AML Flashcards
C
C
V
blood investigation for AML ?
neutropenia: whilst white cell counts may be very high, functioning neutrophil levels may be low leading to frequent infections etc
thrombocytopenia: bleeding
Clinical features of AML?
anaemia: pallor, lethargy, weakness
splenomegaly
bone pain
What are the poor prognostic factors in AML?
Cytogenetic -
deletions of chromosome 5 or 7 = POOR PROGNOSIS
Age > 60 years
> 20% blasts after first course of chemo
Acute promyelocytic leukaemia M3 presentation
DIC or thrombocytopenia often at presentation
Diagnostic feature of AM3 - Acute promyelocytic leukaemia M3
Auer rods (seen with myeloperoxidase stain)
Acute promyelocytic leukaemia M3
associated with what translocation ?
t(15;17)
Acute promyelocytic leukaemia M3?
presents younger than other types of AML (average = 25 years old)
does Acute promyelocytic leukaemia M3 have good prognosis ?
yes
diagnosis of aml ?
8;21