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CYP facts Flashcards

1
Q

CYP1A2
Substrates

A

TCA: Amitriptyline, Clomipramine, Imipramine
Antipsychotic: Clozapine, Haloperidol, Olanzapine
Antidepressant: Fluvoxamine, Mirtazapine

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2
Q

CYP1A2 Inducers

A

Cigarette smoking
Insulin
Modafinil
Omeprazol
Rifampin
Phenobarbitol

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3
Q

Cyp1A2 inhibitor

A

Fluvoxamine
Ciprofloxacin
Cimetidine
Amiodarone
Fluoroquinolones

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4
Q

CYP2C9 Substrates

A

Amitriptyline
Fluoxetine
Phenytoin
Sertraline

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5
Q

Cyp2C9 inducers

A

Phenobarbitol

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6
Q

CYP2C9 inhibitors

A

Fluvoxamine
Amiodarone
Fluconazole
Fluvastatin
Isoniazide
Lovastatin
Sulfamethoxazole
Rifampin

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7
Q

CYP2C19 substrates

A

TCA: Amitriptyline, Imipramine, Clomipramine
SSRI: Fluoxetine, escitalopram, citalopram, sertraline
Anxiolytic: diazepam
Other: Phenytoin, propranolol

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8
Q

CYP2C19 Inducers

A

Carbamazepine, prednisone, rifampin

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9
Q

CYP2C19 Inhibitors

A

Fluvoxamine, Modafinil, Cimetidine, Indomethacin, Ketoconazole, Lansoprazole, Omeprazole, Oxcarbazepine, Topiramate

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10
Q

Cyp2D6 Substrates

A

SSRI/SNRI: Citalopram, duloxetine, escitalopram, fluoxetineparoxetine , venlafaxine
TCA: Amitriptyline, Clomipramine, imipramine, desipramine
Antipsychotic: Aripiprazole, Chlorpromazine, haldol, thorazine
Other: Amphetamine, atomoxetine, mirtazpine

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11
Q

CYP2D6 induceers

A

Dexamethasone, Rifampin

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12
Q

Cyp2D6 Inhibitor

A

SSRI/SNRI: Duloxetine, fluoxetine, paroxetine, fluvoxamine
TCA: Clomipramine
Antipsychotic: Chlorpromazine, perphenazine*, thioridazine
Other: Bupropion, methadone
other other: cimetidine, diphenhydramine, hydroxyzine, ritonavir

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13
Q

CYP3A4 substrate

A

SSRI/SNRI: Citalopram, paroxetine, sertraline
TCA: Amitriptyline
MAOi:
Antipsychotic: Aripiprazole, quetiapine, risperidone
Anxiolytic: Alprazolam, Benzos
Other: Buspar, carbamazepine, methadone, mirtazapine, nefazodone, trazodone

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14
Q

CYP3A4 inducers

A

Barbituates, Carbamazepine, oxcarbamazepine, modafanil, phenobarbital, phenytoin, rifabutin, rafampin

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15
Q

CYP3A4 inhibitors

A

Paroxetine, Nefazodone, Clarifthromycin, fluvoxamine, amiodarone, cimetidine, cipro, dilt, erythromycin, fluconazole

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16
Q

nefazodone inhibits what?

17
Q

Paroxetine and fluoxetine are potent what

A

Paroxetine and fluoxetine are potent CYP 2D6 inhibitors.

18
Q

what will decrease lamotrigine levels

A

oral contraceptives
phenobarbitol
phenytoin

19
Q

stereotactic thalamotomy is used for what

A

parkinsons disease

20
Q

treatment for chorea in huntingtons

A

haloperidol

21
Q

what can decrease methadone blood levels?

A

phenytoin, dextromethorphan, abacavir, carbamazepine, cocaine, dexamethasone, nevirapine, rifampin, sprinolactone and tobacco products

22
Q

what can increase methadone

A

ciprofloxacin, erythromycin, disulfram, verapami, dihydroergotamine, grapefruit, moclobemide, echinacea

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