Ha - Abnormal R/WCCs Flashcards
primary causes of high RCC
polycythaemia vera
thalassaemia
secondary causes of high RCC
high altitude
AI haemolytic anaemia
folate deficiecny + howell jolly bodies = ?
coeliac
fe def in post menopausal woman = ?
blood loss
features of leucoerythroblastic anaemia
teardrop RBCs
nucleated RBCs
immature myeloid cells
features of immune HA
most common anaemia
spherocytes
direct antiglobulin test positive (Coombs)
Inherited vs acquired causes of haemolytic anaemia
Inherited = hereditary spherocytosis, G6PD deficiency, sickle cell, thalassaemia
Acquired = immune HA, disease (SLE, lymphoma)
Blood film / test results of HA
reticulocytes
Bilirubinaemia
high MCV and LDH
low haptoglobins
progression of low grade DIC
platelet activation
fibrin deposition
RBC fragmentation
platelet consumption
causes of raised WCC
reactive neutrophillia
IM
ALL / AML
CLL
eosinophilia
causes of reactive neutrophilia
pyogenic infection
steroids / inflamm / ca
blood film features of reactive neutrophilia
no immature cells
toxic granulation
vacuoles
blood film features of ALL/AML
immature cells / myeloblasts
blood film features of CLL
mature cells, myelocytes, basophils
causes of eosinophilia
parasitic infection, asthma, neoplasm, drugs, leukaemia
Viral (6) / illness related causes of lymphocytosis
EBV, CMV, toxoplasma
Hepatitis, rubella, HSV
AI, sarcoid
lymphocytosis + mature cells = ?
CLL or IM
lymphocytosis + immature cells = ?
ALL
causes of lymphopenia
HIV or other AIDs / chemo
what type of b cells are seen in leukaemia?
light chain monoclonality - either k or lamda not both
