HYPERSENSITIVITY TEST

Question 1

Gell and Coombs classification divides hypersensitivity traditionally divides reactions into 4 types which are :

Answer 1

Type I - Anaphylactic

Type II - Cell bound

Type III - Immune complex

Type IV - Delayed hypersensitivity - T cell mediated

Question 2

Examples of type 1 hyper sent ivory reaction

Answer 2

Anaphylaxis

• Atopy (e.g. asthma, eczema and hayfever)

Question 3

Type II - Cell bound examples

Answer 3

Autoimmune haemolytic anaemia
• ITP
• Goodpasture’s syndrome
• Pernicious anaemia
• Acute haemolytic transfusion reactions
• Rheumatic fever
• Pemphigus vulgaris / bullous pemphigoid

Question 4

Type III - Immune complex

Answer 4

SLE
Serum sickness
Post strep glomerulonephritis

Question 5

Examples of type 4 hypersensitivity ?

Answer 5

T cell mediated

Tuberculosis / tuberculin skin reaction

• Graft versus host disease

• Allergic contact dermatitis

• Scabies

• Extrinsic allergic alveolitis (especially chronic phase)

• Multiple sclerosis

• Guillain-Barré syndrome

Question 6

Examples of type 5 hypersensitivity ?

Answer 6

Graves’ disease
• Myasthenia gravis