Mi - Global Health & Brain Worms Flashcards
what bug causes brain worms
tinea solium
what is a brain infection with tinea solium called
(tinea solium) cysterocosis
what does CT head show in cysterocosis
calcified spots through brain
cystic lesion with normal brain architecture
why is the gross brain architecture normal in cysterocosis
its very slow growing so doesn’t compress anything else
tinea solium is the most common cause of adult onset ____ worldwide
epilepsy
how do you get tinea solium cysterocosis
ingesting infected human faeces (usually by eating pork where the pig has feasted on infected human faeces)
which animal is infected by tinea solium
pigs (the pork has tapeworm larvae in)
what is taeniasis
tapeworm
which animal gets the cystic form of tinea solium and how does it affect them
pigs - affects CNS and get cysts all over body
how do the cysts evade the body’s immune system (4)
sequestration
fibrous encapsulation
molecular mimicry
modulation of host immunity
what causes the sx in cysterocosis
cyst degeneration
what is cysterocosis associated with
eosinophilic cellular influx
Mx of cysterocosis
anticonvulsants
albendazole and steroids
why are steroids given with abendazole for Mx of cysterocosis
prevent cerebral oedema
how is cysterocosis prevented
stopping pigs eating human faeces
hand hygiene / meat hygiene etc
what is the biggest driver of TB mortality / morbidity
poverty –> undernourishment
other drivers of TB mortality / morbidity
smoking
HIV
how is the most effective TB tx regime delivered
it is OBSERVED in clinics
completion rate of the observed TB Tx regime
56%
what % of complete Tx rates would lower the incidence of TB
90%
why is multi drug resistant TB adherence rates lower
it involves IM injections which is more invasive
