microcytic anaemia Flashcards
icrocytic anaemia, the causes of which can be broadly categorised into
1, iron deficiency,
2, thalassaemia trait
3, sideroblastic anaemia.
iron deficiency anaemia blood results ?
normal transferrin saturation and normal ferritin
thalessemia diagnosis ?
Hb electrophoresis
sideroblastic anemia diagnosis ?
high ferritin
high iron
high transferrin saturation
blood film
basophilic stippling of red blood cells
bone marrow
Prussian blue staining will show ringed sideroblasts
what is sideroblastic anemia ?
red cells fail to completely form haem, whose biosynthesis takes place partly in mitochondrion.
leads to deposits of iron in mitochondria that form a ring around the nucleus called a ring sideroblast.
congenital cause o sderoblastic anemia ?
delta-aminolevulinate synthase-2 deficiency
acquired cause of sideroblastic anemia ?
myelodysplasia
alcohol
lead
anti-TB medications