Classic Labs/Findings: Lab/Diagnostic Finding//Diagnosis/Disease Flashcards
Anticentromere antibodies
Scleroderma (CREST)
Antihistone antibodies
Drug-induced SLE
hydralazine, INH, phenytoin, procainamide
Antinuclear antibodies (ANAs: anti-Smith and anti-dsDNA)
SLE (type III hypersensitivity)
Antiplatelet antibodies
Idiopathic thrombocytopenic purpura (ITP)
Basophilic nuclear remnants in RBCs
Howell-Jolly bodies (due to splenectomy or nonfunctional spleen)
Bloody tap on LP
Subarachnoid hemorrhage
Stacks of RBCs
Rouleaux formation (high ESR, multiple myeloma)
Psammoma bodies
Meningiomas
papillary thyroid carcinoma
mesothelioma
papillary serous carcinoma of the endometrium and ovary
Pseudopalisading tumor cells on brain biopsy
Glioblastoma multiforme
Heterophile antibodies
Infectious mononucleosis (EBV)
High level of D-dimers
DVT
PE
DIC
Hypochromic, microcytic anemia
Iron deficiency anemia
lead poisoning
thalassemia (fetal hemoglobin sometimes present)
Lytic (“hole punched”) bone lesions on x-ray
Multiple myeloma
Hypersegmented neutrophils
Megaloblastic anemia (B12 deficiency: neurologic symptoms; folate deficiency: no neurologic symptoms)
Needle-shaped, negatively birefringent crystals
Gout (monosodium urate crystals)
Depigmentation of neurons in the substantia nigra
Parkinson disease (basal ganglia disorder: rigidity, resting tremor, bradykinesia)
Extracellular (A-beta) amyloid deposition in gray matter of brain
Senile plaques (Alzheimer disease)
Giant B cells with bilobed nuclei with prominent inclusions (“owl’s eyes”)
Reed-Sternberg cells (Hodgkin lymphoma)
“Hair on end” (crew-cut) appearance on x-ray
Beta-thalassemia, sickle cell anemia (marrow expansion)
Basophilic stippling of RBCs
Lead poisoning or sideroblastic anemia
Anti-topoisomerase antibodies
Diffuse systemic scleroderma
Anti-glomerular basement membrane antibodies
Goodpasture syndrome (glomerulonephritis and hemoptysis)
Degeneration of dorsal column nerves
Tabes dorsalis (Tertiary syphilis)
(differentiated from subacute combined degeneration [B12 deficiency], where dorsal columns and lateral corticospinal tracts are affected)
Silver-staining spherical aggregation of tau proteins in neurons
Pick bodies (Pick disease: progressive dementia, changes in personality)
Sheets of medium-sized lymphoid cells with scattered pale, tingible body-laden macrophages (“starry sky” histology)
Burkitt lymphoma (t:[8;14] c-myc activation, associated with EBV; “black sky” made up of malignant cells)
