MIDTERM - HEMOGLOBIN METABOLISM Flashcards
(150 cards)
iron bearing protein contained
within the erythrocytes .
hemoglobin
one gram of hemoglobin can carry
____ of oxygen
1.34 ml
The concentration of hemoglobin within RBCs is approximately ____ and its molecular weight is
approximately ____.
34 g/dL; 64,000 Daltons
what are the main function of hemoglobin
transport oxygen from lungs to tissue, carbon dioxide from tissue to lungs.
contributes to acid-base balance by binding and releasing hydrogen ions and
transport nitric oxide (a regulator of vascular tone)
a regulator of vascular tone
nitric oxide
Hemoglobin is the first protein whose structure was described
using _____.
x-ray crystallography
-
-
carbon, hydrogen, nitrogen
the ring of heme composed of carbon, hydrogen, and nitrogen is called as
protoporphyrin IX
what is the central atom found in the heme of the hemoglobin
ferrous iron
When the ferrous irons are oxidized
to the ferric state (Fe3+), they no longer can bind oxygen.
true or false
True
Oxidized hemoglobin is also called ___
methemoglobin
describe the globin strcture
The four globin chains comprising each hemoglobin molecule
consist of two identical pairs of unlike polypeptide chains, 141 to
146 amino acids each.
in globin structure, each globin chain is divided into how many helices and non helices
divided into eight helices separated by
seven nonhelical segments
Hemoglobin is a tetramer of four globin chains with a heme attached
to each globin chain.
true or false
true
globin chain alpha and its number of amino acids
141
globin chain beta and its number of amino acids
146
aside from globin chain alpha, what is the globin chain that has 141 amino acids as well?
globin chain zeta
how many amino acids do theta has?
unknown
the hemoglobin molecule can be describe as its
primary
secondary
tertiary
quaternary structures
the structure of hemoglobin that refers to the amino acid sequence of the POLYPEPTIDE CHAINS
primary structure
the structure of hemoglobin that refers to chain arrangements in HELICES and NON HELICES
secondary structure
the structure of hemoglobin that refers to the
arrangement of the helices into a PRETZEL LIKE CONFIGURATION
tertiary hemoglobin
The quaternary structure of hemoglobin, also called a _____, describes the complete hemoglobin molecule
tetramer
The complete hemoglobin molecule is SPHERICAL, has four heme groups
attached to four polypeptide chains, and may carry up to
four molecules of oxygen
true or false
true