Dont give these drugs together/dont eat this! Flashcards
Dont give MAOi with?
Meperidine
What type of MAOi can you have tyramine?
Moclobemide and the selegiline patch only weakly potentiate the pressor effects of tyramine
What drugs increase TCA concentrations and how?
Antipsychotic drugs and methylphenidate increase TCA concentrations through their interaction with CYP P450.
Other drugs that increase TCA concentrations include acetazolamide, aspirin, cimetidine, thiazides, fluoxetine, and sodium bicarbonate
- Cigarette smoking decreases their concentration through its action on the cytochrom P450 1A2 enzyme, other drugs that decrease TCA include ascorbic acid, lithium, barbiturates, and primidone
Can you use diazepam with liver failure?
No it needs oxidative metabolism by the liver
What CYP is valproate a classic inhibitor of?
3A4, which causes inhibition of clearance of lamcital
Don’t give MAOIs with what?
- MEPERIDINE
- anesthetics (no spinal anesthetics, no anesthetics containing epinephrine)
- dextromethorphan
- sympathomimetics (epinephrine, amphetamines, cocaine)
clozapine will increase when given with what?
cimetidine
SSRI
TCA
valproic acid
erythromycin
clozapine will decrease with what?
phenytoin and carbamazapine (should not be given with this because also can cause agranulocytosis)
clozapine should not be given with other drugs that can cause agranulocytosis such as
carbamazapine
propylthiouracil
sulfonamides
captopril
combination of lithium and clozaril can increase what?
NMS, seizure, confusion, movement disorders
what happens when erythromycin and carbamazepine are given together
carbamazapine levels are increased
What is fluoxetine an inhibitor of?
2d6
Carbamazepine, oxcarbazepine, phenytoin, and rifampin are all induces of what?
CYP3A4
what drug should clozapine not be given with
any drug that can cause agranulocytosis or bone marrow suppression
carbamazepine, phenytoin, propylthiouracil, sulfonamides, captopril
lithium should not be taken in cloazpine pts who have had what
NMS
