Heme - Vasculitis

Question 0

Polyarteritis nodosa will never affect?

Answer 0

The lungs

Question 1

Nearly All vasculitis diseases present with?

Answer 1

#Fever
#Weight-loss
#Arthralgia/myalgia

Question 2

Clinical features of polyarteritis nodosa?

Answer 2

#Renal – GN
#Neurologic – Mononeuritis multiplex (foot drop) or stroke in young person
#G.I. – abdominal pain worsened with eating; bleeding;
#Skin – lower extremity ulcers, livedo reticularis, purpura

Question 3

Mononeuritis multiplex?

Answer 3

Multiple peripheral neuropathies of nerves large enough to have a name

Question 4

Most accurate test to diagnose polyarteritis nodosa? Angiography would show?

Answer 4

Biopsy

Abnormal dilation (beading)

Question 5

Best treatment for polyarteritis Nodosa?

Answer 5

Steroids and cyclophosphamide

Question 6

Test all polyarteritis nodosa patients for?

Answer 6

Hepatitis B and C

Question 7

Wegener’s granulomatosis presents with what respiratory tract findings?

Answer 7

#Sinusitis
#otitis media
#Mastoiditis
#gingival involvement

Question 8

ESR, CPK and aldolase in polymyalgia rheumatica? Treat with?

Answer 8

Elevated, Normal, normal

Steroids

Question 9

Best initial test for Wegener’s disease? Most accurate test for Wegener’s disease?

Answer 9

C-ANCA

Lung biopsy > renal biopsy > sinus biopsy

Question 10

Differentiating Churg Strauss from Wegener’s?

Answer 10

Asthma and eosinophilia

Question 11

Findings seen in HSP?

Answer 11

Skin purpura, joint arthralgia, hematuria, G.I. bleeding

Question 12

HSP – do not test for? When to give steroids? Limitation of steroids?

Answer 12

IgA

Severe abdominal pain with progressive renal insufficiency

Will not reverse renal insufficiency

Question 13

Cryoglobulinemia associated with?

Answer 13

#Chronic hepatitis C
#Endocarditis
#Connected tissue disorders – Sjögren's

Question 14

Cryoglobulin versus cold agglutinin – associated with? Clinical manifestations? Treatment?

Answer 14

Hepatitis C versus EBV/mycoplasma/lymphoma

joint, kidney, skin, neuro findings versus hemolysis

Hep C meds versus rituximab, cyclophosphamide, cyclosporine

Question 15

Behcet’s syndrome?

Answer 15

Oral ulcers, arthritis, ocular lesions and pathergy

Mouth, eyes, joints, skin

Question 16

Pathergy?

Answer 16

Sterile skin pustules from minor trauma with needlesticks

Question 17

Ocular and cardiac findings of ankylosing spondylitis?

Answer 17

#Uveitis
#AV block or aortic insufficiency

Question 18

Best initial test for ankylosing spondylitis? Most accurate test?

Best initial treatment?

Answer 18

X-ray of sacroiliac joint

MRI

Exercise and NSAIDs. If fails, anti-TNF

Question 19

For seronegative arthropathies, do not treat with?

Answer 19

Steroids