Ha - EFA Haem

Question 1

what electrolyte imbalance causes confusion in liver failure

Answer 1

hyperammonaemia

Question 2

high BR, high ALT, high lactate, low Hb. Dx?

Answer 2

acquired haemolytic anaemia

Question 3

which condition has peripheral blood film spherocytes:
- DAT + hereditary spherocytosis
- folate def anaemia
- G6PD def
- DAT+ AI haemolytic anaemia

Answer 3

DAt+ AI HA

Question 4

first line Tx for symptomatic AI HA

Answer 4

prednisolone

Question 5

DAT+ acquired HA may be seen in association with which other condition?

Answer 5

CLL
lymphoma

Question 6

which conditio ndoes not have bilateral cervical lymphadenopathy
- acute EBV
- follicular NHL
- MM
- HIV

Answer 6

MM

Question 7

what condition does not have a widened mediastinum
- teratoma
- thymoma
- HL
- B cell acute ALL
- B cell NHL

Answer 7

B cell ALL

Question 8

what is the cure rate of chemo for HL stage 1A

Answer 8

80%

Question 9

splenomegaly, generalised lymphadenopathy with high WCC. Dx?

Answer 9

CLL

Question 10

35F with malar rash. Dx

Answer 10

SLE

Question 11

what blood abnormality is seen in GVHD

Answer 11

pancytopenia

Question 12

what blood abnormality is seen in obstructive jaundice

Answer 12

ALP and BR ++ high
ALT high

Question 13

what blood abnormality is seen in hep E

Answer 13

high ALT and BR
transaminitis

Question 14

what blood abnormality is seen in pernicious anaemia

Answer 14

low Hb
high BR
high MCV

Question 15

is microangiopathic haemolytic anaemia acquired or inherited

Answer 15

inherited

Question 16

what RBCs are in microangiopathic haemolytic anaemia

Answer 16

fragments of RBCs

Question 17

what RBCs are seen in folate def anaemia

Answer 17

macrocytes

Question 18

what 2 conditions have hereditary spherocytosis

Answer 18

AI HA
hereditary spherocytosis

Question 19

what RBCs do you get in G6PD def

Answer 19

ghost cells

Question 20

mechanisms of acquired spherocyte production

Answer 20

Ig binds to RBC membrane
when RBC passes through spleen, the IG is recognised and damages the membrane
as the membrane is damaged, it rejoins and forms a smaller membrane with the same intracellular amount, thus making it spherical

Question 21

why is transfusion not suitable for AI HA 1st line

Answer 21

bcos it is primarily an AI condition, so giving blood replacement won’t solve the issue - the new cells will just get haemolysed

Question 22

29M bilateral lymphadenopathy.DDx?

Answer 22

acute EBV
follicular NHL
acute HIV
TB

Question 23

does MM ever have lymphadenopathy?

Answer 23

no

Question 24

who gets nodular sclerosing HL

Answer 24

young women

Question 25

what PC do nodular sclerosing HL have

Answer 25

widened mediastinal mass

Question 26

what is seen on biopsy of HL

Answer 26

reed steinberg cells

Question 27

how is HL staged

Answer 27

PET CT then Ann Arbour

Question 28

describe Ann Arbour stages

Answer 28

1 = single LN
2 = multiple LN one side of diaphragm
3 = LN above and below diaphragm
4 = mets beyond lymphatics (liver / BM)
A = no B Sx
B = B Sx

Question 29

Tx of Ann Arbour 1A HL

Answer 29

chemo
radio 2nd line

Question 30

which HL can you monitor watch and wait

Answer 30

CLL
SLL
follicular

Question 31

does chemo for HL affect fertility

Answer 31

modern - no
old chemo- yes, makes them infertile

Question 32

why is PET CT done after chemo in HL

Answer 32

to check for remission

Question 33

which has a higher WCC - leukaemia or lymphoma

Answer 33

leukaemia