ITP

Question 1

Patho etiology if ITP?

Answer 1

immune-mediated reduction in the platelet count. Antibodies are directed against the glycoprotein IIb/IIIa or Ib-V-IX complex.

Question 2

ITP presentation

Answer 2

may present with
petechiae, purpura

bleeding (e.g. epistaxis)

catastrophic bleeding (e.g. intracranial) is not a common presentation

Children with ITP usually have an acute thrombocytopenia that may follow infection or vaccination

Question 3

Diagnosis of ITP?

Answer 3

isolated thrombocytopenia

bone marrow examination is no longer used routinely

Question 4

Management of ITP

Answer 4

Emergency treatment: life-threatening or organ threatening bleeding :- Platelet transfusion, IV methylprednisolone and intravenous immunoglobulin

Platelet count <30*109/L - oral prednisone

Platelet count >30*109/L - observation

Question 5

What is evans syndrome in ITP

Answer 5

ITP in association with autoimmune haemolytic anaemia (AIHA)