Endo 2

Question 1

What three enzymes are necessary for the production of aldosterone, cortisol, and sex hormones?

Answer 1

11 beta-hydroxylase

17 alpha-hydroxylase

21-hydroxylase

Question 2

With 17 alpha-hydroxylase deficiency, how would the levels of aldosterone, cortisol, and sex hormones be affected?

Answer 2

aldosterone levels would increase

cortisol and sex hormone levels would decrease

Question 3

What three characteristic findings would we see on labs with 17 alpha-hydroxylase deficiency.

Answer 3

1. HTN
2. Hypokalemia
3. decrease in DHT

Question 4

What four characteristic findings would we see on labs with 21-hydroxylase deficiency.

Answer 4

1. Hypotension
2. Hyperkalemia
3. Increased renin activity
4. increased 17-hydroxyprogesterone

Question 5

With 21-hydroxylase deficiency, how would the levels of aldosterone, cortisol, and sex hormones be affected?

Answer 5

Aldosterone and Cortisol would be decreased.

Sex hormones would be increased

Question 6

With 11 beta-hydroxylase deficiency, how would the levels of aldosterone, cortisol, and sex hormones be affected?

Answer 6

Aldosterone and cortisol would be decreased.

Sex hormones would be increased.

**However, 11-deoxycorticosterone would be increased. This is an aldosterone precursor, which would result in high BP

Question 7

What characteristic finding would we see on labs with 11 beta-hydroxylase deficiency? (1)

Answer 7

In this case, you would see high BP because the levels of an aldosterone precursor (11-deoxycorticosterone) would be increased.

Question 8

What characteristics are common to all congenital adrenal enzyme deficiencies?

Answer 8

In all three congenital enzyme deficiencies, cortisol levels are low. Therefore, all three deficiencies are characterized by an enlargement of both adrenal glands due to increased ACTH, secondary to decreased cortisol.