MFD- antimicrobial products Flashcards
What are some examples of antimicrobials used in the UK /
Iodine
chlrohexidine
Triclosan
phenolic mouthrinses
What is the structure of CHX ?
bisbiguanide
What is the charge of CHX ?
cation
attracted to positive charge
What is the normal dosage of CHX ?
0,2%
twice daily
What are the problems with CHX ?
allergy
tooth staining
taste
What is triclosan ?
polychlorophenoxyphenol
How does CHX work ?
disrupts cell membrane phsopholipids
What is the substantivity of CHX ?
high
What is the substantivity of CHX ?
low
What are the properties of triclosan ?
lipid soluble - penetrates skin and mucosa
antiphlogistic
What type of antimicrobial is triclosan ?
broad spectrum
What are the actions of triclosan ?
target lipid ysnthesis - enoyl reductase
inhibits Pyruvate kinase and LDH in glycolysis
Inhbits H ATPase
What is the efficacy of triclosan that has been demonstrated ?
against gingivitis
What are the constituents of toothpastes ?
abrasives - silica fluoride surfactant CHX Triclosan Stannous fluoride Arginine
Why do we brush ?
spread fluoride
mechanical debridement
plaque remova;
prevent hallitosis
