Ha - Emergency Morphology (E) Flashcards

1
Q

7 conditions in which an emergency blood film might be useful

A

malaria
acute anaemia
ITP / TTP
leukaemia / lymphoma
AKI
infection

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2
Q

how is babesiosis different to malaria on blood film

A

babesia microti - extracellular parasites and ring forms

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3
Q

PC of babesios

A

fever in an immunosuppressed person from USA (parasite endemic there)

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4
Q

who gets unusual infections in general

A

HIV+ patients

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5
Q

neutrophil morphology in megaloblastic anaemia

A

hypersegmented

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6
Q

4 blood film features of paroxysmal cold haemaglobinuria

A

agglutination
spherocytes
erythrophagocytosis
atypical lymphocytes

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7
Q

parvovirus blood film

A

no reticulocytosis suggesting red cell aplasia

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8
Q

how do you tell the difference between haemaglobinuria and haematuria

A

centrifuge the urine - haematuria will have red cells at bottom and urine at top

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9
Q

spherocytes and polychromatic macrocytes suggests what

A

haemolysis

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10
Q

4 important causes of anaemia in neonate

A

haemolytic disease of newborn
g6pd deficiency
maternal parvovirus infection
fetomaternal haemorrhage

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11
Q

what Ix is needed before giving platelets if the platelet count is low & why

A

confirmation from lab of automated count verification

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12
Q

is TTP an emergency

A

YES - untreated mortality rate is 90%

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13
Q

Tx for TTP

A

plasma exchange
steroids

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14
Q

what do leukaemia cells look like

A

primitive cells, cytoplasm full of granules

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15
Q

why is acute promyelocytic leukaemia an emergency

A

can rapidly die of DIC
increased fibrinolysis

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16
Q

features of HELLP syndrome

A

haemolysis
elevated LFTs
low platelets

17
Q

Tx of promyelocytic leukaemia

A

platelets
correction of hypofibrinogenaemia
all-trans-retinoic (ATRA)

18
Q

classical morphology of promyelocytic leukaemia

A

very varied but classical is hypergranular cells and Auer rods

19
Q

what condition is associated with burkitt’s lymphoma

A

AIDS

20
Q

causes of AKI that would be helpful to get a blood film for

A

multiple myeloma
haemolytic uraemic syndrome
TTP
tumour lysis syndrome in high grade blood cancers
AML / lymphoma with hyperuricaemia