Mod 1: Clinical Correlates Flashcards
Coxa vara
Coxa valga
Coxa vara: NSA too SMALL – MEDIAL deviation of shaft relative to the neck
–can be due to rickets (reduce bone quality during growth)
Coxa valga: NSA too LARGE – LATERAL deviation of shaft relative to neck
–can be due to slipped capital epiphyses during growth
**normal adult neck-shaft angle is 124-135 deg
**less active urban pop have higher values
**lower values as age inc
**both associated with inc risk of patello-femoral OA due to deviated pull of quads
Femoral fractures
Neck fractures most common
**direct impact injuries
**osteoporosis –old
**treat quickly to prevent femoral head necrosis as result of interuption of blood supply (med femoral circumflex a)
Shaft fractures more common in younger, more active people
**direct trauma
**may be comminuted
Muscles in what compartment of thigh atrophy rapidly with disease or disuse?
Ant compartment (extensors of knee)
Duchenne’s muscular dystrophy
progressive muscle weakness
inability of contractile apparatus to anchor properly without DYSTROPHIN
Gower’s sign is early diagnostic feature
Adipose tissue replaces muscle
Gower’s sign
Gower’s sign indicates a patient that must use its
arms to “walk up” their body from a squatting
position due to weakness of the hip and leg muscles.
–indicates Duchenne’s muscular dystrophy
Nemaline myopathy
mutations to NEBULIN, TROPOMYOSIN, TROPONIN
presence of rods/nemaline bodies in skeletal muscle fibers
Myasthenia gravis
- -autoimmune disorder
- -progressive muscle weakness and fatigability
- -weakness caused by REDUCTION in number of functional ACETYLCHOLINE RECEPTORS in SARCOLEMMA of END PLATE
- -circulating ANTIBIDIES BIND TO RECEPTORS
Dilated cardiomyopathy/ congestive heart failure
if PLN superinhibitory or chronically inhibitory, contractility is reduced
dilated cardiomyopathy: heart enlargement resulting in inability to pump blood efficiently (myocardium)
Treatment for spastic medial rotation and adduction of thigh in cerebral palsy
transect ant branch
Boundaries of femoral triangle
sup: inguinal ligament
lat: sartorius
med: adductor longus
floor: pectineus (medially) and iliopsoas (laterally)
roof: cribiform fascia centrally and tough fascia lata circumferentially
Contents of femoral triangle
Femoral nerve
Femoral artery
Femoral vein
Deep inguinal nodes and associated channels
What are the contents of the fibrous femoral sheath
Femoral a, v
Deep inguinal nodes and associated channels
Where does great saphenous vein pierce?
Where does it empty into?
Pierces cribiform fascia and femoral sheath to empty into the femoral v
What is the most common site for hernias in women?
femoral triangle – hernias of small intestine
Boundaries of popliteal fossa
superomedially: semimembranosus
superolaterally: biceps femoris
inferiorly: lat and med heads of gastrocnemius
Contents of popliteal fossa
popliteal a and v tibial n common fibular n small saphenous v popliteus plantaris soleus
Branches of popliteal a in popliteal fossa
sup lat genicular
sup med
inf lat
inf med
Popliteal aneurysm
dilations of popliteal a larger than 2 cm diameter
most common aneurysm in periph vasculature
occurs bilaterally in half of pts
can cause distal limb ischemia if associated with thrombus that leads to embolism
15% of pts with acute ischemia eventually require amputation of leg
up to 40% of pts with popliteal aneurysm will also have abdominal aortic aneurysm
Unhappy triad
ACL
TCL
medial meniscus (however, lat meniscus tars more common with ACL and TCL tears)
Ant drawer sign
test ACL integrity
Post drawer sign
test PCL integrity
Alzheimer’s and defective plasma membrane
gamma secretase does not chop amyloid beta protein (which is then supposed to go inside cell to regulate gene expresssion)
mutation in gamma secretase –> accumulation of amyloid beta protein –> plaque
Fc receptor involved in what phagocytic process?
Nonspecific receptor?
Fc: phagocytosis of foreign bio molec
Nonspecific: dirt/debris (nonbio)
Dynamin involved in what process?
What kind of protein is it?
Receptor-mediated endocytosis (w/ clathrin)
GTPase
What is a type of cell that uses clathrin endocytosis?
steroid hormone secreting cell
Leg bone fractures
tibia and fibula often shattered together breaks midshaft (weakest here) open fractures (esp at ant surface of tibia)
Fractures at distal locations of leg bones due to
skiing accidents – leg is bent over top of rigid ski boot
Diagonal fracture of tibia and fibula result in…
shortening
What prevents bow-stringing of muscles of ant compartment of leg?
sup and inf extensor retinaculum
Ant compartment syndrome
Elevated pressure following fracture (hemorrhage and edema) exacerbated by casting exceeds arterial pressure –> ischemia and tissue death
Treat: fasciotomy
Muscles and neurovasculature of ant compartment surrounded by imcompressible tissues with little room for expansion
Pain due to perforating branch of deep fib n
5 P’s of ACS
Pain Pallor Paraesthesia Pulselessness Paralysis
Shin splints
overexertion injury involving tibialis ant
Overuse of muscle causes tears in periosteum of ant tibia – pain
Symptoms of abnormal mito
poor growth
loss of muscle corrdination, muscle weakness
visual/hearing problems
developmental delays, learning disabilities
mental retardation
heart, liver, kidney disease
GI disorders, severe constipation
Parkinson’s disease is result of …
improper balance of fusion/fission of mito
deterioration of nerve cells in part of brain that controls mvmt
dopamine produced in this area, but damage reduces levels
insufficient dopamine disturbs balance b/w dopamine acetylcholine –> loss of muscle function
Drugs for Parkinson’s target
boost mitophagy
Uterus: gravid vs normal
HYPERTROPHY (inc cell size)
Cell change prior to menses in uterine rugal folds
hyperplasia (change in cell number)
–inc in number of cells in uterine glands and endometrial blood vessels
Dysplasia
REVERSIBLE replacement of DIFFERENTIATED cell type with an earlier, DE-DIFFERENTIATED form of the same cell type
Metaplasia
REVERSIBLE replacement of one differentiated cell type with another MATURE cell type
Change in cell type if person stops smoking
metaplasia (normal columnar epithelium become squamous metaplasia)