Miscellaneous

Question 1

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Answer 1

Children with DiGeorge Syndrome are especially at risk for viral and fungal infections, due to lack of T cell development secondary to the failure of development of the thymus

Question 2

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Answer 2

Prednisone is often used to treat patients with sarcoid who have hypercalcemia. The glucocorticoids suppress 1-alpha hydroxylase activity, which will –> decreased vitamin D activation –> decreased Ca absorption

Question 3

What is the physiologic cause of benign prostatic hyperplasia (BPH)?

Answer 3

Ultimately due to an excess of DHT (dihydrotestosterone)

Question 4

What is the activated form of prednisone?

Answer 4

Prednisolone

Prednisone must be reduced to its active form for its anti-inflammatory effects to occur. The enzyme that catalyzes this reaction is 11 beta-hydroxysteroid dehydrogenase.