microcytic anaemia Flashcards

1
Q

icrocytic anaemia, the causes of which can be broadly categorised into

A

1, iron deficiency,
2, thalassaemia trait
3, sideroblastic anaemia.

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2
Q

iron deficiency anaemia blood results ?

A

normal transferrin saturation and normal ferritin

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3
Q

thalessemia diagnosis ?

A

Hb electrophoresis

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4
Q

sideroblastic anemia diagnosis ?

A

high ferritin
high iron
high transferrin saturation

blood film
basophilic stippling of red blood cells

bone marrow
Prussian blue staining will show ringed sideroblasts

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5
Q

what is sideroblastic anemia ?

A

red cells fail to completely form haem, whose biosynthesis takes place partly in mitochondrion.

leads to deposits of iron in mitochondria that form a ring around the nucleus called a ring sideroblast.

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6
Q

congenital cause o sderoblastic anemia ?

A

delta-aminolevulinate synthase-2 deficiency

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7
Q

acquired cause of sideroblastic anemia ?

A

myelodysplasia
alcohol
lead
anti-TB medications

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