MKSAP - Hematology Flashcards
Patient with prolonged bleeding time and mild coagulopathy – diagnosis?
Von Willebrands disease
In the absence of inflammation, lower and upper limit of normal ferritin?
In patients with inflammatory disorder, and ferritin lower than 120, likely cause of anemia?
15; 30
Iron deficiency in setting of inflammatory anemia
Normal bleeding time, PT, PTT?
<10 minutes, 11–13 seconds, ??
Prior to surgery, only need to test for coagulation disorders if?
Positive family history, liver disease, anticoagulation therapy
Patient with suspected avascular necrosis/osteonecrosis – test?
- Plain radiograph
2. If normal X-Ray: MRI (if MRI contraindicated use radionuclide bone scan)
Patient with suspected HIT – management? Gold standard for diagnosis?
Stop heparin, start agatroban/lepirudin. Serotonin release assay.
Pseudo-thrombocytopenia?
Platelets agglutinate in clumps and are not recognized by blood counters
ITP – treatment?
Corticosteroids
Patient with previous PE who just finish a course of warfarin. Family history of DVT’s – next step?
Thrombophilia screening two weeks after completion of warfarin
Hypercalcemia in presence of acute kidney injury suggests?
Most common initial finding these patients?
Multiple Myeloma
Renal failure
G6PD deficiency – symptoms? Smear findings? Lab findings?
Jaundice and dark urine (with or without abdominal/back pain)
Bite cells and Heinz bodies
Increased reticulocytes
Spherocytes on peripheral blood smear suggest? Test to differentiate?
Hereditary spherocytosis or warm antibody-mediated hemolysis
Direct antigobulin test is positive in warm antibody-based mediated hemolysis
Symptoms of macroangiopathic versus microangiopathic hemolytic anemia?
Appears well, no evidence of organ dysfunction, normal platelet count versus opposite
Warm antibody-mediated hemolytic anemia – common complication of?
Lymphoid malignancies
Mixing studies differentiate between?
Factor deficiency versus presence of inhibitor
