immunoglobulins and their function

Question 1

IgG function ?

Answer 1

Enhance phagocytosis of bacteria and viruses

Fixes complement and passes to the fetal circulatio

Question 2

Most abundant isotype ig blood serum

Answer 2

igG

Question 3

most predominant ig founding breast milk ?

Answer 3

gA is the predominant immunoglobulin found in breast milk.

Question 4

function of IgA

Answer 4

found in the secretions of digestive, respiratory and urogenital tracts and systems
* Provides localized protection on mucous membranes

Question 5

most commonly produced igG?

Answer 5

igA
(but blood serum concentrations lower than IgG

Question 6

first immunoglobulin to be secreted in response to infection ?

Answer 6

igm

Question 7

Fixes complement but does not pass to the fetal circulation

Answer 7

igM

Question 8

Function of Igm?

Answer 8

Anti-A, B blood antibodies (note how they cannot pass to the fetal circulation, which could of course result in haemolysis)

first for infection response

Question 9

shape of IgM ?

Answer 9

PENTAMER - therefore cannot pass - most other igG is a monomer

Question 10

function of IgD ?

Answer 10

Role in immune system largely unknown
* Involved in activation of B cells

Question 11

Function of IgE ?

Answer 11

type 1 hypersensitivity reactions

Binds to Fc receptors found on the surface of mast cells and basophils

• Provides immunity to parasites such as helminths

Question 12

IgE is synthesised by ?

Answer 12

plasma cells

Question 13

least abundant ig ?

Answer 13

ig E