Heparin-induced thrombocytopaenia (HIT) Flashcards
1
Q
mechanism of action of Heparin-induced thrombocytopaenia (HIT)?
A
immune mediated - antibodies form against complexes of platelet factor 4 (PF4) and heparin (type 2 hypersensitivity )
2
Q
time when Heparin-induced thrombocytopaenia (HIT) occurs after giving heparin ?
A
after 5-10 days
3
Q
Hit is a what condition ?
A
despite being associated with low platelets
HIT is actually a prothrombotic condition
4
Q
which type of heparin causes HIT to occur more ?
A
standard heparin
(LMWH has lower risk of HIT )
5
Q
x
A
6
Q
xx
A
7
Q
clinical features of HIT ?
A
thrombosis and skin allergy
8
Q
x
A
9
Q
x
A
10
Q
x
A
11
Q
x
A
12
Q
x
A
13
Q
diagnosis of HIT ?
A
greater than 50% reduction in platelets,
14
Q
x
A
15
Q
x
A
16
Q
Mx of HIT ?
A
ongoing anticoagulation:
direct thrombin inhibitor e.g. argatroban
danaparoid
Dabigatran
