q

Why do we monitor diabetics given GI Stimulants?

A

bc it can effect absorption of things

34
Q

How do antidiarrheal drugs work?

A

Slow the motility of the GI tract through direct action on the lining of the GI tract

35
Q

What are some antidiarrheal drugs?

A

Bismuth Subsalicylate
Loperamide
Opium Derivatives

36
Q

When are antidiarrheal drugs indicated?

A

Relief of symptoms of acute or chronic diarrhea
Reduction of volume of discharge from ileostomies
Prevention and treatment of traveler’s diarrhea

37
Q

ADE of antidiarrheal drugs

A 
Constipation
Abdominal distension
Abdominal discomfort
Nausea
Dry mouth
Toxic megacolon
Fatigue
Weakness
Dizziness

Pharm Exams (25 decks)

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