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Step 2 > MOA of medications > Flashcards

MOA of medications Flashcards

1
Q

How does Memantine work?

A

NMDA antagonist slowing influx of calcium which halts cell destruction

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2
Q

How do benzos work?

A

They enhance the effect of GABA at teh GABA receptor

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3
Q

MAOis work on both MAO-A and MAO-B, which works selectively on MAO-B at lower doses?

A

Selegiline

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4
Q

What does MAO-A metabolize?

A

serotonin and norepinephrine, dopamine

tyramine in the gut

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5
Q

What does MAO-B metabolize?

A

phenylethylamine, dopamine

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6
Q

how does sildenafil, vardenafil, and tadalafil work?

A

nonselective phosphodiesterase inhibitors

- cannot be used with NO agonist (nitrates)

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7
Q

ramelteon

A

melatonin agonist in suprachiasmatic nucleus of hypothalamus
8mg qhs

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8
Q

z-drugs work at what recptor

A

benzo receptor agonist

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9
Q

zaleplon (sonata)

A

shortest half life 1 hour

compared to ramelteon (2.5/5), zolpidem (2.5-4.5), eszopiclone (6 hrs)

-useful for middle of the night insomnia

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10
Q

naloxone

A

opioid antagonist

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11
Q

naltrexone

A

opioid antagnoist w/ half life of 72 hours

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12
Q

buprenorphine

A

mixed opioid agonist-antagonist

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13
Q

bromocriptine

A

mixed dopamine agonist-antagonist

used for parkinsons disease

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14
Q

riluzole

A

glutamate antagonist
FDA approved for ALS
-GI upset, fatigue, dizniness, liver enzyme elevation

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15
Q

tiagabine

A

gaba reuptake inhibitor

- adjunctive treatment for partial complex seizures

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16
Q

memantine

A

NMDA antagonist FDA approved for treatment of moderate to sever Alzheimers dementia

17
Q

GABA-A receptor is waht type of ion channel

A

chloride

18
Q

how does mirtazapine work?

A

blocking presynaptic alpha 2 receptors which stops feedback inhibition on the release of NE into the synaptic cleft. results in more NE released

  • antagonism of presynaptic alpha 2 receptors leads to potentiation of serotonergic and noradrenergic neurotransmission
  • lacks anticholergic side effects, lacks sexual side effects, lacks anxiogenic side effects
19
Q

MAO of triptans

A

agonist at 5HT 1B and 5HT1D

- modulate the excitability of cells in the trigeminal nucleus caudalis

20
Q

Mirtazapine has 5HT3 antagonism what is this thought to be responsible for?

A

antinausea

Step 2 (27 decks)

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